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| 1 | Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma显示文摘瞄准:为了评估免疫, interleukin-6 ( IL-6 )和从有肝细胞癌( HCC )和浆液的病人的肿瘤组织标本上的 IL-6 受体( IL-6R )的组织化学的本地化与 HCC 以及肝肝硬化( LC )在一组病人 IL-6 和 sIL-6R 铺平在一组有独自一个的 LC 并且在一个控制组的病人。方法:三组题目被学习:组我(n = 83 ) 受不了 HCC 和 LC,组 II (n = 72 ) 受不了独自一个的 LC 和组 III (n = 42 ) 同样健康的控制。所有病人有丙肝病毒感染。浆液 IL-6 和 IL-6R 层次用一个商业地可得到的 ELISA 工具包被决定。Immunohistochemistry 对 IL-6 和 IL-6R 用 streptavidin-biotin 建筑群和兔子 polyclonal 抗体被执行。结果:Immunohistochemistry 分析显示出媒介到强壮细胞质并且为 IL-6 和 IL-6R 的膜反应分别地在 HCC 的至少 40% 盒子,而肝肝硬化病人和控制为 IL-6 是否定的或为 IL-6R 显示出很温和、焦点的像点的细胞质的反应。在 HCC 组的浆液 IL-6 层次比在 LC 和控制组的那些显著地高(P <
0.0001 ) 。在在 3 个组之中的 sIL-6R 集中没有有效差量。当有 HCC 的病人根据 Okuda 的分类被划分成组时, IL-6 和 sIL-6R 水平的重要浆液增加从舞台被观察我上演 III (P <
0.02, P <
0.0005 ) 。当 HCC 和 LC 病人根据孩子呸被划分成肝硬化严厉的 3 个班时,在 HCC 病人的价值比在为各相应的班的 LC 病人的那些显著地高(P <
0.01 ).CONCLUSION:在 HCC 病人的 IL-6 浆液层次比在 LC 病人和控制的那些高,建议由肿瘤的房间的这 cytokine 的增加的生产。sIL-6R 价值在所有组是类似的,仅仅在阶段 III HCC 病人增加。这些数据建议他们与肿瘤的团而非与剩余的工作有一种更靠近的关系肝的质量。 | Soresi Maurizio Giannitrapani Lydia D'Antona Fabio Florena Ada Maria La Spada Emanuele Terranova Angela Cervello Melchiorre D'Alessandro Natale Montalto Giuseppe | 2006 | World Journal of Gastroenterology2006，12，16： | 25 |
| 2 | Diagnostic performance of serum interleukin-6 in pediatric acute appendicitis:a systematic review显示文摘Background Despite the radiological and analytical advances of the last decades,there is still a significant rate of diagnostic error in pediatric acute appendicitis.In recent years,multiple biomarkers have emerged as potential diagnostic tools.This study aimed to examine the diagnostic performance of serum interleukin-6 in pediatric acute appendicitis.Methods We conducted a systematic review of the literature that involved an extensive search in the main databases of medical bibliography(Medline,PubMed,Web of Science and SciELO).Two independent reviewers selected the relevant articles based on the previously defined inclusion and exclusion criteria.Methodological quality of the selected article was rated using the QUADAS2 index.Data extraction was performed by two independent reviewers.Results The research in the medical bibliography databases resulted in 68 articles.We removed 26 duplicates.Among the remaining 42 articles,we excluded 33 following the inclusion and exclusion criteria.Of the final 9 studies included in this review,8 provided measured serum interleukin-6 values,and all of them reported significant differences between groups,but inconsistent results regarding sensitivity and specificity.Conclusions The diagnostic performance of interleukine-6 alone for the diagnosis of acute appendicitis in children is limited.The sensitivity and specificity of interleukine-6 for the diagnosis of non-complicated acute appendicitis in the pediatric population are moderate but increased in complicated appendicitis.There seems to be a direct relationship between serum level of interleukin-6 and the hours of evolution of abdominal pain in children with acute appendicitis.The increasingly widespread use of non-operative management of acute appendicitis warrants further exploration of the classificatory potential of this marker between complicated and uncomplicated appendicitis.We consider that this may be an avenue of research to explore in the future. | Javier Arredondo Montero Carlos Bardaji Pascual Monica Bronte Anaut Natalia Lopez-Andres Giuseppa Antona Nerea Martin-Calvo | 2022 | World Journal of Pediatrics2022，18，2： | 3 |
