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| 1 | Nasopharyngeal carcinoma in Indonesia:epidemiology,incidence,signs,and symptoms at presentation显示文摘Among all head and neck (H&N) cancers,nasopharyngeal carcinoma (NPC) represents a distinct entity regarding epidemiology,clinical presentation,biological markers,carcinogenic risk factors,and prognostic factors.NPC is endemic in certain regions of the world,especially in Southeast Asia,and has a poor prognosis.In Indonesia,the recorded mean prevalence is 6.2/100 000,with 13 000 yearly new NPC cases,but otherwise little is documented on NPC in Indonesia.Here,we report on a group of 1121 NPC patients diagnosed and treated at Dr.Cipto Mangunkusumo Hospital,Jakarta,Indonesia between 1996 and 2005.We studied NPC incidence among all H&N cancer cases (n=6000) observed in that period,focusing on age and gender distribution,the ethnic background of patients,and the disease etiology.We also analyzed most prevalent signs and symptoms and staging of NPC patients at first presentation.In this study population,NPC was the most frequent H&N cancer (28.4%),with a male-to-female ratio of 2.4,and was endemic in the Javanese population.Interestingly,NPC appeared to affect patients at a relatively young age (20% juvenile cases) without a bimodal age distribution.Mostly,NPC initiated in the fossa of Rosenmuller and spreaded intracranially or locally as a mass in the head.Occasionally,NPC developed at the submucosal level spreading outside the anatomic limits of the nasopharynx.At presentation,NPC associated with hearing problems,serous otitis media,tinnitus,nasal obstruction,anosmia,bleeding,difficulty in swallowing and dysphonia,and even eye symptoms with diplopia and pain.The initial diagnosis is difficult to make because early signs and symptoms of NPC are not specific to the disease.Early-age Epstein-Barr virus (EBV) infection combined with frequent exposure to environmental carcinogenic co-factors is suggested to cause NPC development.Undifferentiated NPC is the most frequent histological type and is closely associated with EBV.Expression of the EBV-encoded latent membrane protein 1(LMP1) oncogene in biopsy material was compared between NPC patients of <30 years old and those of ≥30 years old,matched for sex and tumor stage.Higher LMP1 expression in patients of <30 years old was observed,which was related to more locoregional progressivity.Increased medical awareness of prevailing early stage signs and symptoms coupled to use of EBV-related diagnostic tumor markers may lead to down-staging and timely treatment to improve survival of patients with this aggressive disease. | Marlinda Adham Antonius N.Kurniawan Arina Ika Muhtadi Averdi Roezin Bambang Hermani Soehartati Gondhowiardjo I Bing Tan Jaap M.Middeldorp | 2012 | Chinese Journal of Cancer2012，31，4： | 22 |
| 2 | Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. | Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 3 | “Stop Ne(c)king around”: How interactomics contributes to functionally characterize Nek family kinases显示文摘Aside from Polo and Aurora, a third but less studied kinase family involved in mitosis regulation is the never in mitosis-gene A(NIMA)-related kinases(Neks). The founding member of this family is the sole member NIMA of Aspergillus nidulans, which is crucial for the initiation of mitosis in that organism. All 11 human Neks have been functionally assigned to one of the three core functions established for this family in mammals:(1) centrioles/mitosis;(2) primary ciliary function/ciliopathies; and(3) DNA damage response(DDR). Recent findings, especially on Nek 1 and 8, showed however, that several Neks participate in parallel in at least two of these contexts: primary ciliary function and DDR. In the core section of this in-depth review, we report the current detailed functional knowledge on each of the 11 Neks. In the discussion, we return to the cross-connections among Neks and point out how our and other groups' functional and interactomics studies revealed that most Neks interact with protein partners associated with two if not all three of the functional contexts. We then raise the hypothesis that Neks may be the connecting regulatory elements that allow the cell to fine tune and synchronize the cellular events associated with these three core functions. The new and exciting findings on the Nek family open new perspectives and should allow the Neks to finally claim the attention they deserve in the field of kinases and cell cycle biology. | Gabriela Vaz Meirelles Arina Marina Perez Edmárcia Elisa de Souza Ferna Luisa Basei Priscila Ferreira Papa Talita Diniz Melo Hanchuk Vanessa Bomfim Cardoso Jrg Kobarg | 2014 | World Journal of Biological Chemistry2014，5，2： | 2 |
