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| 1 | Nosocomial colonization due to imipenem-resistant Pseudomonas aeruginosa epidemiologically linked to breast milk feeding in a neonatal intensive care unit显示文摘瞄准:我们描述殖民的一个年调查由 imipenem 抵抗,在巴勒莫的大学医院的一个新生的特别护理单位(NICU ) 生产 Pseudomonas aeruginosa 的 metallo-β-lactamase (MBL ) ,意大利。方法:未来的流行病学的调查在时期被进行 2003 1 月到 2004 1 月。直肠的拖把一个星期在整个他们的 NICU 停留从所有出生不满一月的婴儿被收集两次。由 P aeruginosa 的 imipenem 抵抗的紧张的 MBL 生产被 phenotypic 和分子的方法检测。搏动的地胶化电气泳动(PFGE ) 在所有上被执行 P 孤立 aeruginosa。在由 imipenem 抵抗的、 imipenem 易受影响的 P 的风险因素和 aeruginosa 孤立的殖民和另外的 multidrug 抵抗的克之间的协会否定(MDRGN ) 有机体为在承认并且在 NICU 停留期间在场的变量被分析。数据分析被艇长执行比例的危险回归模型。结果:210 个出生不满一月的婴儿中的 22 个被开拓殖民地于与 imipenem 抵抗,生产 MBL P aeruginosa 孤立, 14 由 imipenem 易受影响的 P aeruginosa 孤立。单个 pulsotype,命名 A,被 imipenem 抵抗的所有分享孤立。由 pulsotype A 的 P aeruginosa 的殖民断然被相关,母奶和 ampicillin-sulbactam 的管理喂,并且相反地与由公式的独占的喂相关。在艇长,比例的危险回归模型,超过 2500 g 的出生重量并且母奶喂是独立地由生产 MBL P aeruginosa.Conclusion 与殖民的增加的风险联系了:结果强烈支持在殖民之间的一个协会由一明确 imipenem 抵抗,喂的 MBL 生产 P aeruginosa 紧张和母奶。如此的研究可以加亮需要让策略的实现阻止表示母奶成为健康的车辆联系照顾的感染。 | Caterina MAMMINA Paola DI CARLO Domenico CIPOLLA Alessandra CASUCCIO Matilde TANTILLO MariaRosa Anna PLANO Angela MAZZOLA1, Giovanni CORSELLO | 2008 | Acta Pharmacologica Sinica2008，29，12： | 11 |
| 2 | Relationship of MTHFR gene polymorphisms with renal and cardiac disease显示文摘AIM: To investigate the effects of different methylenetetrahydrofolate reductase(MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are controversial.METHODS: We challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. The present article is a reappraisal of these concepts, investigating within a larger population, and including a subgroup of dialysis patients, if the two most common MTHFR polymorphisms, C677 T and A1298 C, as homozygous, heterozygous or with a compound heterozygous state, show different association with chronic renal failure requiring hemodialysis. MTHFR polymorphism could be a favorable evolutionary factor, i.e., a protective factor for many ominous conditions, like cancer and renal failure. A similar finding was reported in fatty liver disease in which it is suggested that MTHFR polymorphisms could have maintained and maintain their persistence by an heterozygosis advantage mechanism. We studied a total of 630 Italian Caucasian subject aged 54.60 ± 16.35 years, addressing to the increased hazard of hemodialysis, if any, according to the studied MTHFR genetic polymorphisms. RESULTS: A favorable association with normal renal function of MTHFR polymorphisms, and notably of MTHFR C677 T is present independently of the negative effects of left ventricular hypertrophy, increased IntraRenal arterial Resistance and hyperparathyroidism. CONCLUSION: MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism. | Francesca M Trovato Daniela Catalano Angela Ragusa G Fabio Martines Clara Pirri Maria Antonietta Buccheri Concetta Di Nora Guglielmo M Trovato | 2015 | World Journal of Nephrology2015，4，1： | 10 |
| 3 | Alterations of seminal and hormonal parameters:An extrahepatic manifestation of HCV infection?显示文摘瞄准:在精液的参数和繁殖神经质的浆液层次上评估 HCV 感染和相对抗病毒的处理的可能的影响。方法:有 HCV 相关的长期的肝炎和 16 个健康男志愿者的十个男病人被学习。在所有使精液的参数遭到(nemaspermic 集中,进步活动性,形态学) 并且神经质的层次被决定。精液的参数和抑制素 B,刺激滤泡的荷尔蒙, luteinizing,总数和免费睾丸激素,雌二醇,在病人的 prolactine 在六和 12 个月以后被测量抗病毒联合(interferon+ribavirin ) 治疗。结果:在治疗前的病人比控制象更低的抑制素 B 和免费睾丸激素层次一样显示出显著地更低的 nemaspermic 活动性和形态学。在情况中的抑制素 B 层次被改进在五个应答者的六和 12 瞬间术后疗法(161.9+/-52.8 pg/mL 对 101.7+/-47.0 pg/mL 和 143.4+/-46.1 pg/mL 对 95.4+/-55.6 pg/mL,分别地) 。病人的神经质的模式显著地没改变术后疗法,与有起始的减小和全面随后的增长(19.7+/-6.4 pg/mL 对 13.6+/-5.0 pg/mL 对 17.3+/-5.7 pg/mL ) 的雌二醇层次的例外。然而,在 1 年的应答者,免费睾丸激素(14.2+/-2.54 pg/mL 对 17.1+/-2.58 pg/mL ) 的重要增长发生了。nemaspermic 形态学的一个缺陷发生了,当另外的精液的参数没在抗病毒的治疗期间显著地变化时。结论:有 HCV 感染的病人比控制显示出更坏的精子的参数,建议精子发生上的病毒的可能的否定影响,与在抗病毒的治疗期间的进一步温和的缺陷。然而,治疗能改进精子的功能,由增加的抑制素 B 层次建议了并且在应答者改进了神经质的模式。进一步的研究被需要证实这些初步的吸引人的结果。 | Marilena Durazzo Alberto Premoli Cataldo Di Bisceglie Angela Bertagna Emanuela Fagà Giampaolo Biroli Chiara Manieri Simona Bo Gianfranco Pagano | 2006 | World Journal of Gastroenterology2006，12，19： | 9 |
