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| 1 | Chronic intestinal pseudo-obstruction显示文摘Chronic intestinal pseudo-obstruction (CIPO) is a se- vere digestive syndrome characterized by derangement of gut propulsive motility which resembles mechanical obstruction, in the absence of any obstructive process. Although uncommon in clinical practice, this syndrome represents one of the main causes of intestinal failure and is characterized by high morbidity and mortality. It may be idiopathic or secondary to a variety of diseases. Most cases are sporadic, even though familial forms with either dominant or recessive autosomal inheritance have been described. Based on histological features in- testinal pseudo-obstruction can be classified into three main categories:neuropathies, mesenchymopathies, and myopathies, according on the predominant involvement of enteric neurones, interstitial cells of Cajal or smooth muscle cells, respectively. Treatment of intestinal pseu- do-obstruction involves nutritional, pharmacological and surgical therapies, but it is often unsatisfactory and the long-term outcome is generally poor in the majority of cases. | Alexandra Antonucci Lucia Fronzoni Laura Cogliandro Rosanna F Cogliandro Carla Caputo Roberto De Giorgio Francesca Pallotti Giovanni Barbara Roberto Corinaldesi Vincenzo Stanghellini | 2008 | World Journal of Gastroenterology2008，14，19： | 12 |
| 2 | untreatable hepatocellular 癌的自然历史: 回顾的队研究显示文摘 AIM:To investigate the clinical course of untreatable hepatocellular carcinoma(HCC) identified at any stage and to identify factors associated with mortality.METHODS:From January 1999 to December 2010,320 out of 825 consecutive patients with a diagnosis of HCC and not appropriate for curative or palliative treatments were followed and managed with supportive therapy.Cirrhosis was diagnosed by histological or clinical features and liver function was evaluated according to Child-Pugh score.The diagnosis of HCC was performed by Ultra-Sound guided biopsy or by multiphasic contrast-enhanced computed tomography or gadolinium-enhanced magnetic resonance imaging.Data were collected for each patient including all clinical,laboratory and imaging variables necessary for the outcome prediction staging systems considered.HCC staging was performed according Barcelona Clinic Liver Cancer(BCLC) and Cancer of the Liver Italian Program scores.Follow-up time was defined as the number of months from the diagnosis of HCC to death.Prognostic baseline variables were analyzed by multivariate Cox analysis to identify the independent predictors of survival.RESULTS:Seventy-five per cent of patients had hepatitis C.Ascites was present in 169 patients(53%),while hepatic encephalopathy was present in 49 patients(15%).The Child-Pugh score was class A in 105 patients(33%),class B in 142 patients(44%),and class C in 73 patients(23%).One hundred patients(31%) had macroscopic vascular invasion and/or extrahepatic spread of the tumor.A single lesion > 10 cm was observed in 34 patients(11%),while multinodular HCC was present in 189 patients(59%).Thirty nine patients(12%) were BCLC early(A) stage,55(17%) were BCLC intermediate(B) stage,124(39%) were BCLC advanced(C) stage,and 102(32%) were endstage BCLC(D).At the time of this analysis(July 2011),28(9%) patients were still alive.Six(2%) patients who were lost during follow-up were censored at the last visit.The overall median survival was 6.8 mo,and the 1-year survival was 32%.The 1-year survival according to BCLC classes was 100%,79%,12% and 0%,for BCLC A,B,C and D,respectively.There was a significant difference in survival between each BCLC class.The median survival of patients of BCLC stages A,B,C and D was 33,17.4,6.9,and 1.8 mo,respectively(P < 0.05 for comparison between stages).The median survival of Child-Pugh A,B and C classes were 9.8 mo(range 6.4-13),6.1(range 4.9-7.3),and 3.7(range 1.5-6),respectively(P < 0.05 for comparison between stages).By univariate analysis,the variables significantly associated to an increased liklihood of mortality were Eastern Cooperative Oncology Group performance status(PS),presence of ascites,low level of albumin,elevated level of bilirubin,international normalized ratio(INR) and Log-[(α fetoprotein(AFP)].At multivariate analysis,mortality was independently predicted by bad PS(P < 0.0001),high INR values(P = 0.0001) and elevated Log-(AFP) levels(P = 0.009).CONCLUSION:This study confirms the heterogeneous behavior of untreated HCC.BCLC staging remains an important prognostic guide and may be important in decision-making for palliative treatment. | Giuseppe Cabibbo Marcello Maida Chiara Genco Pietro Parisi Marco Peralta Michela Antonucci Giuseppe Brancatelli Calogero Cammà Antonio Craxì Vito Di Marco | 2012 | World Journal of Hepatology2012，4，9： | 11 |
