|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | QUADAS评价:一种用于诊断性研究的质量评价工具(修订版)显示文摘背景 QUADAS是一种新近发展起来的诊断性研究的质量评价工具。虽然已有系统评价采用了QUADAS,但尚未得以正式确证。本研究的目的是评价QUADAS的有效性和实用性。方法3位评价者采用QUADAS独立评价30项研究的质量。比较每位评价者的评分与最终结论之间的意见一致度。这主要是通过比较所有QUADAS条目的总分和每个单项的得分来实现的。20位曾在其系统评价中使用过QUADAS的评价者就其使用经验完成一份简短的问卷。结果就所有条目而言,每位评价者的评分与最终结论之间的意见一致度分别达到了91%、90%和85%。就单项QUADAS条目而言,一致度在50%至100%之间,中位值是90%。与难以解释的试验结果和退出病例相关的条目,评分结果差异最大。有关QUADAS内容的反馈意见普遍较好,仅少数评价者提出了有关QUADAS涵盖面、使用便利性、评分说明的清晰度及有效性方面的问题。结论QUADAS内容本身无需作大的修改。评价过程的主要困难出现在难以解释的试验结果和退出病例这2个条目的评分上。对这些条目的评分指南提出了修改意见。评价者必需根据其系统评价制定相应的评分指南,并确保所有评价者都清楚如何评分。评价者还应考虑是否所有的QUADAS条目都与其系统评价相关,以及其他质量条目是否应作为其系统评价的评价部分。 | Penny F Whiting Marie E Weswood Anne WS Rutjes Johannes B Reitsma Patrick NM Bossuyt Jos Kleijnen 马章淳 钱楠 | 2007 | 中国循证医学杂志2007，7，7： | 64 |
| 2 | 影响卒中死亡率下降的因素美国心脏协会/美国卒中协会的科学声明显示文摘背景和目的 美国的卒中死亡率自20世纪初以来一直呈下降趋势,尽管这种“下降”很受欢迎,但其原因尚不完全清楚.由于近年来卒中死亡率呈现出更为显著的加速下降趋势,卒中已从美国的第3位死亡原因下降至第4位.这促使人们对影响卒中发病风险和死亡率变化的相关因素进行详细评估.这份声明对有关卒中死亡率下降趋势的促进因素的研究证据进行回顾,并讨论了将来如何利用这些因素在卒中这一重大公共卫生问题的干预研究中发挥作用.方法 写作组成员由委员会主席和副主席根据其以前在相关领域的研究成果提名,并通过美国心脏协会(American Heart Association,AHA)卒中委员会的科学声明监督委员会和美国心脏协会手稿监督委员会批准.作者利用系统文献综述,参考公开发表的临床和流行病学研究、发病率和死亡率报告、临床与公共卫生指南、权威声明、个人文件以及专家意见,对相关证据进行总结并指出与当前知识水平的差距.所有写作组成员均有机会评论这份声明并批准其最终版本.这份声明经过AHA内部的广泛同行评议以及卒中委员会领导阶层和科学声明监督委员会的审查,然后获得AHA科学顾问与协调委员会的批准.结果 过去数十年间,在不同性别、所有种族/民族以及各个年龄组人群中都观察到卒中死亡率的下降,这体现出人群健康的重大进展.除了卒中对于总体寿命损失的影响减少外,在65岁以下人群中观察到的卒中死亡率显著下降体现了其所致潜在寿命损失年的减少.卒中死亡率的下降要归功于卒中发病率和病死率的降低.这些卒中转归的显著改善与心血管危险因素的控制和干预相一致.虽然很难计算出具体的归因危险度估计值,但始于20世纪70年代的血压控制措施似乎已对卒中死亡率的加速下降产生了最实质性的影响.尽管实施较晚,但糖尿病和血脂异常控制以及戒烟计划,特别是联合降压治疗,似乎同样促进了卒中死亡率的下降.远程医疗和卒中医疗体系也似乎具有强烈的潜在作用,但尚需足够长的时间来证明其对卒中死亡率下降的影响.其他因素也可能产生影响,但需要更多的研究来确定它们的作用.结论 卒中死亡率的下降是真实存在的,代表着公共卫生以及临床医学的巨大成功.卒中从第3位死亡原因下降至第4位是死亡率真实下降的结果,而并非由于慢性肺病死亡率上升所致,后者是目前在美国是第3位的死亡原因.有强烈的证据表明,卒中死亡率的下降可归功于以科学发现为基础、旨在降低卒中风险而执行的联合干预措施和项目,其中最有可能的是对高血压控制的改善.因此,对正在开展的干预项目进行的研究及其成果的应用已改善了人群健康.对一些积极的循证公共卫生项目以及临床干预措施的持续应用预期会进一步降低卒中死亡率. | Daniel T.Lackland Edward J.Roccella Anne F.Deutsch Myriam Fornage Mary G.George George Howard Brett M.Kissela Steven J.Kittner Judith H.Lichtman Lynda D. Lisabeth Lee H. Schwamm Eric E. Smith 高一鹭 陈政弘 王文志 | 2014 | 国际脑血管病杂志2014，22，5： | 41 |