| 4 | Cognitive impairment in multiple sclerosis: lessons from cerebrospinal fluid biomarkers显示文摘Cognitive impairment is a common clinical manifestation of multiple sclerosis,but its pathophysiology is not completely understood.White and grey matter injury together with synaptic dysfunction do play a role.The measurement of biomarkers in the cerebrospinal fluid and the study of their association with cognitive impairment may provide interesting in vivo evidence of the biological mechanisms underlying multiple sclerosis-related cognitive impairment.So far,only a few studies on this topic have been published,giving interesting results that deserve further investigation.Cerebrospinal fluid biomarkers of different pathophysiological mechanisms seem to reflect different neuropsychological patterns of cognitive deficits in multiple sclerosis.The aim of this review is to discuss the studies that have correlated cerebrospinal fluid markers of immune,glial and neuronal pathology with cognitive impairment in multiple sclerosis.Although preliminary,these findings suggest that cerebrospinal fluid biomarkers show some correlation with cognitive performance in multiple sclerosis,thus providing interesting insights into the mechanisms underlying the involvement of specific cognitive domains. | Lorenzo Gaetani Nicola Salvadori Elena Chipi Lucia Gentili Angela Borrelli Lucilla Parnetti Massimiliano Di Filippo | 2021 | Neural Regeneration Research2021，16，1： | 2 |
| 5 | Novel frontiers of agents for bowel cleansing for colonoscopy显示文摘The incidence of colorectal cancer(CRC)is characterized by rapid declines in the wake of widespread screening.Colonoscopy is the gold standard for CRC screening,but its accuracy is related to high quality of bowel preparation(BP).In this review,we aimed to summarized the current strategy to increase bowel cleansing before colonoscopy.Newly bowel cleansing agents were developed with the same efficacy of previous agent but requiring less amount of liquid to improve patients’acceptability.The role of the diet before colonoscopy was also changed,as well the contribution of educational intervention and the use of adjunctive drugs to improve patients’tolerance and/or quality of BP.The review also described BP in special situations,as lower gastrointestinal bleeding,elderly people,patients with chronic kidney disease,patients with inflammatory bowel disease,patients with congestive heart failure,inpatient,patient with previous bowel resection,pregnant/lactating patients.The review underlined the quality of BP should be described using a validate scale in colonoscopy report and it explored the available scales.Finally,the review explored the possible contribution of bowel cleansing in post-colonoscopy syndrome that can be related by a transient alteration of gut microbiota.Moreover,the study underlined several points needed to further investigations. | Milena Di Leo Andrea Iannone Monica Arena Giuseppe Losurdo Maria Angela Palamara Giuseppe Iabichino Pierluigi Consolo Maria Rendina Carmelo Luigiano Alfredo Di Leo | 2021 | World Journal of Gastroenterology2021，27，45： | 2 |
| 6 | Epidemiology and clinical features of Mycoplasma pneumoniae infection in children显示文摘 | Annacarla Defilippi Michela Silvestri Angela Tacchella Raffaella Giacchino Giovanni Melioli Eddi Di Marco Carmela Cirillo Pasquale Di Pietro Giovanni A. Rossi | 2008 | Respiratory Medicine2008，，12： | 2 |
| 7 | Rituximab-induced IgG hypogammaglobulinemia in children with nephrotic syndrome and normal pre-treatment IgG values显示文摘BACKGROUND In paediatric patients with complicated nephrotic syndrome(NS), rituximab(RTX) administration can induce persistent IgG hypogammaglobulinemia among subjects showing low basal immunoglobulin G(IgG) levels.AIM To evaluate the effect of RTX on IgG levels and infections in patients with complicated NS and normal basal IgG levels.METHODS We consecutively enrolled all patients with complicated NS and normal basal IgG levels undergoing the first RTX infusion from January 2008 to January 2016. Basal IgG levels were dosed after 6 wk of absent proteinuria and with a maximal interval of 3 mo before RTX infusion. The primary outcome was the onset of IgG hypogammaglobulinemia during the