| 3 | Evaluation of three-dimensional biofilms on antibacterial bonding agents containing novel quaternary ammonium methacrylates显示文摘Antibacterial adhesives are promising to inhibit biofilms and secondary caries.The objectives of this study were to synthesize and incorporate quaternary ammonium methacrylates into adhesives,and investigate the alkyl chain length effects on three-dimensional biofilms adherent on adhesives for the first time.Six quaternary ammonium methacrylates with chain lengths of 3,6,9,12,16 and 18were synthesized and incorporated into Scotchbond Multi-Purpose.Streptococcus mutans bacteria were cultured on resin to form biofilms.Confocal laser scanning microscopy was used to measure biofilm thickness,live/dead volumes and live-bacteria percentage vs.distance from resin surface.Biofilm thickness was the greatest for Scotchbond control;it decreased with increasing chain length,reaching a minimum at chain length 16.Live-biofilm volume had a similar trend.Dead-biofilm volume increased with increasing chain length.The adhesive with chain length 9 had 37%live bacteria near resin surface,but close to 100%live bacteria in the biofilm top section.For chain length 16,there were nearly 0%live bacteria throughout the three-dimensional biofilm.In conclusion,strong antibacterial activity was achieved by adding quaternary ammonium into adhesive,with biofilm thickness and live-biofilm volume decreasing as chain length was increased from 3 to 16.Antibacterial adhesives typically only inhibited bacteria close to its surface;however,adhesive with chain length 16 had mostly dead bacteria in the entire three-dimensional biofilm.Antibacterial adhesive with chain length 16 is promising to inhibit biofilms at the margins and combat secondary caries. | Han Zhou Michael D Weir Joseph M Antonucci Gary E Schumacher Xue-Dong Zhou Hockin H K Xu | 2014 | International Journal of Oral Science2014，6，2： | 5 |
| 4 | Enhancing bioelectricity generation in microbial fuel cells and biophotovoltaics using nanomaterials显示文摘Microbial fuel cells and biophotovoltaics represent promising technologies for green bioelectricity generation.However,these devices suffer from low durability and efficiency that stem from their reliance on living organisms to act as catalysts.Such limitations can be overcome with augmented capabilities enabled by nanotechnology.This review presents an overview of the different nanomaterials used to enhance bioelectricity generation through improved light harvesting,extracellular electron transfer,and anode performance.The implementation of nanomaterials in whole-cell energy devices holds promise in developing bioelectrical devices that are suitable for industry. | Mohammed Mouhib Alessandra Antonucci Melania Reggente Amirmostafa Amirjani Alice J. Gillen Ardemis A.Boghossian | 2019 | Nano Research2019，12，9： | 4 |
| 5 | Over-the-scope clips in the treatment of gastrointestinal tract iatrogenic perforation: A multicenter retrospective study and a classification of gastrointestinal tract perforations显示文摘AIM: To determine the outcome of the management of iatrogenic gastrointestinal tract perforations treated by over-the-scope clip(OTSC) placement.METHODS: We retrospectively enrolled 20 patients(13 female and 7 male; mean age: 70.6 ± 9.8 years) in eight high-volume tertiary referral centers with upper or lower iatrogenic gastrointestinal tract perforation treated by OTSC placement. Gastrointestinal tract perforation could be with oval-shape or with round-shape. Ovalshape perforations were closed by OTSC only by suction and the round-shape by the 'twin-grasper' plus suction. RESULTS: Main perforation diameter was 10.1 ± 4.3 mm(range 3-18 mm). The technical success rate was 100%(20/20 patients) and the clinical success rate was 90%(18/20 patients). Two patients(10%) who did not have complete sealing of the defect underwent surgery. Based upon our observations we