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| 1 | Comparison of the effects of bevacizumab and ranibizumab injection on corneal angiogenesis in an alkali burn induced model显示文摘·AIM:To investigate the effects of bevacizumab and ranibizumab on corneal neovascularization in an alkali burn-induced model of corneal angiogenesis. ·METHODS:Fifteen Wistar-Albino rats were divided randomly into 3 groups after chemical cauterization of the cornea. The first group received a single dose of 0.1mL saline solution as a control group whereas second and third groups received a single dose of 2.5mg bevacizumab or 1mg ranibizumab by subconjunctival injection, respectively. After three weeks, the rat corneas were evaluated by biomicroscopy and corneal photographs were taken. The percentage of neovascularization area, length of the longest new vessel, corneal oedema and corneal opacity scores were assessed. ·RESULTS:The analysis of digital photographs showed that the percentage of neovascularization area to the total corneal area, the length of the longest new vessel, corneal oedema and opacity scores were significantly lower in both study groups compared to the control group (P <0.05). Additionally, the percentage of corneal neovascularization area, the length of the longest new vessel and corneal opacity score were less with bevacizumab than ranibizumab. ·CONCLUSION:Subconjunctival bevacizumab and ranibizumab treatments may be effective methods in reducing corneal neovascularization. Furthermore, bevacizumab is more effective than ranibizumab in the inhibition of corneal neovascularization. | Ayhan Dursun Mustafa Kemal Arici Feyza Dursun Ayse Vural Ozec Mustafa Ilker Toker Haydar Erdogan Aysen Topalkara | 2012 | International Journal of Ophthalmology(English edition)2012，5，4： | 10 |
| 2 | Gastroesophageal reflux in asymptomatic obese subjects:An esophageal impedance-pH study显示文摘AIM:To investigate the relationship between reflux and body mass index(BMI) in the asymptomatic obese population using the impedance-p H technique.METHODS:Gastroesophageal reflux is frequent in the obese population.However,the relationship between acid reflux and BMI in asymptomatic obese people is unclear.Forty-six obese(BMI > 25 kg/m2) people were enrolled in this prospective study.We evaluated the demographic findings and 24-h impedance p H values of the whole group.Gas,acid(p H < 4),weak acid(p H = 4-7) and weak alkaline(p H ≥ 7) reflux parameters were analyzed.RESULTS:The mean age of patients was 49.47±12.24 years,and half of them were men.The mean BMI was 30.64±3.95 kg/m2(25.14-45.58 kg/m2).BMI of 23 was over 30 kg/m2.Seventeen patients had a comorbidity(hypertension,diabetes mellitus,or ischemic heart disease).Endoscopic examination revealed esophagitis in 13 of the 28 subjects(10Grade A,3 Grade B).The subjects were divided into two groups according to BMI(<30 and>30 kg/m2).Demographic and endoscopic findings,and impedance results were similar in these two groups.However,there was a positive correlation between BMI and total and supine p H<4 episodes(P=0.002,r=0.414;P=0.000,r=0.542),p H<4 reflux time(P=0.015,r=0.319;P=0.003,r=0.403),and De Meester score(P=0.012,r=0.333).CONCLUSION:Acid reflux is correlated with BMI in asymptomatic obese individuals. | Filiz Akyüz Ahmet Uyanikoglu Fatih Ermis Serpil Arici ümit Akyüz Divison of Gastroenterology Department of Internal Medicine Faculty of Medicine Yeditepe University Bülent Baran Binnur Pinarbasi Nurdan Gul | 2015 | World Journal of Gastroenterology2015，21，10： | 3 |
| 3 | Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma显示文摘AIM: To investigate the oxidative stress status of the aqueous humor and serum of patients with pseudoexfoliation(PEX) syndrome and pseudoexfoliative glaucoma(PEG) and to measure paraoxonase(PON) and arylesterase(ARE) levels.·METHODS: A total of 78 patients were enrolled in the study, with 26 patients in each separate group. The patients were divided into three groups: the first group entailed PEX syndrome patients, while the second group consisted of patients with PEG and the third group involved patients with no additional systemic diseases,other than the diagnosis of cataract as control. Total oxidative stress(TOS), total antioxidant capacity(TAC),PON, and ARE levels in aqueous humor and serum were measured.·RESULTS: TAC, PON and arylesterase levels in aqueous humor and serum of the PEX syndrome and PEG patients were significantly decreased compared with control group(P <0.05). TOS values were higher in patients with PEX syndrome and PEG than controls(P <0.05). TAC, PON and ARE levels of aqueous humor did not differ significantly between the PEX syndrome and PEG groups·CONCLUSION: These findings are potentially of significance and add to the growing body of evidence for oxidative stress in PEX syndrome and PEG. Decreased antioxidant defense and increased oxidative stress system may play an important role in the pathogenesis of PEX syndrome and PEG. | Feyza Dursun Ayse Vural Ozec Huseyin Aydin Aysen Topalkara Ayhan Dursun Mustafa Ilker Toker Haydar Erdogan Mustafa Kemal Arici | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 2 |
