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| 1 | Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients?显示文摘Chronic hepatitis B(CHB) remains a challenging global health problem, with nearly one million related deaths per year. Nucleos(t)ide analogue(NA) treatment suppresses viral replication but does not provide complete cure of the hepatitis B virus(HBV) infection. The accepted endpoint for therapy is the loss of hepatitis B surface antigen(HBs Ag), but this is hardly ever achieved. Therefore, indefinite treatment is usually required. Many different studies have evaluated NA therapy discontinuation after several years of NA treatment and before HBs Ag loss. The results have indicated that the majority of patients can remain off therapy, with some even reaching HBs Ag seroconversion. Fortunately, this strategy has proved to be safe, but it is essential to consider the risk of liver damage and other comorbidities and to ensure aclose follow-up of the candidates before considering this strategy. Unanswered questions remain, namely in which patients could this strategy be effective and what is the optimal time point at which to perform it. To solve this enigma, we should keep in mind that the outcome will ultimately depend on the equilibrium between HBV and the host's immune system. Viral parameters that have been described as good predictors of response in HBe Ag(+) cases, have proven useless in HBe Ag(-) ones. Since antiviral immunity plays an essential role in the control of HBV infection, we sought to review and explain potential immunological biomarkers to predict safe NA discontinuation in both groups. | Elia Moreno-Cubero Robert T Sánchez del Arco Julia Pena-Asensio Eduardo Sanz de Villalobos Joaquín Míquel Juan Ramón Larrubia | 2018 | World Journal of Gastroenterology2018，24，17： | 5 |
| 2 | A measurement method based on a modified version of the Chirplet transform for instantaneous frequency estimation显示文摘 | Angrisani L D' Arco M | 2002 | IEEE Trans Instruction and Measurement2002，51，4： | 1 |
| 3 | Test equipment for DAC's performance assessment: Design and characterization显示文摘 | A Baccigalupi M D' Arco A Liccardo M Vadursi | 2010 | IEEE Transactions on Instlumentation and Measurement2010，59，5： | 1 |
| 4 | Design of self-healing key distribution schemes显示文摘 | BLUNDO C D’ARCO P LISTO M | 2004 | Designs Codes and Cryptography2004，32，12： | 1 |
| 5 | Synthesis, characterization and catalytic behaviour of SAPO-11 obtained at low crystallization times and with low organic agent content显示文摘 | LOPEZ C M ESCOBAR V ARCOS M E NOBREGA L D YANEZ F GARACIA L V | 2008 | Catalysis Today2008，，： | 1 |
| 6 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 7 | Silicon incorporation in hydroxyapatite obtained by controlled crystallization显示文摘 | Arcos D Rodriguez Carvajal J Vallet Regi M | 2004 | Chem Mater2004，16，6： | 1 |
| 8 | Fludarabine and cytarabine as continuous sequential infusion for elderly patients with acute myeloid leukemia显示文摘 | Ferrara F D'Arco AM De Simone M | 2005 | Haematologica2005，90，6： | 1 |
| 9 | Delayed upregulation of ATP P2X3receptors of trigeminal sensory neurons by calcitonin gene-related peptide显示文摘 | Fabbretti E D’Arco M Fabbro A | 2006 | J Neurosci2006，26，23： | 1 |
| 10 | Feasible predictive criteria for reproductive performance of white shrimp Litopenaeus vannamei : egg quality and female physiological condition显示文摘 | Arcos F G Ibarra A M Palacios E | 2003 | Aquaculture2003，228，14： | 1 |
| 11 | Procalcitonin and C-reactive protein as markers of systemic inflanmmtory response syndrome severity in critically ill children显示文摘 | Rey C Los Arcos M Concha A | 2007 | Intensive Care Med2007，33，3： | 1 |
| 12 | Mesoporous ma- terials for drug delivery 显示文摘 | Vallet-Regi M Balas F Arcos D | 2007 | Angew Chem Int Ed2007，46，40： | 1 |
| 13 | Risk HLA -DQAI and PLA(2) R1 alleles in idiopathic membranous ne phropathy显示文摘 | Stanescu HC Arcos - Burgos M Medlar A | 2011 | N Engl J Med2011，364，7： | 1 |
| 14 | Vitiligo:complex segregation and linkage disequilibrium analyses with respect to microsatellite loci spanning the HLA显示文摘 | Arcos Burgos M Parodi E | 2002 | Human Gen2002，110，4： | 1 |
| 15 | Quantitative enzymatic production of 1,6-diacyl fruetofuranoses显示文摘 | Arcos J A Bernabe M Cristina O | 1998 | Enzyme and Microbial Technology1998，22，1： | 1 |
| 16 | Mesoporous materials for drug delivery 显示文摘 | VALLET-REGI M BALAS F ARCOS D | 2007 | Angew Chem Int Ed2007，46，40： | 1 |
| 17 | Vitiligo: complex segregation and linkage disequilibrium analyses with respect to microsatellite locispanning the HLA 显示文摘 | Arcos - Burgos M Parodi E | 2002 | Human Genetics2002，110，4： | 1 |
| 18 | Haemolymph metabolic variables in relation to eyestalk ablation and gonad development of Pa- cific white shrimp Litopenaeus vannamei Boone显示文摘 | Arcos G F Ibarra A M Vazquez Boucard C | 2003 | Aquaculture Research2003，34，9： | 1 |
| 19 | Echocardiographic quantification of myocardial function using tissue deformation imaging,a guide to image acquisition and analysis using tissue Doppler and speckle tracking显示文摘 | ARCO J T BART W L D B PAUL G M | 2007 | Cardiovasc Ultrasound2007，5，3： | 1 |
| 20 | Genetic parameter estimates for reproductive traits and egg composition in Pacific white shrimp Penaeus (Litopenaeus) vannamei显示文摘 | ARCOS F G RACOTTA I S IBARRA A M | 2004 | Aquaculture2004，236，： | 1 |
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