propose two types of perforation: Round-shape 'type-1 perforation' and oval-shape 'type-2 perforation'. Eight(40%) out of the 20 patients had a type-1 perforation and 12 patients a type-2(60%). CONCLUSION: OTSC placement should be attempted after perforation occurring during diagnostic or therapeutic endoscopy. A failed closure attempt does not impair subsequent surgical treatment. | Benedetto Mangiavillano Angelo Caruso Raffaele Manta Roberto Di Mitri Alberto Arezzo Nico Pagano Giuseppe Galloro Filippo Mocciaro Massimiliano Mutignani Carmelo Luigiano Enrico Antonucci Rita Conigliaro Enzo Masci | 2016 | World Journal of Gastrointestinal Surgery2016，8，4： | 3 |
| 6 | Identification of the second CFTR mutation in patients with congenital bilateral absence of vas deferens undergoing ART protocols显示文摘管 deferens (CBAVD ) 的先天的双边的缺席是膀胱的纤维变性(CF ) 的最轻微的形式的表明并且被妨碍的精子缺乏在不那样健康的病人描绘。由于帮助繁殖技术的可获得性, CBAVD 病人能生孩子。这些父亲在播送 CF transmembrane 传导力管理者(CFTR ) 的变异的等位基因的风险基因,为 CF 负责,到他们的后代。在在 CBAVD 病人的两 CFTR 等位基因的变化的鉴定是为如果女搭挡是一个健康 CF 搬运人,计算与全面 CF 生产一个孩子的风险的一个关键要求。在 CBAVD 病人的多数,然而,常规变化屏蔽不能在两 CFTR 等位基因检测变化,并且这个困难妨碍正确基因 counselling 的实行。为了关于大多数获得信息,在 CBAVD 病人代表了 CFTR 变化,我们分析了 23 个 CBAVD 病人,其中 15 个在为 36 个变化和 5T 等位基因屏蔽以后有一个单个 CFTR 变化。为在这些情况中的第二个 CFTR 变化的搜索被使用一条三重的途径执行:(i) 第一,反向的点污点分析被执行与地区性的影响检测变化;(ii ) 下次,多重结扎依赖者探查扩大试金被进行寻找大重新整理;并且(iii ) 最后,使中毒高效的液体层析被用来在全部编码区域寻找点变化。用这些途径,第二个 CFTR 变化在六个病人被检测,它增加了最后的察觉率到 60.8% 。 | Rossella.Giuliani Ivana Antonucci Isabella Torrente Paola Grammatico Giandomenico Palka Liborio Stuppia | 2010 | Asian Journal of Andrology2010，12，6： | 3 |
| 7 | Preventing medication errors in neonatology: Is it a dream?显示文摘Since 1999, the problem of patient safety has drawn particular attention, becoming a priority in health care. A 'medication error'(ME) is any preventable event occurring at any phase of the pharmacotherapy process(ordering, transcribing, dispensing, administering, and monitoring) that leads to, or can lead to, harm to the patient. Hence, MEs can involve every professional of the clinical team. MEs range from those with severe consequences to those with little or no impact on the patient. Although a high ME rate has been found in neonatal wards, newborn safety issues have not been adequately studied until now. Healthcare professionals working in neonatal wards are particularly susceptible to committing MEs due to the peculiarities of newborn patients and of the neonatal intensive care unit(NICU) environment. Current neonatal prevention strategies for MEs have been borrowed from adult wards, but many factors such as high costs and organizational barriers have hindered their diffusion. In general, two types of strategies have been proposed: the first strategy consists of identifying human factors that result in errors and redesigning the work in the NICU in order to minimize them; the second one suggests to design and implement effective systems for preventing errors or intercepting them before reaching the patient. In the future, prevention strategies for MEs need to be improved and tailored to the special neonatal population and the NICU environment and, at the same time, every effort will have to be made to support their clinical application. | Roberto Antonucci Annalisa Porcella | 2014 | World Journal of Clinical Pediatrics2014，3，3： | 3 |
| 8 | 六边体系显示文摘HEX-SYS/六边体系是OPEN建筑事务所研发的灵活可拆装建筑体系.作为对中国近年来伴随着建造热潮而出现的大量临时建筑的回应,这个可快速建造、可重复使用的建筑体系延长了建筑的生命周期,实现了真正意义上的可持续性.预制化生产和装配式建造,使其像产品样具备批量生产的可能:而通过模块的不同组合方式,它又会演化出各种各样的版本,灵活适用于不同的场地和功能. | 李虎 黄文菁 赵耀 Andrea Antonucci 陈逸岚 胡伯骥 Thomas Bazenschlager 张畅 张超(摄影) 无 | 2016 | 建筑学报2016，，6： | 2 |
| 9 | Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?显示文摘 | Dario Siniscalco Anna Sapone Alessandra Cirillo Catia Giordano Sabatino Maione Nicola Antonucci Ken-ichi Isobe | 2012 | Journal of Biomedicine and Biotechnology2012，，： | 2 |
| 10 | A multilayer grating spectrometer for solar observations显示文摘 | E Antonucci L Ciminiera A M Malvezzi | 1998 | SPIE1998，3443，： | 1 |
| 11 | Effect of bifunetional comonomers on mechanical strength and water sorption of amorphous calcium phosphate-and silanized glass-filled his GMA based composites 显示文摘 | Skrtica D Antonucci J M | 2003 | Biomaterials2003，24，： | 1 |
| 12 | Adhensive bonding of various materials to hard tooth tissues: XIII synthesis of a polyfunctional surface-active amine accelerator 显示文摘 | Antonucci J M Bowen R L | 1977 | J Dent Res1977，56，8： | 1 |
