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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Interleukin 10 reduces the severity of acute pancreatitis in rat显示文摘 | Rongione AJ Kusske AM Ashley SW | 1997 | Gastroenterology1997，112，3： | 1 |
| 3 | Interleukin-10 prevents early eytokine release in severe intraabdominal infection and sepsis显示文摘 | Rongione AJ Kusske AM Ashley SW | 1997 | J Sug Res1997，70，： | 1 |
| 4 | Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice显示文摘 | Kusske AM Rongione AJ Ashley SW | | 0，，： | 1 |
| 5 | Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice显示文摘 | Kusske AM Rongione AJ Ashley SW | | 0，，： | 1 |
| 6 | Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice显示文摘 | Kusske AM Rongione AJ Ashley SW | 1996 | Surgery1996，120，2： | 1 |
| 7 | Wnt signaling in polyposis patients显示文摘 | Caldwell GM Jones CE Ashley adenomas of familial adenomatous AM | 2010 | Br JCancer2010，103，6： | 1 |
| 8 | Interleukin 10 reduces the severity of acute pancreatitis in rat 显示文摘 | Rongione AJ Kusske AM Ashley SW | 1997 | Gastroenterology1997，112，3： | 1 |
| 9 | Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin显示文摘 | Eileen M. Moore Alastair G. Mander David Ames Mark A. Kotowicz Ross P. Carne Henry Brodaty Michael Woodward Karyn Boundy Kathryn A. Ellis Ashley I. Bush Noel G. Faux Ralph Martins Cassandra Szoeke Christopher Rowe David A. Watters | 2013 | Diabetes Care2013，，10： | 1 |
| 10 | Intedeukin-10 prevents death in lethal necrotizing pancreatitis in mice显示文摘 | Kusske AM Rongione AJ Ashley SW | 1996 | Surgery1996，120，2： | 1 |
| 11 | Quantitative detection of trichloroacetic acid in human urine using isotope dilution HPLC electrospray ionization tandem mass spectrometry 显示文摘 | Kuklenyik Z Ashley DL Calafat AM | 2002 | Analytical Chemistry2002，74，： | 1 |
| 12 | lnterleukin - 10 prevents death in lethal neerosising pancreatitis in mice 显示文摘 | Kusser AM Rongione AJ Ashley SW | 1999 | Surgery1999，120，： | 1 |
| 13 | In terleukin-10 prevents death in lethal necosizing pancreatitis in mice 显示文摘 | Kusser AM Rongione A J Ashley SW | 1996 | Surgery1996，120，11： | 1 |
| 14 | Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice 显示文摘 | Kusske AM Rongione A J Ashley SW | 1996 | Surgery1996，120，2： | 1 |
| 15 | Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice 显示文摘 | Kusske AM Rongione AJ Ashley SW | 1996 | Surgery1996，120，2： | 1 |
| 16 | Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice显示文摘 | Kusske AM Rongione AJ Ashley SW | 1996 | Surgery1996，120，2： | 1 |
| 17 | Interleukin 10 reduces the severity of acute pancreatitis in rat显示文摘 | Rongione A J Kusske AM Ashley SW | 1997 | Gastroenterology1997，112，3： | 1 |
| 18 | Interleukin-10 prevents death in lethal necrotizing pacreatitis in mice显示文摘 | Kusske AM Rongione AJ Ashley SW | 1996 | Surgery1996，120，2： | 1 |
| 19 | Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice 显示文摘 | Kusske AM Rongione AJ Ashley SW | 1996 | Surgery1996，120，2： | 1 |
| 20 | Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice显示文摘 | Kusske AM Rongione AJ Ashley SW | 1996 | Surgery1996，120，2： | 1 |
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