| 3 | Abstract from: Pharmacologic treatment of hypertension in adults aged 60 years or older to higher versus lower blood pressure targets: A clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians显示文摘Description: The American College of Physicians (ACP) and the American Academy of Family Physicians (AAFP) jointly developed this guideline to present the evidence and provide clinical recommendations based on the benefits and harms of higher versus lower blood pressure targets for the treatment of hypertension in adults aged 60 years or older. | Amir Qaseem Timothy J. Wilt Robert Rich Linda L. Humphrey Jennifer Frost Mary Ann Forciea | 2017 | Chinese Nursing Research2017，4，4： | 43 |
| 4 | 农业耕作活动对西藏越冬黑颈鹤食性及食物可获得性的影响显示文摘于 1996年 1月对在西藏中南部越冬黑颈鹤的食性和谷物性食物的可获得性进行了研究。青稞 (Hordeumvulgare)、春小麦 (Triticumspp .)、冬小麦 (Triticumspp .)是该地区的 3种主要作物。对黑颈鹤粪便的分析表明 ,越冬黑颈鹤取食大量的农作物 ,尤其是小麦散落谷粒 ,而冬小麦苗仅占鹤类食物组成的很小一部分。秋收后的翻耕、放牧等农业活动影响地面上作物残物 (种子、叶、秆或根 )及谷粒残物 (裸粒、穗、稃 )的数量 ,农地翻耕掩埋了大部分的作物残物。未翻耕青稞地与小麦地上的作物残物覆盖比值相似。谷粒残物的密度在未翻耕的小麦地上最大。为了最大限度地增加黑颈鹤的冬季食物资源 ,减少人为活动对黑颈鹤的干扰 ,我们建议 :在秋收后不要翻耕河流两侧的青稞地和小麦地 ;在冬小麦种植地区 ,冬小麦应仅仅种植在主要公路两侧。 | Mary Anne Bishop 李凤山 | 2002 | 生物多样性2002，10，4： | 36 |
| 5 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 6 | 基于InVEST模型的1980–2100年长江中下游地区动植物生境质量时空变化研究显示文摘20世纪80年代以来,人类活动加速了长江流域的土地利用变化,这对当地动植物的生境质量造成了影响,在中国生态文明建设和长江经济带发展战略不断推进的大背景下,对长江中下游地区的生境质量变化开展长时间多时段的研究具有重要的现实意义。本研究以长江中下游地区7省的土地利用覆盖数据(1980–2018年)与未来土地利用模型模拟出未来四种情景(A1B,A2,B1,B2)下的土地利用覆盖数据(2050年,2100年)为基础,借助环境服务与权衡综合评估(In VEST)模型评估了长江中下游地区的生境质量时空变化。结果表明:(1)2000–2015年,研究区的坡度(R=0.502,P <0.01)和海拔(R=0.003,P <0.05)、人口密度(R=0.299,P <0.01)、NDVI(R=0.366,P <0.01)与生境质量显著相关;(2)从1980年到2018年,研究区总面积61.93%的土地生境质量下降,38.07%的土地生境质量上升;在A2情景(人口密度大,环境技术投入少,传统能源成本高)和B2情景(中等人口密度,中等绿色技术,区域政府间缺乏合作)下,研究区的生境质量将下降;(3)长江下游的生境质量恶化程度高于中游,研究区北部的生境质量恶化程度低于南部。整体上,积极的环境保护政策是有效的,但并未根本上遏制生境质量的整体退化趋势。区域发展应加大环境保护力度,控制人口增长,鼓励绿色技术创新,在处理生态问题时,要注重省际合作。本研究可为区域野生动植物保护规划和国际上的类似流域研究提供科学参考。 | 李晴 周勇 Mary Ann CUNNINGHAM 徐涛 | 2021 | Journal of Resources and Ecology2021，12，1： | 17 |
| 7 | 大熊猫电刺激采精及精液冷冻保存研究显示文摘对卧龙自然保护区大熊猫研究中心的 9只 5 5~ 16 5岁的雄性大熊猫进行了 17次电刺激采精 .其中 3只是能进行自然交配并繁殖了后代的种公兽 .比较研究了精液离心、不同稀释液和冷冻方法对大熊猫精液超低温冷冻保存后的活力、运动状态、精子和顶体形态的影响 .细管冷冻是 1种较好的超低温冷冻精液的方法 . | 黄炎 李德生 张和民 杜军 张贵权 王鹏彦 Jogayle Howard Rrbacca Spindler Barbara Durrant Mary Ann Olson | 2000 | 四川师范学院学报(自然科学版)2000，21，3： | 16 |
| 8 | 夏季电力短缺的解决方案——电力需求响应及其在空调制冷系统中的应用显示文摘电力需求响应是解决电力供求矛盾的有效工具,是保证电网安全经济运行的可靠资源。本文介绍电力需求响应及需求侧管理的基本概念及其区别,系统地阐明电力需求响应的分类及实施项目,列举电力需求响应措施在空调制冷系统中的应用,并通过介绍国外的成功实例指出电力需求响应的有效性,最后,为中国电力需求响应的开展提出建议。 | 韩珺巧 Mary Ann Piette | 2008 | 制冷空调与电力机械2008，29，1： | 13 |