| 4 | RNA interference against urokinase in hepatocellular carcinoma xenografts in nude mice显示文摘 | SALVI A ARICI B ALGHISI A | 2007 | Tumour Biol2007，28，： | 1 |
| 5 | Ketamine versus propofol for strabismus surgery in children显示文摘 | Mizrak A Erbagci I Arici T | 2010 | Clin Ophthalmol2010，4，： | 1 |
| 6 | Pathogenesis of endometriosis显示文摘 | Oral E Arici A | 1997 | Obstet Gynecol Cli North Am1997，24，： | 1 |
| 7 | Comparison of in- trauterine insemination with timed intercourse in superovu lated cycles with gonadotropins: a meta-analysis显示文摘 | Zeyneloglu HB Arici A Olive DL | 1998 | Fertil Steril1998，69，3： | 1 |
| 8 | Medical management of endometriosis associated pain显示文摘 | Mahutte MG Arici A | 2003 | Obstet Gynecol Clin North Am2003，30，1： | 1 |
| 9 | Comparison of intrauterine insemination with timed in tercourse in superovulated cycles with gonadotropins:ametaanalysis显示文摘 | Ieyneloglu HB Arici A Olive PI | 1998 | Fertil Steril1998，69，： | 1 |
| 10 | Medical management of endometriosis - associated pain显示文摘 | Mahutte NG Arici A | 2003 | Obstet Gynecol Clin N Am2003，30，： | 1 |
| 11 | Endometriosis and infertility:epidemiology and evidence based treatments显示文摘 | Sebiha Ozkan William Murk Aydin Arici | 2008 | Annals of the New York Academy of Sciences2008，1127，： | 1 |
| 12 | Expression of retinoblastoma and cyclin D1 in gastric carcinoma 显示文摘 | Arici DS Tuncer E Ozer H | 2009 | Neoplasma2009，56，1： | 1 |
| 13 | Evidence - based diagnosis and management of tubal factor infertility显示文摘 | Kodaman P H Arici A Seli E | 2004 | Curr Opin Ob- stet Gynecol2004，16，3： | 1 |
| 14 | Intra-uterine adhesions and fertility outcome:how to optimize success显示文摘 | Kodaman PH Arici A | 2007 | Curr Opin Obstet Gynecol2007，19，3： | 1 |
| 15 | Effect of latanoprost/timolol and dorzolamide/tiomolol on intraocular pressure after phacoemulsification surgery显示文摘·AIM:To evalaute the effect of fixed-combination latanoprost 0.005%/timolol maleate 0.5% and dorzolamide hydrochloride 2%/timolol maleate 0.5% on postoperative intraocular pressure after phacoemulsification cataract surgery.·METHODS:This study is a prospective,randomized,double-masked and placebo-controlled.The study included 90 eyes of 90 patients which were scheduled to have phacoemulsification surgery.Patients were randomly assigned preoperatively to 1 of 3 groups (30 eyes of 30 patients).Two hour before surgery,the patients received one drop latanoprost/timolol (group 1),dorzolamide/timolol (group 2) and placebo (group 3,control group).The IOPs were measured at preoperative and postoperative 4,8,and 24 hours.·RESULTS:The preoperative mean intraocular pressure was not statistically significant between both drug groups and control group.In group 1 and 2,the postoperative mean IOP [group1:(14.03?à3.15)mmHg and group 2:(14.16?à4.43)mmHg] at 24 hours were significantly lower than the control group [(16.93?à3.70)mmHg,(P <0.05)].In addition,the postoperative mean IOP of group 1 [(14.90±3.69)mmHg] at 8 hours was significantly lower than the control group [(17.70?à3.89)mmHg,(P <0.05)],but there was no significant difference between group 2 [(16.16?à5.23)mmHg] and control group at 8 hours (P >0.05).·CONCLUSION:When compared with placebo,the use of preoperative fixed combination of latanoprost/timolol and dorzolamide/timolol is an effective method for preventing intraocular pressure elevation in 24 hours after phacoemulsification surgery,but did not completely prevent IOP spikes.· | Haydar Erdogan Ayse Vural Ozec Cengiz Caner Mustafa Ilker Toker Mustafa Kemal Arici Aysen Topalkara | 2011 | International Journal of Ophthalmology(English edition)2011，4，2： | 1 |
| 16 | Interactions of cytokines, growth factors, and the extracellular matrix in the cellular biology of uterine lelomyomata 显示文摘 | Sozen I Arici A | 2002 | Fertil Steril2002，78，1： | 1 |
| 17 | Hyperinsulinism and its interaction with hyperandrogenism in polycystic ovary syndrome显示文摘 | Sozen I Arici A | 2000 | Obstet Gynecol2000，56，5： | 1 |
| 18 | Chemokines and human reproduction 显示文摘 | Garcia- Velasco JA Arici A | 1999 | Fertil Steril1999，71，6： | 1 |
| 19 | Uterine chemokines in reproductive physiology and pathology显示文摘 | Kayisli U A Mahutte N G Arici A | 2002 | Am J Reprod Immunol2002，47，4： | 1 |
| 20 | Immunology of endometriosis显示文摘 | Ululzus M Arici A | 2005 | Minerva Ginecol2005，57，： | 1 |
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