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56篇 您的检索式：作者名="Armeanu"

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	题名	作者	年代	出处	被引量
1	Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine.	Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o\|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer	2005	World Journal of Gastroenterology2005，11，44：	2
2	The activity of γδ T cells against paediatric liver tumour cells and spheroids in cell culture显示文摘	Alexander Hoh Alexander Dewerth Fabian Vogt Julia Wenz Patrick A. Baeuerle Steven W. Warmann Joerg Fuchs Sorin Armeanu‐Ebinger	2012	Liver Int2012，，1：	1
3	Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357显示文摘	Armeanu S Pathil A Venturelli S	2005	J Hepatol2005，42，：	1
4	Natural killer cell-media ted lysis of hepatoma cells via specific induction of NKG2D lig- ands by the histone deacetylase inhibitor sodium valproate显示文摘	Armeanu S Bitzer M Lauer UM	2005	Cancer Res2005，65，14：	1
5	Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357 显示文摘	Armeanu S Pathil A Venturelli S	2005	J Hepatol2005，42，2：	1
6	N-cadherin is developmentally regulated and functionally involved in early hematopoietic cell differentiation显示文摘	Puch S Armeanu S Kibler C	2001	J Cell Sci2001，114，8：	1
7	Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357 显示文摘	Armeanu S Pathil A Venturelli S	2005	J Hepatol2005，42，：	1
8	Successful es- tablishment of an orthotopic hepatoblastoma in vivo model in NOD/ LtSz- scid IL2Rγ null mice显示文摘	Ellerkamp V Armeanu - Ebinger S Wenz J	2011	PLoS One2011，6，23：	1
9	About ambivalent groups显示文摘	Armeanu I	1996	Annaels mathematiqes Blaise Pascal1996，3，：	1
10	Direct and natural killer cell-mediated antitumor effects of lowdose bortezomib in hepatocellular carcinoma显示文摘	ARMEANU S KRUSCH M 8ALTZ K M	2008	Clin CancerRes2008，14，11：	1
11	Adenovirus-media- ted cytosine deaminase/5-fluoroeytosine suicide gene therapy of human hepatoblastoma in vitro 显示文摘	Warmann SW Armeanu S Heigoldt H	2009	Pediatr Blood Cancer2009，53，2：	1
12	Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357显示文摘	Armeanu S Pathil A Venturelli S	2005	J Hepatol2005，42，2：	1
13	Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone descetylase inhibitor sodium valproate显示文摘	Armeanu s Bitzer M Lauer UM	2005	Cancer Res2005，65，14：	1
14	Direct and natural killer cell - mediated antitumor effects of low - dose bortezomib in hepa- tocellular carcinoma显示文摘	Armeanu S Kruseh M Baltz KM	2008	Clin Cancer Res2008，14，11：	1
15	Epigenetic combination therapy as a tumor-selective treatment approach for hepatocellular carcinoma显示文摘	Venturelli S Armeanu S Pathil A	2007	Cancer2007，109，10：	1
16	N-cadherin is developmentally regulated and functionally involved in early hematopoietic cell differentiation显示文摘	Puch S Armeanu S Kibler C	2001	J Cell Sci2001，114，8：	1
17	Direct and natural killer cell-mediated antitumor effects of low-dose bortezomib in hepatocellular carcinoma显示文摘	ARMEANU S KRUSCH M BALTZ K M	2008	Clin Cancer Res2008，14，11：	1
18	Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate显示文摘	ARMEANU S BITZER M LAUER U M	2005	Cancer Res2005，65，14：	1
19	Apoptosis on hepatoma cells but not on primary hepatoeytes by histone deaeetylase inhibitors valproate and ITF2357显示文摘	Armeanu S Pathil A Venturelli S	2005	J Hepatol2005，42，2：	1
20	Natural killer cell -mediatedlysis of hepatoma cells via specific induction of NKG2D ligands by thehistone deacetylase inhibitor sodium valproate显示文摘	Armeanu S Bitzer M Lauer UM	2005	Cancer Res2005，65，14：	1

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