| 9 | Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials显示文摘Millions of people worldwide suffer from a toothache due to tooth cavity,and often permanent tooth loss.Dental caries,also known as tooth decay,is a biofilm-dependent infectious disease that damages teeth by minerals loss and presents a high incidence of clinical restorative polymeric fillings(tooth colored fillings).Until now,restorative polymeric fillings present no bioactivity.The complexity of oral biofilms contributes to the difficulty in developing effective novel dental materials.Nanotechnology has been explored in the development of bioactive dental materials to reduce or modulate the activities of caries-related bacteria.Nano-structured platforms based on calcium phosphate and metallic particles have advanced to impart an anti-caries potential to restorative materials.The bioactivity of these platforms induces prevention of mineral loss of the hard tooth structure and antibacterial activities against caries-related pathogens.It has been suggested that this bioactivity could minimize the incidence of caries around restorations(CARS)and increase the longevity of such filling materials.The last few years witnessed growing numbers of studies on the preparation evaluations of these novel materials.Herein,the caries disease process and the role of pathogenic caries-related biofilm,the increasing incidence of CARS,and the recent efforts employed for incorporation of bioactive nanoparticles in restorative polymer materials as useful strategies for prevention and management of caries-related-bacteria are discussed.We highlight the status of the most advanced and widely explored interaction of nanoparticle-based platforms and calcium phosphate compounds with an eye toward translating the potential of these approaches to the dental clinical reality. | Abdulrahman A.Balhaddad Anmar A.Kansara Denise Hidan Michael D.Weir Hockin H.K.Xu Mary Anne S.Melo | 2019 | Bioactive Materials2019，4，1： | 9 |
| 10 | 利用Minirhizotron技术监测火炬松新根生长动态显示文摘利用Minirhizotron技术 ,研究了位于美国路易斯安那州的 19年生的火炬松新根生长动态。结果表明 ,火炬松新根的根量密度随时间呈增长趋势 ,在生长季末的 1、2月份达到最大。经过林地土壤干旱处理 (通过建立穿透雨隔离系统 ,阻止雨水到达地面 )的树木的根量密度自 9.3cm处 ,随土壤深度增加呈下降趋势 ,未经干旱处理的树木在离土表 80 10 0cm深处仍有较高的根量密度 ,达 3.4 8 5 .12条·m- 1,是经干旱处理树木对应土壤层次中根量密度的 10多倍。火炬松从 3月份开始发生新根 ,随后迅速增加 ,至 6月份发生最多 ,然后缓慢减少 ,5 7月的新根发生数占总量的 4 1.8% ,大部分新根发生在离土表 30cm以内的土壤中。 11个月的干旱处理显著地降低火炬松的根量密度 (1 1条·m- 1,未经干旱处理的为 3 2 7条·m- 1)和新根发生数 (5 7条·株- 1,未经干旱处理的为 15 6条·株 - 1) ,干旱处理还可导致新根推迟 1 0 1.5个月发生。 | 周本智 Mary Anne Sword JimL Chambers CDan Andries | 2002 | 林业科学研究2002，15，3： | 9 |
