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| 1 | Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?显示文摘Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed by taxane and platinum-based chemotherapy. Newer therapies including limited targeted agents and intraperitoneal delivery of chemotherapeutic drugs have improved disease-free intervals, but failed to yield longlasting cures in most patients. Chemotherapeutic resistance, particularly in the recurrent setting, plagues the disease. Targeting the pathways and mechanisms behind the development of chemoresistance in ovarian cancer could lead to significant improvement in patient outcomes. In many malignancies, including blood and other solid tumors, there is a subgroup of tumor cells, separate from the bulk population, called cancer stem cells(CSCs). These CSCs are thought to be the cause of metastasis, recurrence and resistance. However, todate, ovarian CSCs have been difficult to identify, isolate, and target. It is felt by many investigators that finding a putative ovarian CSC and a chemotherapeutic agent to target it could be the key to a cure for this deadly disease. This review will focus on recent advances in this arena and discuss some of the controversies surrounding the concept. | Christen L Walters Haygood Rebecca C Arend J Michael Straughn Donald J Buchsbaum | 2014 | World Journal of Stem Cells2014，6，4： | 7 |
| 2 | Pseudophosphorylation of tau p rotein alters its ability for self-aggregation显示文摘 | Haase C Stieler J Arend TT | 2004 | J Neurochem2004，88，： | 1 |
| 3 | Oxidation transformation of organic compounds mediated by redox molecular sieves显示文摘 | ARENDS I W C E SHELDON R A WALLAU M SCHUCHARDT U | 1997 | Angew Chem Int Ed Engl1997，36，： | 1 |
| 4 | IL-1, IL-18, and IL-33 families of cytokines显示文摘 | Arend WP Palmer G Gabay C | 2008 | Immunol Rev2008，223，： | 1 |
| 5 | Cu( Ⅱ)-nitroxyl radi- cals as catalytic gaLactose oxidase mimics显示文摘 | Dijksman A Arends I W C E Sheldon R A | 2003 | Org Biomol Chem2003，1，18： | 1 |
| 6 | Classification of gastric carcinoma using the Goseki system provides prognostic information additional to TNM staging显示文摘 | Songun I van de Velde C J Arends J W | 1999 | Cancer1999，85，10： | 1 |
| 7 | Comparative spinal distribution and clearance kinetics of intratheeally administered morphine,fentanyl,alfentanil,and sufentanil显示文摘 | UMMENHOFER W C ARENDS R H SHEN D D | 2000 | Anesthesiology2000，92，3： | 1 |
| 8 | IL-1, IL-18, and IL-33 families of eytokines显示文摘 | Arend W P Palmer G Gabay C | 2008 | Immunol Rev2008，223，： | 1 |
| 9 | Advanced me thods in meta-analysis: multivariate approach and meta-regression显示文摘 | Van Houwelingen H C Arends L R Stijnen T | 2002 | Stat Med2002，21，4： | 1 |
| 10 | C-reactive protein: history and revival 显示文摘 | Hans C Arend E | 2002 | Eur J Int Med2002，，13： | 1 |
| 11 | Inhibition of Wnt/β-catenin pathway by niclosamide:a therapeutic target for ovarian cancer显示文摘 | AREND R C LONDONO JOSHI A I SAMANT RS | 2014 | Gynecol Oncol2014，134，1： | 1 |
| 12 | Predictive value for progression to tuberculosis by IGRA and TST in immigrant contacts 显示文摘 | Kik SV Franken WP Mensen M Cobelens FG Kamphorst M Arend SM Erkens C Gebhard A Borgdorff MW Verver S | 2010 | Eur Respir J2010，35，6： | 1 |
| 13 | IL-1,IL-18,and IL-33 families of cytokines显示文摘 | Arend WP Palmer G Gabay C | 2008 | Immunol Rev2008，223，： | 1 |
| 14 | Interleukin-1 receptor antagonist:role in biology显示文摘 | Arend W P Malyak M Guthridge C J | 1998 | Annu Rev Immunol1998，16，： | 1 |
| 15 | Green, cata-lytic oxidation of alcohols in water 显示文摘 | ten Brink G J Arends I W C E Sheldon R A | 2000 | Science2000，287，5458： | 1 |
| 16 | The Baeyer- Villiger reaction: New developments toward greener procedures显示文摘 | ten Brink G J Arends I W C E Sheldon R A | 2004 | Chemical Reviews2004，104，9： | 1 |
| 17 | C-reactive protein: history and revival显示文摘 | Hans C Abli J Arend E | 2002 | European Journal of Internal Medicine2002，，13： | 1 |
| 18 | Oxidative transformations of organic compounds mediated by redox molecular sieves显示文摘 | ARENDS I W C E SHELDON R A WALLAU M | 1997 | Angew Chem fat Ed Engl1997，36，11： | 1 |
| 19 | A GIS-based support tool for sustain- able spatial planning in metropolitan areas显示文摘 | Gerrit J C Arend L | 2007 | Landscape and Urban Planning2007，80，2： | 1 |
| 20 | Physiologic role of interleukin 1 receptor ant agonist显示文摘 | Arend W P Gabay C | 2000 | Arthritis Res2000，2，4： | 1 |
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