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    题名 作者 年代 出处 被引量
1黄芪总黄酮对扑热息痛所致肝损伤的防护机理探讨显示文摘目的 :研究黄芪总黄酮对扑热息痛所致肝损伤的防护机理。方法 :用高压液相测定扑热息痛及代谢产物和苯巴比妥诱导睡眠模型研究黄芪总黄酮 (TFA)对扑热息痛的代谢及TFA抗扑热息痛所致损伤的机理。结果 :TFA可明显降低尿中硫醚胺酸的浓度 ,其变化与TFA浓度成反比 ;但对其它代谢产物的影响无明显统计学差异。苯巴比妥诱导小鼠睡眠实验结果显示 ,TFA (10 0mg·kg-1)本身对苯巴比妥代谢无明显影响 (P >0 .0 5 ) ,扑热息痛 (40 0mg·kg-1)可显著延长小鼠的睡眠时间 (P <0 .0 0 1) ;但TFA (10 0mg·kg-1)明显缩短扑热息痛所延长的苯巴比妥诱导的睡眠时间 (P <0 .0 0 5 )。结论汪德清 Critchley Julian AJH 丁保国 马艳青 赵海潞 Thomas G Neil 田亚平 Tomlinson B rian Critchley Lester AH James Anthony Edward 2001中国中药杂志2001,26,9:13
2敲除诱导性一氧化氮合成酶治疗骨骼肌缺血再灌注损伤的实验研究显示文摘目的 研究敲除诱导性一氧化氮合成酶治疗骨骼肌缺血再灌注损伤的机制和作用。方法本实验采用敲除一氧化氮合成酶的小鼠 (治疗组 )及正常小鼠 (对照组 )各 2 1只 ,造成去神经游离提睾肌皮瓣完全缺血 3小时 ,在荧光显微镜下 ,活体动态观察该肌肉在恢复血液灌注前后 90分钟过程中平均微动脉管径的一系列变化 ,测量灌注前后肌肉的血恢复率 ,重量比率 ,并观察其病理变化。结果 (1)在灌注后 10和 90分钟 ,对照组小鼠肌肉的再灌注率分别为 (38 7± 18) %和 (6 3 8± 5 0 3) % ;而治疗组已达 (92 9± 17 2 ) %和 (10 8 7± 2 5 0 ) % (P <0 0 0 1)。 (2 )再灌注 10分钟时 ,对照组的平均微动脉管径始终维持在未缺血时的 5 1 5 %至 5 7 5 %之间 ,90分钟后分别达到 (71 6± 10 9) % (10~ 2 0um) ,(71 2± 15 1) % (2 1~ 4 0um) ,(6 3 4± 11 2 ) % (41~ 70um)。而治疗组再灌注 10分钟时的平均微动脉的管径即为缺血前的 72 % ,90分钟以后 ,分别达到 (91 8± 7 8) % (10~ 2 0um) ,(88 2± 7 6 ) % (2 1~ 4 0um ) ,(85 4± 6 6 ) % (41~ 70um) (P <0 0 0 1)。 (3)缺血 3小时再灌注 90分钟后 ,左、右两侧提睾肌的重量比 ,对照组为 (173 3± 4 4 5 ) % ,而治疗组为 (116 2± 7 7) % (P <0 0 1)。张俐 Anthony V.Seaber James R.Urbaniak 2002中国骨伤2002,15,3:11
3预防性中央区淋巴结清扫治疗甲状腺乳头状癌的利与弊显示文摘对甲状腺乳头状癌(PTC)的患者是否行预防性的中央区淋巴结清扫(pCND)是存在争议的。相比于其他恶性肿瘤而言,PTC患者有较好的整体生存率,但由于淋巴结的转移而导致局部复发也是治疗的一个难点。与颈侧区淋巴结转移不同,中央区淋巴结转移在术前评估中不易被发现,并且第1次术后如中央区的病灶复发或残留可能需再次手术治疗,但是出现手术并发症的风险将增加。由于中央区淋巴结在位置上属于甲状腺切除术的区域内,所以行pCND可以减少复发的风险及再次手术的需要,但也需要衡量患者的风险及获益。笔者将通过长期的治疗效果来讨论pCND的优势及劣势,同时也将对pCND的合理性,单或双侧pCND的指征及常规行pCND和复发再手术的比较进行讨论。分子标志物在高危患者中的应用及患者术后生存质量的研究也有所提及。Anthony R.Glover Justin S.Gundara Olov Norlén James C.Lee Stan B.Sidhu 冯铁成 李新营 2014中国普通外科杂志2014,23,5:10
4Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting.Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov 2014World Journal of Gastroenterology2014,20,45:9
5两种单氟磷酸钠牙膏预防乳牙龋病的2年临床研究显示文摘目的 :比较含氟浓度为 78.95 mmol/L (15 0 0 ppm)、磨料分别为碳酸钙及二氧化硅的二种单氟磷酸钠牙膏对儿童乳牙的临床防龋效果。方法 :采用随机双盲对照法 ,对四川省成都市 12 0 0名 4岁儿童进行了为期 2年的追踪研究。受试儿童被分为 3组 ,第 l组为含氟浓度 78.95 mmol/L、磨料为二氧化硅的单氟磷酸钠牙膏(MFP/Si O2 ) ,第 2组为含氟浓度 78.95 mmol/L、磨料为碳酸钙的单氟磷酸钠牙膏 (MFP/Ca CO3) ,第 3组为对照组 ,使用不含氟的碳酸钙牙膏。分析指标为乳牙龋面均 (dfs)增长数。结果 :998名儿童完成 2年的临床观察 ,1基线检查 3组的龋面均无显著性差异 ;2 l年后的龋面均增长数 :MFP/Si O2 组为 1.6 9± 3.12 ,MFP/Ca CO3组为1.5 3± 3.0 9,与对照组 2 .19± 4.12比较分别下降 30 .1%和 2 2 .8% ;3 2年后 MFP/Si O2 组和 MFP/Ca CO3组的龋面均增长数为 2 .98± 4.42及 2 .75± 4.33,与对照组 4.73± 5 .17比较分别下降 37%和 41.9% ,差异有显著性 ,两试验组之间统计学的差异无显著性。结论 :使用含 78.95 mmol/L氟浓度 ,磨料为二氧化硅或碳酸钙的单氟磷酸钠牙膏均有明显防龋效果 ,只要严格控制含氟牙膏的用量和加强管理 ,对发病率高的幼儿乳牙 ,不失为一种值得推广的安全而有效的防龋措施。范旭 万呼春 胡德渝 Yun PoZhang Bernal Stewart James McCool Margaret Petrone William De Vizio Anthony Volpe 2001实用口腔医学杂志2001,17,6:8