| 11 | 医疗卫生绩效薪酬支付的国际经验及对中国的启示显示文摘为提高医疗质量,过去几十年来世界各国在医疗卫生系统设计并推行了'绩效薪酬支付'项目。这些项目针对不同的对象以及单位和部门进行激励。近年,绩效薪酬被逐渐引入我国医疗卫生系统。本文回顾了国际上主要国家(美国、法国和英国等)在医疗卫生体系内推行的绩效薪酬项目,梳理了各国在项目设计时的共性经验,总结了项目设计时需要考虑的关键要素,包括项目的激励对象、绩效指标、激励方式、绩效基准等,并分析这些要素的优缺点及实施中可能出现的问题,旨在为我国的医疗卫生系统绩效薪酬改革提供参考。 | 蒋舒 阎川 Anne Girault Marie Ferrua Aude Fourcade Philippe Loirat Etienne Minvielle | 2015 | 中国卫生政策研究2015，8，2： | 9 |
| 12 | ≥60岁高血压病人控制血压在较高或较低水平的药物治疗--美国医师协会和美国家庭医师学会临床实践指南显示文摘目的:针对≥60岁的高血压病人治疗中较高和较低降压目标的利弊,美国医师协会(ACP)和美国家庭医师学会(AAFP)共同制订了这一指南,为临床治疗提供证据及治疗建议。方法:本指南依据于已发表的主要疗效指标的随机对照试验以及针对危害的观察性研究的系统性评价。资料来源于EMBASE、系统性综述Cochrane数据库、MEDLINE和Clinical Trials.gov,搜索时间为从数据库建立开始至2015年1月,其中MEDLINE数据更新到2016年9月。评估指标包括全因死亡率、与卒中相关的发病率和死亡率、主要心脏事件(包括致死和非致死性心肌梗死和心源性猝死)和危害。本指南采用GRADE法(Grading of Recommendations,Assessment,Development,and Evaluation)对证据和建议进行分级。目标使用者和病人人群:本指南的目标使用者为所有临床医师,目标病人人群包括所有年龄≥60岁的高血压病人。建议1:对≥60岁、收缩压持续≥150mmHg(1mmHg=0.133kPa)的病人治疗时,ACP和AAFP建议临床医师应启动降压治疗以控制收缩压<150mmHg,从而减少死亡、脑卒中和心脏事件的风险(等级:强烈推荐,高质量证据)。对≥60岁高血压病人进行治疗时,建议临床医生定期与病人具体讨论降压目标的利弊,根据讨论情况选择治疗目标。建议2:对≥60岁的有脑卒中或短暂性脑缺血发作病史的病人,ACP和AAFP建议临床医生考虑启动或者加强药物治疗,以控制收缩压<140mmHg,降低脑卒中复发的风险(等级:弱推荐,中等质量证据)。对≥60岁高血压病人进行治疗时,建议临床医生定期与病人具体讨论降压目标的利弊,根据讨论情况选择治疗目标。建议3:对一部分≥60岁有高度心血管风险的病人,ACP和AAFP建议临床医生根据个体评估情况考虑启动或者强化降压药物治疗,控制收缩压到140mmHg以下,从而减少脑卒中或心脏事件发生的风险(等级:弱推荐,低质量证据)。对≥60岁高血压病人进行治疗时,建议临床医生定期与病人具体讨论降压目标的利弊,根据讨论情况选择治疗目标。 | Amir Qaseem Timothy J.Wilt Robert Rich Linda L.Humphrey Jennifer Frost Mary Ann Forciea | 2017 | 护理研究(下旬版)2017，31，8： | 8 |
| 13 | 西藏黑颈鹤和斑头雁碰撞输电线的研究(英文)显示文摘我们在西藏自治区雅鲁藏布江河谷进行了为期两个冬季的黑颈鹤(Grus nigricollis)和斑头雁(Anserindicus)碰撞输电线路的调查。每个冬季,在一条 35 kV 的输电线路上设置 3 条样线,观察受伤和死亡的个体。受伤的个体在发现 5 天以后就不见了,而多数死亡个体的残骸发现时已经严重残缺不全。在样线调查时,记录到两只死亡的斑头雁;另外,在紧邻样线附近的地方见到两只受伤的斑头雁和两只死亡的黑颈鹤。调查发现鸟类碰撞输电线多发生在靠近夜宿和觅食地的地方。我们建议,在位于碰撞敏感区(如夜宿地、觅食地以及有农田的河谷谷口的雁鹤飞行通道)的新旧输电线路增加颜色鲜艳的标志物,以便减少鹤类和雁类的碰撞。 | 李凤山 Mary Anne BISHOP 仓决卓玛 | 2011 | Chinese Birds2011，，4： | 7 |
| 14 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 15 | Advances in healthcare wearable devices显示文摘Wearable devices have found numerous applications in healthcare ranging from physiological diseases,such as cardiovascular diseases,hypertension and muscle disorders to neurocognitive disorders,such as Parkinson’s disease,Alzheimer’s disease and other psychological diseases.Different types of wearables are used for this purpose,for example,skin-based wearables including tattoobased wearables,textile-based wearables,and biofluidic-based wearables.Recently,wearables have also shown encouraging improvements