| 13 | Dimethacrylate monomers with var- ied fluorine contents and distributions 显示文摘 | Stansbury JW Antonucci JM | 1999 | Dent Mater1999，15，3： | 1 |
| 14 | An Examination of Sex Differences in Social Support among Older Men and Women显示文摘 | Antonucci TC Akiyama H | 1987 | Sex Roles1987，，17： | 1 |
| 15 | Stereovision system for estimating tractors and agricultural machines transit area under orchards canopy显示文摘Managing orchards requires delicate agricultural operations being typically carried out in narrow zones where the operators usually drive machineries under stress that could result in poor performance.In such conditions,the use of technology would help manage the machines to reduce the hazardous work and eventual damage to the plants.To safely drive a tractor,the driver needs to be aware of its surroundings,thus a stereovision system can provide helpful information.Stereo imaging has proven to be an effective three-dimensional vision system.Indeed,the range(or third coordinate)information is useful to detect the obstacle distances.Such distances,when detected during agricultural operations,could be used to assist the operator in driving the tractor at regular or variable working speeds and eventually to provide manufacturers useful indications to model the form of ROPS(roll over protection structure).This study aimed to verify the closeness of agreement between manual and stereo-image measurements,and thus to provide helpful information regarding safety and working purposes.The system used a custom low-cost dual web-camera in combination with an image analysis algorithm in order to automatically extract the information needed.Manual independent measurements were carried out using a metric tape(sensitivity 1 cm).A regular structure was used for the analysis:four rows of ten trees each one.Alternated red and blue paper markers were placed on the hazelnut trees(two per tree)of two couples of rows for enhanced visibility.For each couple of trees(one on the right,the other on the left),the four markers formed a trapezoid that was measured.The results of the analysis demonstrated that the stereo vision provided distance measurements with reasonable accuracy(error<5%)in the range of distances lower than 20 m.The resolution assessed for the developed video system is suitable for obtaining distance information in real scenes.This information could be used to assist drivers to operate agricultural machineries through narrow tree rows during work execution.Moreover,such information could be used for safeguarding decision-making and/or for controlling some tractor functions such as continuing moving,changing driving direction,changing 3-point hitch position,reducing transmission speed,halting the tractor.These functions will be necessary before tractors become fully autonomous.Finally,the measured distances,marking the narrow transitions between the tree rows,could be also used to study the ROPS form,both for working safely and for avoiding possible damage caused to the hazel trees laterally. | Corrado Costa Paolo Febbi Federico Pallottino Massimo Cecchini Simone Figorilli Francesca Antonucci Paolo Menesatti | 2019 | International Journal of Agricultural and Biological Engineering2019，12，1： | 1 |
| 16 | Subarachnoid sufentanil as sole agent vs standard spinal bupivacaine in transurethral resection of the bladder显示文摘 | Antonucci A Tellan G | 2005 | Minerva Anestesiol2005，71，3： | 1 |
| 17 | Preventive therapy for tuberculosis in HIV-infected persons: Analysis of policy options based on tuberculin status and CD4+cell count显示文摘 | Sawert H Girardi E Antonucci G Raviglione MC Viale P Ippolito G | 1998 | Arch Interm Med1998，158，： | 1 |
| 18 | Cognitive rehabililation of the hemineglect discarder in chronic patients with unilateral right brain damage显示文摘 | Pizzamiglio L Antonucci G Judica A | 1992 | Journal of Clininical Experimentat Neuropsychology1992，14，6： | 1 |
| 19 | Methanol oxidation on carbon-supported platinum-tin electrodes in sulfuric acid显示文摘 | ARICO A S ANTONUCCI V GIORDANO N | 1994 | J Power Sources1994，50，： | 1 |
| 20 | ACimpendance spectroscopy of porous gas diffusion electrode in sulphunic acid显示文摘 | ARICO A S ALDERUCCI V ANTONUCCI V FERRARA S RECUPERO V GIORDANO N KINOSHITA K | 1992 | ElectrochimActa1992，37，： | 1 |
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