6Skin bioprinting:the future of burn wound reconstruction?显示文摘Burns are a significant cause of trauma,and over the years,the focus of patient care has shifted from just survival to facilitation of improved functional outcomes.Typically,burn treatment,especially in the case of extensive burn injuries,involves surgical excision of injured skin and reconstruction of the burn injury with the aid of skin substitutes.Conventional skin substitutes do not contain all skin cell types and do not facilitate recapitulation of native skin physiology.Three-dimensional(3D)bioprinting for reconstruction of burn injuries involves layer-by-layer deposition of cells along with scaffolding materials over the injured areas.Skin bioprinting can be done either in situ or in vitro.Both these approaches are similar except for the site of printing and tissue maturation.There are technological and regulatory challenges that need to be overcome for clinical translation of bioprinted skin for burn reconstruction.However,the use of bioprinting for skin reconstruction following burns is promising;bioprinting will enable accurate placement of cell types and precise and reproducible fabrication of constructs to replace the injured or damaged sites.Overall,3D bioprinting is a very transformative technology,and its use for wound reconstruction will lead to a paradigm shift in patient outcomes.In this review,we aim to introduce bioprinting,the different stages involved,in vitro and in vivo skin bioprinting,and the various clinical and regulatory challenges in adoption of this technology.Mathew Varkey Dafydd O.Visscher Paul P.Mvan Zuijlen Anthony Atala James J.Yoo 2019Burns & Trauma2019,7,1:8
7Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732).Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco 2012World Journal of Gastroenterology2012,18,26:6
8Double negative T cells,a potential biomarker for systemic lupus erythematosus显示文摘Systemic lupus erythematosus(SLE)is an autoimmune disease that is a challenge to diagnose and treat.There is an urgent need for biomarkers to help define organ involvement,and more effective therapies.A unique population of T cells,the CD3^(+)CD4^(−)CD8^(−)(DNeg)cells,is significantly increased in lupus patients.Twentyseven cases(53%)of pediatric SLE patients had elevated DNeg cells in their peripheral blood,which correlated with kidney function(R^(2)=0.54).Significant infiltration of DNeg cells was observed in both adult and pediatric lupus kidneys by immunofluorescence.For the first time,this study provides direct evidence that DNeg cells facilitate kidney injury in preclinical 8-week-old MRL/lpr lupus mice.In lupus mice,the increase in DNeg cells tracked with worsening disease and correlated with kidney function(R^(2)=0.85).Our results show that DNeg cells per se can cause kidney dysfunction,increase in number with increase in disease pathology,and could serve as a potential biomarker.Jessy J.Alexander Alexander Jacob Anthony Chang Richard J.Quigg James N.Jarvis 2020Precision Clinical Medicine2020,3,1:4
