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| 1 | Perioperative chemotherapy for resectable gastric cancer:MAGIC and beyond显示文摘Over the last 15 years, there have been major advances in the multimodal treatment of gastric cancer, in large part due to several phase Ⅲ studies showing the treatment benefits of neoadjuvant and adjuvantchemotherapy and chemoradiation protocols. The objective of this editorial is to review the current highlevel evidence supporting the use of chemotherapy, chemoradiation and anti-HER2 agents in both the neoadjuvant and adjuvant settings, as well as to provide a clinical framework for use of this data based on our own institutional protocol for gastric cancer. Major studies reviewed include the SWOG/INT 0116, Medical Research Council Adjuvant Gastric Infusional Chemotherapy(MAGIC), CLASSIC, ACTS-GC, Adjuvant Chemoradiation Therapy in Stomach Cancer(ARTIST) and Trastuzumab for Gastric Cancer trials. Although these studies have demonstrated that multiple approaches in terms of the timing and therapy for gastric cancer are effective, no standard of care is widely accepted and questions regarding the optimal timing of chemotherapy, the benefit of radiotherapy, the minimum required extent of lymphadenectomy and optimal chemotherapy regimen still exist. Protocols from the upcoming ARTIST Ⅱ, CRITICS, TOPGEAR, Neo-AEGIS and MAGIC-B studies are outlined, and results from these studies will provide critical information regarding optimal timing and treatment regimen. Additionally, the future directions of gastric cancer research predicated on molecular profiling and tailored therapies based on targetable genetic alterations in individual patient's tumors are addressed. | Audrey H Choi Joseph Kim Joseph Chao | 2015 | World Journal of Gastroenterology2015，21，24： | 21 |
| 2 | Colon adenoma features and their impact on risk of future advanced adenomas and colorectal cancer显示文摘AIM To review the evidence on the association between specific colon adenoma features and the risk of future colonic neoplasia [adenomas and colorectal cancer(CRC)]. METHODS We performed a literature search using the National Library of Medicine through Pub Med from 1/1/2003 to 5/30/2015. Specific Medical Subject Headings terms(colon, colon polyps, adenomatous polyps, epidemiology, natural history, growth, cancer screening, colonoscopy, CRC) were used in conjunction with subject headings/key words(surveillance, adenoma surveillance, polypectomy surveillance, and serrated adenoma). We defined nonadvanced adenomas as 1-2 adenomas each < 10 mm in size and advanced adenomas as any adenoma ≥ 10 mm size or with > 25% villous histology or high-grade dysplasia. A combined endpoint of advanced neoplasia included advanced adenomas and invasive CRC.RESULTS Our search strategy identified 592 candidate articlesof which 8 met inclusion criteria and were relevant for assessment of histology(low grade vs high grade dysplasia, villous features) and adenoma size. Six of these studies met the accepted quality indicator threshold for overall adenoma detection rate > 25% among study patients. We found 254 articles of which 7 met inclusion criteria for the evaluation of multiple adenomas. Lastly, our search revealed 222 candidate articles of which 6 met inclusion criteria for evaluation of serrated polyps. Our review found that villous features, high grade dysplasia, larger adenoma size, and having ≥ 3 adenomas at baseline are associated with an increased risk of future colonic neoplasia in some but not all studies. Serrated polyps in the proximal colon are associated with an increased risk of future colonic neoplasia, comparable to having a baseline advanced adenoma.CONCLUSION Data on adenoma features and risk of future adenomas and CRC are compelling yet modest in absolute effect size. Future research should refine this risk stratification. | Audrey H Calderwood Karen E Lasser Hemant K Roy | 2016 | World Journal of Gastrointestinal Oncology2016，8，12： | 5 |
| 3 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | The Lancet . 2011 (9791)2011，，： | 3 |
| 4 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | The Lancet2011，，9791： | 3 |
| 5 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | The Lancet2011，，9791： | 2 |
| 6 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | 2011 (9791)2011，，9791： | 2 |
| 7 | Noninvasive pulse waveform analysis in clinical trials: Similarity of two methods for calculating aortic systolic pressure显示文摘 | AUDREY A KOZO H SONJA H | 2007 | American Journal of Hypertension2007，20，8： | 1 |
| 8 | A paternity case with three genetic incompatibilities between father and child due to maternal uniparental disomy 21 and a mutation at the Y chromosome显示文摘 | Audrey ML Jurgen H Henke L | 2009 | Forensic Sci Int Genet2009，3，2： | 1 |
| 9 | Pacitaxel and platinum chemotherapy for MMMTs of the ovary 显示文摘 | Audrey G Ganul H | 2002 | Gynecol Oncol2002，85，： | 1 |
| 10 | Antibody biosimilars: Fears or opportunities 显示文摘 | AUDREY G M DAGUET A WATIER H | 2014 | Landes Bioscience2014，6，4： | 1 |
| 11 | Dietary ni- trate and nitrite modulate blood and organ nitrite and the cellular ischemic stress response 显示文摘 | Nicolaas J H Raat Audrey C Noguchi | 2009 | Free Radical Biolo- gy and Medicine2009，47，5： | 1 |
| 12 | Benefits from angiotensin-eonver- ting enzyme inhibitor beyond blood pressure lowering': beyond blood-pressure or beyond the brachial artery 显示文摘 | Kozo H Charalambes V Audrey A | 2005 | J Hypertens2005，23，5： | 1 |
| 13 | The enable right vertricalar circulatory suport systom for bcating heast cornary artery bupase Groft surgery 显示文摘 | Gijs G Andre L Dekker Frederik H Vander-veen Keses B Prenger Audrey A Cramer S Jos G Davidshoshan I | 1999 | Ann Thorac Surg1999，68，： | 1 |
| 14 | Pancreatic cancer显示文摘 | Audrey Vincent Joseph Herman Rich Schulick Ralph H Hruban Michael Goggins | 2011 | The Lancet2011，，9791： | 1 |
| 15 | Procedural justice in entrepreneur- investor relations 显示文摘 | Sapienza H J Audrey K M | 1996 | Academy of Management Journal1996，39，3： | 1 |
| 16 | Procedural justice in entrepreneur investor relations 显示文摘 | Sapienza H J Audrey KM | 1996 | Academy of Management Journal1996，39，3： | 1 |
| 17 | Competitive allele specific TaqMan PCR for KRAS , BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples显示文摘 | Audrey Didelot Delphine Le Corre Armelle Luscan Aurélie Cazes Karine Pallier Jean-Fran?ois Emile Pierre Laurent-Puig Hélène Blons | 2012 | Experimental and Molecular Pathology2012，，3： | 1 |
| 18 | Geometric model for softwood transverse thermal conductivity显示文摘 | GU H M AUDREY Z S | 2005 | Wood and Fiber Science2005，37，4： | 1 |
| 19 | HPV genotype distribution according to severity of cervical neoplasia using the digene HPV genotyping LQ test显示文摘 | Philippe H Maria L ML Audrey R | | 0，，06： | 1 |
| 20 | Procedural justice in entrepreneur-investor relations 显示文摘 | SAPIENZA H J AUDREY KM | 1996 | Academy of Management Journal1996，39，3： | 1 |
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