|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The presence of ANP in rat peritoneal mast cells显示文摘Atrial natriuretic peptide (ANP) is an important component of the natriuretic peptide system. A great role in many regulatory systems is played by mast cells. Meanwhile involvement of these cells in ANP activity is poorly studied. In this work, we have shown the presence of ANP in rat peritoneal mast cells. Pure fraction of mast cells was obtained by separation of rat peritoneal cells on a Percoll density gradient. By Western blotting, two ANP-immunoreactive proteins of molecular masses of 2.5 kDa and 16.9 kDa were detected in lysates from these mast cells. Electron microscope immunogold labeling has revealed the presence of ANP-immunoreactive material in storage, secreting and released granules of mast cells. Our findings indicate the rat peritoneal mast cells to contain both ANP prohormone and ANP. These both peptides are located in mast cell secretory granules and released by mechanism of degranulation. It is discussed that many mast cell functions might be due to production of natriuretic peptides by these cells. | Marina G MARTYNOVA Olga A BYSTROVA Olga M MOISEEVA Anton L EVDONIN Kirill A KONDRATOV Natalja D MEDVEDEVA | 2005 | Cell Research2005，15，10： | 3 |
| 2 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 3 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 4 | Role of GGF/Neuregulin Signaling in Interactions between Migrating Neurons and Radial Glia in the Developing Cerebral Cortex显示文摘 | Anton E S Marehionni M A Lee K F | 1997 | Development1997，124，18： | 1 |
| 5 | Predicting the result of noninvasive ventilation in sereve acute exacerbations of patients with chronic airflow limitation显示文摘 | Anton A Gunell R Gomez J | 2000 | Chest2000，117，： | 1 |
| 6 | Isocyanoacetate derivatives: Synthesis, reactivity, and application 显示文摘 | Anton V G Alexander G Z Romano V A O | 2010 | Chem Rev2010，110，： | 1 |
| 7 | The heterogeneous advantage:biodiesel by catalytic reactive distillation显示文摘 | KISS ANTON A FLORIN OMOTA DIMIAN ALEXANDRE C | 2006 | Topics in Catalysis2006，40，： | 1 |
| 8 | A biologically inspired ray-like underwater robot with electroactive polymer pectoral Fins 显示文摘 | Punning A Anton M Kruusmaa M | 2004 | IEEE Mechatronics and Robotics2004，，2： | 1 |
| 9 | Domaim in the S-layer protein Cbs A of Lactobacinus crispatus involved in adherence to collagens,larmmn and lipoteichoic acids and in self-assembly显示文摘 | Antikanen J Anton L Sillanpaa J et a/ | 2002 | Mol Microbiol2002，46，： | 1 |
| 10 | Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability显示文摘 | Marusic L Anton M Tidy A | | 0，，： | 1 |
| 11 | Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles显示文摘 | David Cunningham Eliza A Hawkes Andrew Jack Wendi Qian Paul Smith Paul Mouncey Christopher Pocock Kirit M Ardeshna John A Radford Andrew McMillan John Davies Deborah Turner Anton Kruger Peter Johnson Joanna Gambell David Linch | 2013 | The Lancet2013，，9880： | 1 |
| 12 | Biodiesel by catalytic reactive distillation powered by metal oxides显示文摘 | KISS ANTON A DIMIAN ALEXANDRE C GADI ROTHENBERG | 2008 | Energy & Fuels2008，22，： | 1 |
| 13 | Assessment of quality as perceived by users of an outpatient pharmaceutical care unit显示文摘 | ANTON T R MURCIA L A BORRAS B J | 2006 | Farm Hosp2006，30，2： | 1 |
| 14 | Inquiry-based Requirements Analysis显示文摘 | Potts C Takahashi K Anton A I | 1994 | IEEE1994，，3： | 1 |
| 15 | Morphine,5-HT2 and 5-HT3 receptor antagonists reduce c-fos expression in the trigeminal nucear complex following noxious chemical stimulation of the rat nasal mucosa显示文摘 | Ebersberger A Anton F Tolle TR | 1995 | Brain Res1995，676，2： | 1 |
| 16 | Reactive dividing-wall columns-how to get more with less resources?显示文摘 | Kiss Anton A Pragt J J | 2009 | Chemical Engineering Communications2009，196，11： | 1 |
| 17 | Vaccines against morphine/heroin and its use as effective medication for preventing relapse to opiate addictive behaviors显示文摘 | Anton B Salazar A Flores A | 2009 | Human Vaccines2009，5，： | 1 |
| 18 | Pharmacogenomics in lung cancer:an analysis of DNA repair gene expression in patients treated with platinum-based chemotherapy显示文摘 | Garcia C R Alonso C G Anton A | 2005 | Expert Opin Pharmacother2005，6，12： | 1 |
| 19 | A placebo-controlled trial of buspirone in anxious in putient alcoholics显示文摘 | Malcolm R Anton RF Randall CL Thevos A | 1992 | Alcohol Clin Exp Res1992，16，6： | 1 |
| 20 | The rheologieal behavior of some binders and plastics used in injection molding显示文摘 | NOVAC O A ANTON D NOVAC T | 1994 | Powder Metallurgy1994，94，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员