| 3 | The value of FeNO measure- ment in childhood asthma:uncertainties and perspectives 显示文摘 | Ferrante G Malizia V Antona R | 2013 | Mul- tidiscip Respir Med2013，8，1： | 1 |
| 4 | The effect of 'high dose' aprotinin and other factors on bleeding and revisions for bleeding in aduh coronary and valve operations :an analysis of 2190 patients during a five-year period显示文摘 | Parolari A Antona C Gerometta P | 1995 | Eur J Cardiothorac Surg1995，9，6： | 1 |
| 5 | Respira-tory muscle fibres:specialisation and plasticity显示文摘 | Polla B D’Antona G Bottinelli R | 2004 | Thorax2004，59，9： | 1 |
| 6 | Proce- ssing magnetic sensor array data for AC current measurement in multiconductor systems 显示文摘 | Gabriele D' Antona Luca Di Rienzo Roberto Ottoboni | 2001 | IEEE Transactions on Instrumenta- tion and Measurement2001，50，5： | 1 |
| 7 | Activin A as a marker of intrauterine infection in women with preterm prelabour rupture of membranes显示文摘 | Hodges R Salvador L D'Antona D Georgiou HM Wallace EM | 2010 | J Perinatol2010，30，1： | 1 |
| 8 | 查看详情显示文摘 | D'Antona F Mazzitelli I | | 0，，： | 1 |
| 9 | Facioscapulohumeral Muscular Dystrophy in Mice Overexpressing FRGI 显示文摘 | GABELLINI D D'ANTONA G MOGGIO | 2006 | Nature2006，439，： | 1 |
| 10 | Levosimendan:A review of its use in the management of acute decompensated heart failure显示文摘 | Careen A I Antona J W | 2003 | Drugs2003，63，23： | 1 |
| 11 | Clenbuterol antagonizes glucocorticoid-induced atrophyand fibre type transformation in mice 显示文摘 | PELLEGRINO M A D ANTONA G BORTOLOTTO S | 2004 | Exp Physiol?2004，89，1： | 1 |
| 12 | Branched-chain amino acid supplementation promotessurvival and supports cardiac and skeletal muscle mi-tochondrial biogenesis in middle-aged mice 显示文摘 | D1 ANTONA G RAGNI M CARDILE A | 2010 | CellMetabolism2010，12，4： | 1 |
| 13 | Comparison of n-3 polyunsatu- rated fatty acid contents of wild and cultured Australian aba- lone显示文摘 | Su X Q Antonas K N Li D | 2004 | Int J Food Sci Nutr2004，55，2： | 1 |
| 14 | Update on best available options in obstetrics anaesthesia: perinatal outcomes, side effects and maternal satisfaction. Fifteen years systematic literature review显示文摘 | Salvatore Gizzo Marco Noventa Simone Fagherazzi Laura Lamparelli Emanuele Ancona Stefania Gangi Carlo Saccardi Donato D’Antona Giovanni Battista Nardelli | 2014 | Archives of Gynecology and Obstetrics2014，，： | 1 |
| 15 | Surveillance of enteroviruses in France, 2000-2004 显示文摘 | Antona D Leveque N Chomel JJ | 2007 | Eur J Clin Microbial Infect Dis2007，26，6： | 1 |
| 16 | Orthologous myosin isoforms and scaling of shortening velocity with body size in mouse, rat, rabbit and human muscles显示文摘 | Pellegrino M A Canepari M Rossi R D'Antona G Reggiani C Bottinelli R | 2003 | The Journal of Physiology2003，546，： | 1 |
| 17 | Maternal serum inhibin A levels may predict pregnancy outcome in women with threatened abortion 显示文摘 | Florio P Luisi S D' Antona D | 2004 | Fertil Steril2004，81，2： | 1 |
| 18 | Comparison of n-3 polyunsaturated fatty acid contents of wild and cultured Australian abalone显示文摘 | Su X Q Antonas K N Li D | 2004 | International Journal of Food Science and Nutrition2004，55，： | 1 |
| 19 | Chloroperoxidase from Caldariomycesfumago is active in the presence of an ionic liquid as co-solvent 显示文摘 | Sanfilippo C D 'Antona N Nicolosi G | 2004 | Biotechnol Lett2004，26，23： | 1 |
| 20 | Late fetal heart decelerations and changes in cerebral oxygenation during the first stage of labour显示文摘 | Aldrich CJ D'Antona D Spencer JA | 1995 | Br J Obstet Gynecol1995，102，： | 1 |
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