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| 1 | Apoptosis is not an invariable component of in vitro models of cortical cerebral ischaemia显示文摘Characterising the mechanisms of cell death following focal cerebral ischaemia has been hampered by a lack of an in vitro assay emulating both the apoptotic and necrotic features observed in vivo. The present study systematically characterised oxygen-glucose-deprivation (OGD) in primary rat cortical neurones to establish a reproducible model with components of both cell-death endpoints. OGD induced a time-dependent reduction in cell viability, with 80% cell death occurring 24 h after 3 h exposure to 0% O2 and 0.5 mM glucose. Indicative of a necrotic component to OGDinduced cell death, N-methyl-D-aspartate (NMDA) receptor inhibition with MK-801 attenuated neuronal loss by 60%.The lack of protection by the caspase inhibitors DEVD-CHO and z-VAD-fmk suggested that under these conditions neurones did not die by an apoptotic mechanism. Moderating the severity of the insult by decreasing OGD exposure to 60 min did not reduce the amount of necrosis, but did induce a small degree of apoptosis (a slight reduction in cell death was observed in the presence of 10 μtM DEVD-CHO). In separate experiments purported to enhance the apoptotic component, cells were gradually deprived of O2, exposed to 4% O2 (as opposed to 0%) during the OGD period, or maintained in serum-containing media throughout. While NMDA receptor antagonism significantly reduced cortical cell death under all conditions, a caspase-inhibitor sensitive component of cell death was not uncovered. These studies suggest that OGD of cultured cortical cells models the excitotoxic, but not the apoptotic component of cell death observed in vivo. | Paul Alexander JONES Gillian Ruth MAY Joyce Ann MCLUCKIE Akinori IWASHITA John SHARKEY | 2004 | Cell Research2004，14，3： | 3 |
| 2 | Gradients in predation risk in a tropical river system显示文摘 | Amy E. DEACON Faith A. M. JONES Anne E. MAGURRAN | 2018 | Current Zoology2018，64，2： | 3 |
| 3 | Growth Differentiation Factor-15 as Biomarker in Uterine Sarcomas显示文摘 | Jone Trovik Helga Birgitte Salvesen Tine Cuppens Frederic Amant Anne Cathrine Staff | 2014 | International Journal of Gynecological Cancer2014，，2： | 2 |
| 4 | Molecular Genetic Evidence for a Common Clonal Origin of Urinary Bladder Small Cell Carcinoma and Coexisting Urothelial Carcinoma显示文摘 | Liang Cheng Timothy D. Jones Ryan P. McCarthy John N. Eble Mingsheng Wang Gregory T. MacLennan Antonio Lopez-Beltran Ximing J. Yang Michael O. Koch Shaobo Zhang Chong-Xian Pan Lee Ann Baldridge | 2005 | The American Journal of Pathology2005，，5： | 2 |
| 5 | Citrulline as a Biomarker in the Non-human Primate Total- and Partial-body Irradiation Models: Correlation of Circulating Citrulline to Acute and Prolonged Gastrointestinal Injury显示文摘 | Jace W. Jones Alexander Bennett Claire L. Carter Gregory Tudor Kim G. Hankey Ann M. Farese Catherine Booth Thomas J. MacVittie Maureen A. Kane | 2015 | Health Physics2015，，5： | 1 |
| 6 | Diagnosis and Management of Childhood Obstructive Sleep Apnea Syndrome显示文摘 | Carole L. Marcus Lee J. Brooks Sally Davidson Ward Kari A. Draper David Gozal Ann C. Halbower Jacqueline Jones Christopher Lehmann Michael S. Schechter Stephen Sheldon Richard N. Shiffman Karen Spruyt | 2012 | PEDIATRICS2012，，3： | 1 |
| 7 | Alternative Approaches to the Employees Pay Off ? 显示文摘 | TSUI Anne S PEARCE Jone L | 1997 | Academy of Management Journal1997，，5： | 1 |