9基于Medipix的谱微CT(英文)显示文摘自从几十年前豪斯菲尔德因其突破性工作而赢得诺贝尔奖以来,X线CT已经被广泛的应用到了临床前以及临床应用,并产生了海量的灰度断层图像。由于其固有的光子计数问题涉及到较高的辐射剂量,这些灰度断层图像的软组织对比度差,经常难以提供一些关键性的细节而满足诊断的需要。从物理的角度来看,X线的谱是多能的,获得多能CT(亦被称为谱CT,真彩色CT)图像是可行的。这种谱图像提供了强有力的新诊断信息。近年来,新兴的Medipix技术提供了一种准确而快速的高分辨率能量选择的X线检测技术。本文将以我们小组的研究结果为重点来综述基于Medipix的谱微CT的研究进展。主要内容包括:先进的MediPix检测器,商业化MARS谱微CT的系统与方法,以及混合谱微CT的设计以及彩色扩散现象。James Bennett Raja Amir Bruce Dobbs 牟轩沁 魏彪 Anthony Butler Phillip Butler 2012CT理论与应用研究(中英文)2012,21,4:4
10Chemotherapy plus percutaneous radiofrequency ablation in patients with inoperable colorectal liver metastases显示文摘AIM:To access the efficacy of chemotherapy plus radiofrequency ablation(RFA)as one line of treatment in inoperable colorectal liver metastases.METHODS:Eligible patients were included in three PhaseⅡstudies.In the first study percutaneous RFA was used first followed by 6 cycles of 5-fluorouracil,leucovorin and irinotecan combination(FOLFIRI)(adjunctive chemotherapy trial).In the other two,chemotherapy(FOLFIRI or 5-fluorouracil,leucovorin and oxaliplatin combination)up to 12 cycles was used first with percutaneous RFA offered to responding patients (primary chemotherapy trials).RESULTS:Thirteen patients were included in the adjunctive chemotherapy trial and 17 in the other two.At inclusion they had 1-4 liver metastases(up to 6.5 cm in size).Two patients died during chemotherapy.All patients in the adjunctive chemotherapy trial and 44%in the primary chemotherapy studies had their metastases ablated.Median PFS and overall survival in the adjunctive study were 13 and 24 mo respectively while in the primary chemotherapy studies they were 10 and 21 mo respectively.Eighty one percent of the patients had tumour relapse in at least one previously ablated lesion.CONCLUSION:Chemotherapy plus RFA in patients with low volume inoperable colorectal liver metastases seems safe and relatively effective.The high local recurrence rate is of concern.Joseph Sgouros James Cast Krishna K Garadi Maria Belechri David J Breen John RT Monson Anthony Maraveyas 2011World Journal of Gastrointestinal Oncology2011,3,4:4
11Foreign direct investment as a catalyst for industrial development显示文摘James R. Markusen Anthony J. Venables 1999European Economic Review1999,,2:3
12国外甘蔗品种主要病害的分子和血清学检测初报显示文摘利用分子和血清学技术,对国外引进甘蔗品种进行了主要病害的检测,初步建立了规范化的国外甘蔗品种主要病害的检测技术体系。陈辉 James Anthony 范源洪 黄应昆 李文凤 2005中国糖料2005,27,1:3
