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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Impact of enclosure management on soil properties and microbial biomass in a restored semi-arid rangeland, Kenya显示文摘Rangeland degradation is a serious problem throughout sub-Saharan Africa and its restoration is a challenge for the management of arid and semi-arid areas. In Lake Baringo Basin of Kenya, communities and individual farmers are restoring indigenous vegetation inside enclosures in an effort to combat severe land degradation and address their livelihood problems. This study evaluated the impact of enclosure management on soil properties and microbial biomass, being key indicators of soil ecosystem health. Six reseeded communal enclosures using soil embankments as water-harvesting structures and strictly regulated access were selected, varying in age from 13 to 23 years. In six private enclosures, ranging from 3 to 17 years in age, individual farmers emulated the communal enclosure strategy and restored areas for their exclusive use. Significant decreases in bulk density, and increases in the soil organic carbon, total nitrogen and microbial biomass contents and stocks were found in the enclosures as compared with the degraded open rangeland. In the private enclosures, the impact of rehabilitation on the soil quality was variable, and soil quality was in general lower than that obtained under communal management. The significant increase of absolute stocks of carbon, nitrogen and microbial biomass compared to the degraded open rangeland indicates the potential for the restoration of soil quality through range rehabilitation. Over-sowing with indigenous legume fodder species could improve total nitrogen content in the soil and nutritional value of the pastures as well. | Stephen M MUREITHI Ann VERDOODT Charles KK GACHENE Jesse T NJOKA Vivian O WASONGA Stefaan De NEVE Elizabeth MEYERHOFF Eric Van RANST | 2014 | Journal of Arid Land2014，6，5： | 3 |
| 3 | Cholangiocarcinoma, gone without the Wnt?显示文摘Cholangiocarcinoma(CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts that is classified according to its anatomical localization as intrahepatic, perihilar or distal. Overall, CCA has a dismal prognosis due to typical presentation at an advanced irresectable stage, lack of effective non-surgical treatments, and a high rate of disease recurrence. CCA frequently arises on a background of chronic liver inflammation and cholestasis. Chronic inflammation is accompanied by enhanced cell turnover with generation of additional inflammatory stimuli, and a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accumulation of mutations, transformation and expansion of mutated cells. A recent study by Boulter et al implicates the Wnt signaling cascade in cholangiocarcinogenesis. Wnt ligands Wnt7 B and Wnt10 A were found to be highly overexpressed in human CCA tissue. Wnt7 B protein was present throughout the tumor stroma, and often co-localized with a subset of CD68+ macrophages. To address in a direct manner whether Wnt signaling is engaged in development of CCA, Boulter et al explored the Wnt signaling pathway in an experimental model that recapitulates the multi-stage progression of human CCA.Wnt ligands found to be elevated in human CCA were also upregulated during the course of CCA development following thioacetamide treatment. Wnt10 a increased during the(pre-cancerous) regenerative phase, while Wnt7 b induction paralleled tumor growth. Along with upregulation of target genes, the findings demonstrate that the canonical Wnt pathway is progressively activated during cholangio-carcinogenesis. Macrophage depletion,eliminating a major source of Wnt7 b, prevented activation of the canonical Wnt cascade, and resulted in reduced number and volume of tumors in this model. Moreover,specific inhibitors of the canonical Wnt pathway(ICG-001 and C-59) caused reduction of tumor area and number,in xenograft and thioacetamide models of CCA. The aggregated findings show that experimental, and presumably human CCA, is a Wnt-driven tumor. Modulation of Wnt signaling, alone or in combination with surgicalor chemotherapy approaches, holds promise in the management of this fatal malignancy. | Anne T R Noll Thorsten Cramer Steven W M Olde Damink Frank G Schaap | 2016 | World Journal of Hepatology2016，8，26： | 3 |