| 8 | Longitudinal relations between obesity and hypertension following pediatric renal transplantation显示文摘 | Michelle R. Denburg Madhura Pradhan Justine Shults Abigail Jones Jo Ann Palmer H. Jorge Baluarte Mary B. Leonard | 2010 | Pediatric Nephrology2010，，10： | 1 |
| 9 | Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning显示文摘 | Samuel Davis Thomas H Aldrich Pamela F Jones Ann Acheson Debra L Compton Vivek Jain Terence E Ryan Joanne Bruno Czeslaw Radziejewski Peter C Maisonpierre George D Yancopoulos | 1996 | Cell1996，，7： | 1 |
| 10 | Developing a problem - based learning (PBL) curriculum for professionalism and scientific integrity training for biomedical graduate students 显示文摘 | Nancy L Jones Ann M Peiffer Ann Lambros | 2010 | Med Ethics2010，36，： | 1 |
| 11 | Gender differences in students' experiences interests and attitudes toward science and scientists显示文摘 | JONES M G ANN H MELISSA J R | 2000 | Science Education2000，84，： | 1 |
| 12 | Impact of Anal Incontinence on Psychosocial Function and Health-Related Quality of Life显示文摘 | Michael D. Crowell V. Ann Schettler Brian E. Lacy Tisha N. Lunsford Lucinda A. Harris John K. DiBaise Michael P. Jones | 2007 | Digestive Diseases and Sciences2007，，： | 1 |
| 13 | Redefining Neighborhoods Using Common Destinations: Social Characteristics of Activity Spaces and Home Census Tracts Compared显示文摘 | Malia Jones Anne R. Pebley | 2014 | Demography2014，，3： | 1 |
| 14 | Learning technologies:Affective and social issues in computer-supported collaborative learning显示文摘 | Kim Issro | 2005 | Computers & Education2005，44，： | 1 |
| 15 | Microtubule Reduction in Alzheimer’s Disease and Aging Is Independent of τ Filament Formation显示文摘 | Adam D. Cash Gjumrakch Aliev Sandra L. Siedlak Akihiko Nunomura Hisashi Fujioka Xiongwei Zhu Arun K. Raina Harry V. Vinters Massimo Tabaton Anne B. Johnson Manuel Paula-Barbosa Jesus Avíla Paul K. Jones Rudy J. Castellani Mark A. Smith George Perry | 2003 | The American Journal of Pathology2003，，5： | 1 |
| 16 | Reduced Longitudinal Excursion of the Median Nerve in Carpal Tunnel Syndrome显示文摘 | Alan D. Hough Ann P. Moore Mark P. Jones | 2007 | Archives of Physical Medicine and Rehabilitation2007，，： | 1 |
| 17 | Preparation, Characterization, and Catalysis of a Modi- fied ZSM-5 Zeolite显示文摘 | Gaffney Anne M Jones C.A Sofranko John A Tsiao C Dy- bowski C | | 0，，： | 1 |
| 18 | Gastric Emptying, Incretin Hormone Secretion, and Postprandial Glycemia in Cystic Fibrosis—Effects of Pancreatic Enzyme Supplementation显示文摘 | Paul Kuo Julie E. Stevens Antonietta Russo Anne Maddox Judith M. Wishart Karen L. Jones Hugh Greville David Hetzel Ian Chapman Michael Horowitz Christopher K. Rayner | 2011 | The Journal of Clinical Endocrinology & Metabolism2011，，5： | 1 |
| 19 | Developing a prob- lem-based learning(PBL)curriculum for professionalism and scientific integrity training for biomedical graduate students 显示文摘 | Mancy L Jones Ann M Peiffer Ann Lambros | 2010 | Med Ethics2010，36，： | 1 |
| 20 | Prevalence and Socioeconomic Impact of Upper Gastrointestinal Disorders in the United States: Results of the US Upper Gastrointestinal Study显示文摘 | Michael Camilleri Dominique Dubois Bernard Coulie Michael Jones Peter J. Kahrilas Anne M. Rentz Amnon Sonnenberg Vincenzo Stanghellini Walter F. Stewart Jan Tack Nicholas J. Talley William Whitehead Dennis A. Revicki | 2005 | Clinical Gastroenterology and Hepatology2005，，6： | 1 |
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