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| 1 | Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation显示文摘BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young children.Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.AIM To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT.METHODS We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative complications.The receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/kg.Subsequently,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be analyzed.RESULTS High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up period.During a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the LTr.Over a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection complications.Additionally,Cox hazard regression found that high-volume RBC transfusion increased the mortality risk by 3.031-fold compared to low-volume transfusion.The Kaplan-Meier survival curves of the studied groups were compared using log-rank tests and the analysis showed significantly decreased graft survival,but with no impact in patient survival related to major complications.On the other hand,there was a significant decrease in both graft and patient survival,with high-volume RBC transfusion.CONCLUSION Transfusion of RBC volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short-and long-term postoperative morbidity and mortality after PLDLT. | Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque | 2021 | World Journal of Gastroenterology2021，27，12： | 6 |
| 2 | Beneficial effects of adenosine triphosphate-sensitive K^+ channel opener on liver ischemia/reperfusion injury显示文摘AIM:To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury.METHODS:Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation.They were divided into 3 groups:Control Group,rats submitted to liver manipulation,Saline Group,rats received saline,and Diazoxide Group,rats received intravenous injection diazoxide(3.5 mg/kg) 15 min before liver reperfusion.4 h and 24 h after reperfusion,blood was collected for determination of aspartate transaminase(AST),alanine transaminase(ALT),tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),nitrite/nitrate,creatinine and tumor growth factor-β1(TGF-β1).Liver tissues were assembled for mitochondrial oxidation and phosphorylation,malondialdehyde(MDA) content,and histologic analysis.Pulmonary vascular permeability and myeloperoxidase(MPO) were also determined.RESULTS:Four hours after reperfusion the diazoxide group presented with significant reduction of AST(2009 ± 257 U/L vs 3523 ± 424 U/L,P = 0.005); ALT(1794 ± 295 U/L vs 3316 ± 413 U/L,P = 0.005); TNF-α(17 ± 9 pg/mL vs 152 ± 43 pg/mL,P = 0.013; IL-6(62 ± 18 pg/mL vs 281 ± 92 pg/mL); IL-10(40 ± 9 pg/mL vs 78 ± 10 pg/mL P = 0.03),and nitrite/nitrate(3.8 ± 0.9 μmol/L vs 10.2 ± 2.4 μmol/L,P = 0.025) when compared to the saline group.A significant reduction in liver mitochondrial dysfunction was observed in the diazoxide group compared to the saline group(P < 0.05).No differences in liver MDA content,serum creatinine,pulmonary vascular permeability and MPO activity were observed between groups.Twenty four hours after reperfusion the diazoxide group showed a reduction of AST(495 ± 78 U/L vs 978 ± 192 U/L,P = 0.032); ALT(335 ± 59 U/L vs 742 ± 182 U/L,P = 0.048),and TGF-β1(11 ± 1 ng/mL vs 17 ± 0.5 ng/mL,P = 0.004) serum levels when compared to the saline group.The control group did not present alterations when compared to the diazoxide and saline groups.CONCLUSION:Diazoxide maintains liver mitochondrial function,increases liver tolerance to ischemia/reperfusion injury,and reduces the systemic inflammatory response.These effects require further evaluation for using in a clinical setting. | Mateus Antunes Nogueira Ana Maria Mendona Coelho Sandra Nassa Sampietre Rosely Antunes Patzina Fabiano Pinheiro da Silva Luiz Augusto Carneiro D'Albuquerque Marcel Cerqueira Cesar Machado | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 3 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 4 | Allometric models for nondestructive leaf area estimation in coffee (Coffea Arabica and Coffea canephora)显示文摘 | Antunes W C PompeUi M F Carretero D M | 2008 | Ann Appl Biol2008，153，1： | 1 |