| 4 | 基于纤毛鹅观草特异的卫星重复序列开发寡核苷酸探针显示文摘[目的]本文旨在开发纤毛鹅观草特异的寡核苷酸(oligonucleotide,oligo)探针,进一步完善纤毛鹅观草染色体鉴定技术。[方法]利用前期选育的普通小麦-纤毛鹅观草异附加系DA2S^(c)L和DA6S^(c),通过流式分拣和基因组二代测序获得纤毛鹅观草染色体6S^(c)和染色体臂2S^(c)长臂的基因组序列,利用Repeatexplorer2/TAREAN软件从中鉴定出卫星重复序列并设计成oligo探针,通过荧光原位杂交(fluorescence in situ hybridization,FISH)分析所开发oligo探针的应用价值。[结果]从6S^(c)和2S^(c)L基因组序列中共鉴定出11个卫星重复序列并开发成11个oligo探针,oligo-FISH结果表明,其中6个探针可以在纤毛鹅观草染色体上产生明显杂交信号,而在小麦染色体上未产生明显杂交信号,可用于特异鉴定小麦背景中的纤毛鹅观草染色体或片段。对1套普通小麦-纤毛鹅观草异附加系oligo-FISH分析发现,oligo-2S^(c)L^(-1)63和oligo-6S^(c)-111仅在S^(c)基因组染色体上产生明显信号,可作为纤毛鹅观草S^(c)组特异探针;将oligo-2S^(c)L-161和oligo-2S^(c)L-163组合,对1整套二体异附加系进行双色oligo-FISH,构建了纤毛鹅观草染色体的oligo-FISH核型。[结论]本研究提供了纤毛鹅观草重复序列组成的初步信息,开发的探针能特异鉴定纤毛鹅观草染色体,阐明纤毛鹅观草2个基因组的来源和分化,对推动纤毛鹅观草优异基因的转移和利用有重要意义。 | 程梦豪 Miroslava Karafiatova 孙昊杰 Kate Arina Holušva Jaroslav Dolezel 宋新颖 王海燕 王秀娥 | 2022 | 南京农业大学学报2022，45，3： | 2 |
| 5 | Novel metal complexes of boronated chlorin c6 for photodynamic therapy显示文摘 | Valentina A O Arina N Savchenko | 2009 | Journal of Organometallic Chemistry2009，694，11： | 1 |
| 6 | Use of gene therapy in a subcutaneous murine model of lung cancer 显示文摘 | Rodrigo Garzon M Tirapu Femondez de la Cuesta I Arina Iraeta A | 2006 | Arch Bronconeumol2006，42，10： | 1 |
| 7 | An analysis of de- centralized collection and processing of end of life prod- ucts显示文摘 | Karakayali I Arinas H Akcali E | 2007 | Journal of Operations Management2007，25，6： | 1 |
| 8 | Use of gcne therapy in subcutaneous murine model of lung cancer 显示文摘 | Rodrigo Garzon M Tirapu Fernondez de la Cuesta 1 Arina Iraeta A | 2006 | Areh Bronconeumo12006，42，10： | 1 |
| 9 | Myeloid-derived suppressor cell impact on endogenous and adoptively transferred T cells 显示文摘 | Arina A and Bronte V | 2015 | CUlT Opin Immuno12015，33，： | 1 |
| 10 | Densely granulated murine NK cells eradicate large solid tumors 显示文摘 | Liu RB Engels B Arina A | 2012 | Cancer Res2012，72，8： | 1 |
| 11 | Tissue-Specific Expression of a Gene Encoding a Cell Wall Localized Lipid Transfer Protein from Arabidopsis 显示文摘 | S Thoma Ursula Hecht Arina Kippers | 1994 | Plant Physiology1994，105，： | 1 |
| 12 | Modulation of apoptosis by early human papillomavirus proteins in cervical cancer显示文摘 | Lagunas-Martínez A Madrid-M arina V Gariglio P | 2010 | Biochim Biophys Acta2010，，： | 1 |
| 13 | Efcts of dopamine antagonists with different receptor blockade profiles on morphine - induced place preference in male mice 显示文摘 | Manzanedo C Aguilar MA Rodriguez - Arinas M | 2001 | Behav Brain Res2001，121，12： | 1 |
| 14 | Progression of cancer from indolent to aggressive despite antigen retention and increased expression of interferon-gamma inducible genes显示文摘 | Wu TH Schreiber K Arina A | 2011 | Cancer Immun2011，30，11： | 1 |
| 15 | Effect of early inten-sive blood pressure-lowering treatment on the growth of hema-toma and perihematomal edema in acute intracerebral hemor-rhage: the Intensive Blood Pressure Reduction in Acute Cere-bral Hemorrhage Trial (INTERACT) 显示文摘 | Anderson CS Huang Y Arina H | 2010 | Stoke2010，41，2： | 1 |
| 16 | Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells显示文摘 | ARINA A MURILLO O DUBROT J | 2008 | Gene Ther2008，15，7： | 1 |
| 17 | The Information Content of Earnings Announcements in Denmark 显示文摘 | C arina Sponhohz | 2008 | International Journal of Managerial Finance2008，4，1： | 1 |
| 18 | Bactericidal action of lysozyme attached with various sizes of hydrophobic peptides to the C-terminal using genetic modification 显示文摘 | Hideyuki Arina Hisham 1Kadwan lbrahin Takeshi Kinoshita | 1997 | FEBS Letters1997，415，： | 1 |
| 19 | Enzym mimicry by the antiidiotypic antibody approach 显示文摘 | Alexander VK Arina VK Elen SA | 2000 | Pro Natl Acad Sci USA2000，97，13： | 1 |
| 20 | Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer显示文摘 | ARINA A MURILLO O DUBROT J | 2007 | Expert Opin Biol Ther2007，7，5： | 1 |
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