as a drug delivery system;therefore,enhancing its utility towards personalized healthcare.These wearables contain inherent challenges,which need to be addressed before their commercialization as a fully personalized healthcare system.This paper reviews different types of wearable devices currently being used in the healthcare field.It also highlights their efficacy in monitoring different diseases and applications of healthcare wearable devices(HWDs)for diagnostic and treatment purposes.Additionally,current challenges and limitations of these wearables in the field of healthcare along with their future perspectives are also reviewed. | Sheikh M.A.Iqbal Imadeldin Mahgoub E Du Mary Ann Leavitt Waseem Asghar | 2021 | npj Flexible Electronics2021，5，1： | 6 |
| 16 | Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma显示文摘 | Mary Maluccio Anne Covey | 2012 | CA: A Cancer Journal for Clinicians2012，，6： | 6 |
| 17 | Advanced Glycation End Products: Sparking the Development of Diabetic Vascular Injury显示文摘 | Alison Goldin Joshua A. Beckman Ann Marie Schmidt Mark A. Creager | 2006 | Circulation2006，，6： | 5 |
| 18 | Intra-coronary administration of soluble receptor for advanced glycation end-products attenuates cardiac remodeling with decreased myocardial transforming growth factor-pl expression and fibrosis in minipigs with ischemia-reperfusion injury显示文摘 | LU Lin ZHANG Qi XU Yan ZHU Zheng-bin GENG Liang WANG Ling-jie JIN Cao CHEN Qiu-jing Ann Marie Schmidt SHEN Wei-feng | 2010 | Chinese Medical Journal2010，，5： | 5 |
| 19 | Roles and regulations of the ETS transcription factor ELF4/MEF显示文摘大多数 E26 转变特定(et ) 抄写因素涉及癌症的致病和前进。这是部分地由于在象生长,增长,和区别那样的基本生物进程的 et 抄写因素的角色,并且也因为他们在 tumorigenesis,免疫,和基础细胞的 homoeostasis 有生理的关联的规章的函数。象 E74 一样因素(矮子) 的一个成员 ETS 抄写因素 familymyeloid elf-1-like 因素(MEF ) 的亚科,指定了为 ELF4has 出现极其涉及有免疫力的反应并且发信号,成骨, adipogenesis,癌症,和干细胞静止。ELF4 作为 transcriptional 使活跃之物或通过和它的搭挡蛋白质的相互作用执行这些功能。在 ELF4 的变化引起异常相互作用并且导致可以导致 diseased 房间的下游的过程。知道 ELF4 怎么在某些细胞的过程上侵犯并且它怎么在房间被调整能导致调制 ELF4 活动的生理、病理学的后果的更好的理解。 | Mary Ann Suico Tsuyoshi Shuto Hirofumi Kai | 2017 | Journal of Molecular Cell Biology2017，9，3： | 5 |
| 20 | GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma显示文摘 | Jorge A. Marrero Patrick R. Romano Olga Nikolaeva Laura Steel Anand Mehta Claus J. Fimmel Mary Ann Comunale Anthony D’Amelio Anna S. Lok Timothy M. Block | 2005 | Journal of Hepatology2005，，6： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员