13Difficulties and outcomes in starting endoscopic submucosal dissection显示文摘Anthony Yuen Bun Teoh Philip Wai Yan Chiu Simon Kin Hung Wong Joseph Jao Yiu Sung James Yun Wong Lau Enders Kwok Wai Ng 2010Surgical Endoscopy2010,,5:3
14The integrated use of chemical insecticides and the entomopathogenic nematode, Steinemema carpocapsae (Nematoda: Steinernematidae), for the control of sweetpotato whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae)显示文摘化学杀虫药剂的集成和 entomopathogenic 线虫 Steinernema carpocapsae (Wesier ) 的易传染的少年(Nematoda:Steinernematidae ) 到香甜的土豆白人苍蝇的控制第二中间形态, Bemisia tabaci Gennadius (半翅类:Aleyrodidae ) 被调查。用沙生物鉴定, S 的直接暴露的效果。为到到街郎 mellonella 幼虫的传染性上的四杀虫药剂(spiromesifen, thiacloprid, imidacloprid 和 pymetrozine ) 的地率冲淡的 24 h 的 carpocapsae 被测试。尽管除了 spiromesifen,测试的所有化学药品生产了可接受的线虫传染性率,他们都是显著地不到水控制。杀虫药剂处理的效果(spiromesifen, thiacloprid 和 pymetrozine 和土壤的干燥残余 imidacloprid 淋湿) 在对 B 的线虫的功效上。tabaci 也被调查。在有 thiacloprid 和 spiromesifen 的联合的线虫给了更高的 B。tabaci 死亡(86.5% 和 94.3% 分别地) 与独自使用线虫相比(75.2%) 在西红柿植物上。在 B 没有重要差别。tabaci 死亡当与独自使用化学药品相比与线虫一起使用化学药品 imidacloprid, pymetrozine 和 spiromesifen 时。然而,与线虫在联合使用 thiacloprid 生产了显著地更高的 B。tabaci 死亡与独自使用化学药品比。S 的集成。carpocapsae 和这些化学代理人进为 B 的控制的当前的综合害虫管理计划。tabaci 被讨论。Andrew G. S. Cuthbertson James J. Mathers Phil Northing Anthony J. Prickett Keith F. A. Waiters 2008Insect Science2008,15,5:3
15Current status and future applications of contrast-enhanced endoscopic ultrasonography显示文摘Endoscopic ultrasonography(EUS) is currently an in-tegral investigation of many gastrointestinal disorders.It has been shown to have a higher efficacy thanconventional computed tomography in detection andcharacterization of small lesions especially in the pan-creas. Much effort has been put to further improvethe sensitivity, specificity and overall accuracy of EUS.One of the major advances is the utilization of contrastagents for better delineation of the vascularity and tis-sue perfusion of the target lesion. This article describesthe basic principles of ultrasound contrast agents andthe different modalities used in contrast-enhanced EUS(CE-EUS) including contrast-enhanced Doppler EUS(CED-EUS) and contrast-enhanced harmonic EUS(CEH-EUS). In addition, the current applications of contrastenhanced EUS in different gastrointestinal conditionswere discussed. Furthermore, the future developmentof hybrid approaches combining CE-EUS with other im-aging modalities and the potential therapeutic aspectof using it as a vector for drug delivery were also dis-cussed.Hon Chi Yip Anthony Yuen Bun Teoh Charing Ching Ning Chong James Yun Wong Lau 2014World Journal of Gastrointestinal Endoscopy2014,6,4:3