| 5 | Influence of through-thickness crack profile on plasticity induced crack closure显示文摘 | BRANCO R RODRIGUES D M ANTUNES F V | 2008 | Fatigue & Facture of Engineering Materials & Structures2008，31，2： | 1 |
| 6 | Effects of the antioxidants curcumin or Selenium on cisplatin induced nephrotoxicity and lipid peroxidatian in rats显示文摘 | Lusania M Greggi ANTUNES Joana D'ARC C | 2001 | Pharmacologieal Research2001，43，2： | 1 |
| 7 | Analysis of spatial interpolation for optimizing management of a salinized field cultivated with lettuce显示文摘 | Panagopoulos T Jesus J Antunes M D C | 2006 | European Journal of Agronomy2006，24，1： | 1 |
| 8 | A study on the mechanical behaviour of WC/Co hardmetals显示文摘 | FERREIRA J A M P1NA AMARAL M A ANTUNES F V COSTA J D M | 2009 | International Journal of Refractory Metals & Hard Materials2009，27，： | 1 |
| 9 | Erythema nodosum leprosum associated with minocycline显示文摘 | Travassos AR Antunes J Pacheco D | 2012 | Acta Dermatovenerol Alp Pannonica Adriat2012，21，2： | 1 |
| 10 | Morphologic and molecular features of hepatocellular adenoma with gadoxetic acid-enhanced MR imaging显示文摘 | Ba-Ssalamah A Antunes C Feier D | 2015 | Radiology2015，277，5： | 1 |
| 11 | Associations between nutritional markers and inflammation in hemodialysis patients显示文摘 | VANNINI F D ANTUNES A A CARAMORI J C | 2009 | Int Urol Nephrol2009，41，4： | 1 |
| 12 | Are metallothioneins equally good biomarkers of metal and oxidative stress显示文摘 | Figueira E Branco D Antunes S C | 2012 | Ecotoxicology and Environmental Safety2012，84，： | 1 |
| 13 | Palatable solutions during paradoxical sleep deprivation: reduction of hypothalamic-pituitary- adrenal axis activity and lack of effect on energy imbalance 显示文摘 | Suchecki D Antunes J Tufik S | 2003 | J Neuroendocrinology2003，15，： | 1 |
| 14 | Volterra integral approach to impulsive renewal systems: application to networked control 显示文摘 | ANTUNES D HESPANHA J P SILVESTRE C | 2012 | IEEE Transactions on Automatic Control2012，57，3： | 1 |
| 15 | Hepatitis B and HIV: prevalence, AIDS progression, response to highly active antiretroviral therapy and increased mortality in the EuroSIDA cohort显示文摘 | Deborah Konopnicki Amanda Mocroft S de Wit Francisco Antunes Bruno Ledergerber Christine Katlama K Zilmer Stefano Vella Ole Kirk Jens D Lundgren | 2005 | AIDS2005，，6： | 1 |
| 16 | ' Rocha' pear firmness predicted by a Vis/NIR segmented model显示文摘 | Cavaco A M Pinto P Antunes D M | 2009 | Postharvest Biology and Technology2009，51，3： | 1 |
| 17 | Fatigue behaviour and life prediction of lateral notched round bars under banding-torsiun loading显示文摘 | Branco R Costa J D Antunes F V | 2014 | Engineering Fracture Mechanics2014，119，1： | 1 |
| 18 | Remote identification of impact forces on loosely supported tubes: Part 1-basic theory and experiments 显示文摘 | Araujo M D Antunes J | 1998 | Journal of Sound and Vibration1998，215，5： | 1 |
| 19 | Palatable solutions during paradoxical sleep deprivation: reduction of hypothalamic-pituitary-adrenal axisactivity and lack of effect on energy imbalance 显示文摘 | Suchecki D Antunes J Tufik S | 2003 | Neurcendocrinol2003，15，9： | 1 |
| 20 | SHPA standards of practice for clinical pharmacy 显示文摘 | Michael D Antun B Margaret C | 2005 | Journal of Pharm Pract Research2005，35，2： | 1 |
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