| 4 | Outpatient laparoscopic extraperitoneal aortic nodal dissection for locally advanced cervical carcinom a显示文摘 | LOW E M P TILLM ANNS T | 2008 | Gynecol Oncol2008，111，2： | 1 |
| 5 | Reaction time of facial affect recognition in Asperger's disorder for cartoon and real,static and moving faces显示文摘 | Motohide M Anne B Masatsugu T | | 0，，： | 1 |
| 6 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 7 | Safety,feasibility,and costs of outpatient laparoscopic extraperitoneal aortic nodal dissection for locally advanced cervical carcinom a显示文摘 | TILLM ANNS T LOW E M P | 2007 | Gynecol Oncol2007，106，2： | 1 |
| 8 | A landscape ecology assessment of the Tensas River Basin 显示文摘 | Daniel T H Curtis M E Anne C N | 2000 | Environmental Monitoring and Assessment2000，64，1： | 1 |
| 9 | ACC/AHA Guidelines 2005 Update for the Diagnosis and Management of Chronic Heart Faihtre in the Adult 显示文摘 | Sharon Ann Hunt William T Abraham Donna M Maneini | 2005 | Circulation2005，112，： | 1 |
| 10 | Induced angiogenesis under cerebral ischemia by cyclooxygenase 2 and hypoxia-inducible factor naked DNA in a rat indirect-bypass model显示文摘 | Ann M Abe T Matsuda T | 2006 | Neurosci lett2006，409，2： | 1 |
| 11 | Diet composition of three anurans from the Playa Wetlands of Northwest Texas显示文摘 | Ann M Anderson David A Haukos James T Anderson | 1999 | Copeia1999，，2： | 1 |
| 12 | Manual versus target-con-trolled in fusion remifentanil administration in Spontaneously breathing Patients显示文摘 | Annelies T M LucL H Martine MD eta1 | 2009 | Anesth Analg2009，108，3： | 1 |
| 13 | Executive Compensation, Management Turnover and Firm Performance : An Empirical Investigation 显示文摘 | Coughlan Anne T Schmidt Ronald M | 1985 | Journal of Accounting and Economics1985，，7： | 1 |
| 14 | A highly unsaturated fat acid predicts carbon transfer between primary producers and consumers显示文摘 | Muller Navarra D C Brett M T Anne M | 2000 | Nature2000，403，6： | 1 |
| 15 | Comparison of amplified ribosomal DNA restriction analysis,peptidoglycan hydrolase and biochemical profiles for rapid dairy propionibacteria species identification显示文摘 | Julien D Anne T Madec M N | 2006 | Research in Microbiology2006，157，： | 1 |
| 16 | Electrochemical treatment and HPLC analysis of wastewater containing acid dyes显示文摘 | Suzanne M Ann T L | 1994 | Textile Chemists and Colorists1994，26，4： | 1 |
| 17 | Changes in male reproductive health and effects of endocrine disruptor in Scandinavian countries 显示文摘 | Jorma T Anne M H Markku A | 2002 | Cad Satide P6blica Riode Janeiro2002，18，2： | 1 |
| 18 | Thyroid dys- function and autoantibodies during pregnancy as predic- tive factors of pregnancy complications and maternal mor- bidity in later Life显示文摘 | M~innist6 T V/i/ir/ism/iki M Anneli P | 2010 | J Clinendocrinol Metab2010，95，3： | 1 |
| 19 | Evidence of Atmospheric Paleocirculation over the Gulf of Guinea since the Last Glacial Maximum显示文摘 | JEAN P T | 1994 | Qua ternary Research1994，41，： | 1 |
| 20 | Age-dependent effects of trihexyphenidyl in extrapyramidal cerebral palsy显示文摘 | Alexander H Hoon Patricia O Freese Elsie M Reinhardt Mary Ann Wilson William T Lawrie Susan E Harryman Frank S Pidcock Michael V Johnston | 2001 | Pediatric Neurology2001，，1： | 1 |
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