16Efficacy of Linaclotide for Patients With Chronic Constipation显示文摘Anthony J. Lembo Caroline B. Kurtz James E. MacDougall B.J. Lavins Mark G. Currie Donald A. Fitch Brenda I. Jeglinski Jeffrey M. Johnston 2010Gastroenterology2010,,3:3
17Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation显示文摘Jeffrey M. Johnston Caroline B. Kurtz James E. MacDougall Bernard J. Lavins Mark G. Currie Donald A. Fitch Chris O’Dea Mollie Baird Anthony J. Lembo 2010Gastroenterology2010,,6:3
18Exploring Educator Values Alignment Strategies in an Intervention Context: The Emergence of the Beacon Strategy显示文摘Purpose:The purpose of this paper is to explore whether the four value alignment strategies available to educators(Scaffolding,Balancing,Intervention,and Refuge)previously identified in the mathematics education literature comprehensively capture educator value alignment strategies in an in terve ntion con text.Design/Approach/Methods:To this end,we analyse semi-structured interview data with two teacher-leaders involved in the Getting Ready in Numeracy(G.R.I.N.)intervention program through a value alignment lens.Findings:We ascertain that a fifth strategy,the Beacon strategy,is needed to describe the range of value alignment strategies employed by educators in the GRI.N.program.The Beacon strategy involves the educator digging in and reasserting their expectations until the student behaves in a manner that aligns with the educator's values.In part it invoIves the educator being able to recognize their own values and clearly communicating these values to students.O rigin al ity/Value:This article further explores strategies that educators have at their disposal for aligning their values with those of their students.The uncovering of the Beacon strategy is particularly valuable as it suggests that educators could be purposefully pursuing value alignment even when they do not appear to take any active steps to move further towards their students'sets of values.Penelope Kalogeropoulos James Anthony Russo Philip Clarkson 2021ECNU Review of Education2021,4,2:3
19Use of the Over-The-Scope Clip for treatment of refractory upper gastrointestinal bleeding: a case series显示文摘Shannon Chan Philip Chiu Anthony Teoh James Lau 2014Endoscopy2014,,:2
20机械挤压对大鼠血管内皮细胞一氧化氮合酶表达的调节作用显示文摘目的 :探讨机械挤压大鼠腿部致微循环改变与一氧化氮合酶 (NOS)表达之间的关系。方法 :采用间歇性气囊挤压袋 (IPC)挤压大鼠腿部。将 2 5只雄性SD大鼠随机分为 4个IPC实验组和 3个模拟组 ,4个IPC组分别挤压 0 .5、1、 5h和挤压 1h再等待 4h,3个模拟实验组处理方法与IPC组相同但不挤压。应用RT PCR、WestenrBlot和免疫组化方法检测了IPC作用前后 ,挤压部位的肌肉———胫前肌 (AT)和未挤压部位的肌肉———提睾肌 (CM)中内皮细胞型一氧化氮合酶 (eNOS)的表达。结果 :在IPC作用的不同时间段上 ,eNOSmRNA和蛋白在AT和CM中均有显著上升 ,在IPC作用 1h ,然后再等待 4h的实验组中 ,eNOSmRNA和蛋白又恢复至正常对照水平。结论 :IPC产生的机械压力增加了血管内皮细胞的剪切力 ,刺激该细胞NOS合成增加 ,进而增加了NO产物的释放量 ,使血管扩张 ,改善了局部微循环。谭湘陵 陈隆恩 齐文宁 Anthony V.Seaber James R.Urbaniak 2001微循环学杂志2001,11,3:2
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