follow-up according to the IgG normal values for age [mean ± standard deviation(SD)].RESULTS We enrolled 20 patients with mean age at NS diagnosis of 4.2 ± 3.3 years. The mean age at the first RTX infusion was 10.9 ± 3.5 years. Eleven out of twenty patients(55%) developed IgG hypogammaglobulinemia. None of these patients showed severe or recurrent infections. Only one patient suffered from recurrent acute otitis media and underwent substitutive IgG infusion. Three patients undergoing only the two 'starting doses' experienced normalization of IgG levels. Using Kaplan-Meier analysis, the cumulative proportion of patients free of IgG hypogammaglobulinemia was 57.8% after the first RTX dose, 51.5% after the third dose, 44.1% after the fourth dose, and 35.5% after the fifth dose.CONCLUSION RTX can induce IgG hypogammaglobulinemia in patients with pre-RTX IgG normal values. None of the treated patients showed severe infections. | Pierluigi Marzuillo Stefano Guarino Tiziana Esposito Anna Di Sessa Sara Immacolata Orsini Daniela Capalbo Emanuele Miraglia del Giudice Angela La Manna | 2019 | World Journal of Clinical Cases2019，7，9： | 2 |
| 8 | Chitosan/whcy protein film as active coating to extend Ricotta cheese shelf-life 显示文摘 | Prospero Di Picrro Angela Sorrcntino | 2011 | Food Science and Technology2011，44，： | 1 |
| 9 | Effects of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as bolus in refractory congestive heart failure: Long-term effects显示文摘 | Giuseppe Licata Pietro Di Pasquale Gaspare Parrinello Antonietta Cardinale Angela Scandurra Giuseppe Follone Christiano Argano Antonino Tuttolomondo Salvatore Paterna | 2003 | American Heart Journal2003，，3： | 1 |
| 10 | Urban traffic control structure based on hybrid petri nets 显示文摘 | Angela Di Febbraro Davide Giglio Nicola Sacco | 2004 | IEEE Transactions on Intelligent Transportation Systems2004，5，4： | 1 |
| 11 | Behavior of optical thin-film materials and coatings under proton irradiation and gamma irradiation显示文摘 | Angela Piegari Haria Di Sarcina Maria Luisa Grilli | 2014 | Applied Optics(SI559-128X)2014，53，4： | 1 |
| 12 | On modeling urban transportation networks via hybrid Petri nets显示文摘 | Angela Di Febbraro Nicola Sacco | 2004 | Control Engineering Practice2004，12，10： | 1 |
| 13 | Fenton's pre-treatment of mature landfill leachate显示文摘 | Antonio Lopez Michele Pagano Angela Volpe Appio Claudio Di Pinto | 2003 | Chemosphere2003，54，： | 1 |
| 14 | Cloning of the bovine prion-like Shadoo (SPRN) gene by comparative analysis of the predicted genomic locus显示文摘 | Cristina Uboldi Marianna Paulis Elena Guidi Anna Bertoni Giulia Pia Di Meo Angela Perucatti Leopoldo Iannuzzi Elena Raimondi Ronald M. Brunner André Eggen Luca Ferretti | 2006 | Mammalian Genome2006，，11： | 1 |
| 15 | Adaptations to new environments in humans: the role of subtle allele frequency shifts显示文摘 | Angela M. Hancock Gorka Alkorta-Aranburu David B. Witonsky Anna Di Rienzo | 2010 | Philosophical Transactions of the Royal Society B2010，，1552： | 1 |
| 16 | Treatment of human papillomavirus infection with interferon alpha and ribavirin in a patient with acquired aplastic anemia显示文摘 | Clara Mosa Antonino Trizzino Angela Trizzino Floriana Di Marco Paolo D’Angelo Piero Farruggia | 2014 | International Journal of Infectious Diseases2014，，： | 1 |
| 17 | Detection of pathogenic Vibrio parahaemolyticus in southern Italian shell- fish显示文摘 | Angela Di Pinto Giuseppina Ciccarese Rita De Corato | 2007 | Food control2007，19，11： | 1 |
| 18 | Evaluation of Mycobacterium tuberculosis cross-resistance to isoni- azid,rifampicin and levofloxacin with their respective structural analogs显示文摘 | Belen Rocio I Angela Beatriz Di Giulio | 2014 | Journal of Antibiotics2014，67，11： | 1 |
| 19 | Detection of pathogenic Vibrio parahaemolyticus isouthern Italian shellfish显示文摘 | Angela Di Pinto Giuseppina Ciccarese Rita De Corato | 2008 | Food Control2008，，19： | 1 |
| 20 | Chitosan/whey protein film as active coating to extend Ricotta cheese shelf- life 显示文摘 | Prospero Di Pierro Angela Sorrentino Loredana Mariniello | 2011 | LWT- Food Science and Technology2011，44，10： | 1 |
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