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| 1 | Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study显示文摘 | William C Huang Andrew S Levey Angel M Serio Mark Snyder Andrew J Vickers Ganesh V Raj Peter T Scardino Paul Russo | 2006 | Lancet Oncology2006，，9： | 4 |
| 2 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 3 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 4 | Maintenance treatment with Pegylated liposomal doxorubicin versus observation following induction chemotherapy for metastatic breast cancer: GEICAM 2001-01 study显示文摘 | Emilio Alba Manuel Ruiz-Borrego Mireia Margelí álvaro Rodríguez-Lescure Pedro Sánchez-Rovira Amparo Ruiz Jose Ramón Mel-Lorenzo Manuel Ramos-Vázquez Nuria Ribelles Elisa Calvo Antonio Casado Antonia Márquez David Vicente José Angel García-Sáenz Miguel Mar | 2010 | Breast Cancer Research and Treatment2010，，1： | 2 |
| 5 | Health disparities among travelers visiting frends and relatives abroad显示文摘 | ANGELL S Y CETRON M S | 2005 | Ann Intern Med2005，142，1： | 1 |
| 6 | 显示文摘 | Sooklal K Cullum B S Angel S M | 1996 | J Phys Chem1996，100，11： | 1 |
| 7 | Uncovering the hidden geo- metry behind metabolic networks显示文摘 | Angeles S M Boguna M Sagues F | 2012 | Molecular BioSystems2012，8，3： | 1 |
| 8 | Consist gene silencing in transgenic plants expressing a replicating potato virus XRNA显示文摘 | Angel S M | 1997 | EMBOJ1997，16，： | 1 |
| 9 | Emission enhancement mechanisms in dual-pulse LIBS 显示文摘 | SCAFFIDI J M ANGEL S CREMERS D A | 2006 | Analytical Chemistry2006，78，1： | 1 |
| 10 | Genetics of resistance of rice cultivar ARC10550 to Bangladesh brown pianthopper teletype显示文摘 | Gurdev S Khush A N M Rezaul Karim E R Angeles | 1985 | Journal of Genetics (-)1985，，2： | 1 |
| 11 | Effect of pulse delay time on a pre-ablation dual-pulse LIBS plasma 显示文摘 | STRATIS D N ELAND K L ANGEL S M | 2001 | Applied Spectroscopy2001，55，10： | 1 |
| 12 | Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease显示文摘 | AARON S D ANGEL J B LUNAU M | 2001 | Am J Respir Crit Care Med2001，163，： | 1 |
| 13 | Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease显示文摘 | Aaron S D Angel J B Lunau M | 2001 | Am J Respir Crit Care Med2001，163，2： | 1 |
| 14 | Cytokinin oxidase regulates rice grain production显示文摘 | Ashikari M Sakakibara H Lin S Y Yamamoto T Takashi T Nishimura A Angeles E R Qian Q Kitano H Matsuoka M | 2005 | Science2005，309，： | 1 |
| 15 | Origin and basipetal transport of the IAA reponsible for rooting of carnation cuttings显示文摘 | Garrido G Ramón Guerrero J Angel Cano E Acosta M Sánchez-Bravo J | 2002 | Physiologia Plantarum2002，114，2： | 1 |
| 16 | Public: prefrences for ecosystem-enhallcing elements inagricultural landscapes in the Swiss lowlands显示文摘 | Home R Angel(me S Hunziker M ct al | 2014 | Jo riJal ofhtegrative Enviro*Jmetal Sciences2014，11，2： | 1 |
| 17 | Granulocyte inflammatory makers and airway infection during acute exacerbation of chronic obstructive pulmonary disease显示文摘 | AARON S D ANGEL J B LNNAU M | 2001 | Am J Respir Crit Care Med2001，163，2： | 1 |
| 18 | Validation of microcosms for examing the survival of Pseudomonas aureofaciens (lacZY) in soil 显示文摘 | Angel J S Levin M A Gagliardi J V | 1995 | Applied and Environmental Microbiology1995，61，8： | 1 |
| 19 | Tissue expanded radial forearmfree flap in neck bum contracture显示文摘 | Kenney JG DiMercurio S Angel M | | J Bum Care Rehabil !990 11(5)0，443，： | 1 |
| 20 | Identification of two surface proteins from C 6/36 cells that bind dengue type4 virus显示文摘 | Salas-Benito J S Angel R M D | 1997 | J Virol1997，71，10： | 1 |
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