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| 1 | Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation显示文摘The cysteine protease caspase-1(Casp-1)contributes to innate immunity through the assembly of NLRP3,NLRC4,AIM2,and NLRP6 inflammasomes.Here we ask whether caspase-1 activation plays a regulatory role in house dust mite(HDM)-induced experimental allergic airway inflammation.We report enhanced airway inflammation in caspase-1-deficient mice exposed toHDMwith a marked eosinophil recruitment,increased expression of IL-4,IL-5,IL-13,aswell as full-length and bioactive IL-33.Furthermore,mice deficient for NLRP3 failed to control eosinophil influx in the airways and displayed augmented Th2 cytokine and chemokine levels,suggesting that the NLPR3 inflammasome complex controls HDM-induced inflammation.IL-33 neutralization by administration of soluble ST2 receptor inhibited the enhanced allergic inflammation,while administration of recombinant IL-33 during challenge phase enhanced allergic inflammation in caspase-1-deficient mice.Therefore,we show that caspase-1,NLRP3,and ASC,but not NLRC4,contribute to the upregulation of allergic lung inflammation.Moreover,we cannot exclude an effect of caspase-11,because caspase-1-deficient mice are deficient for both caspases.Mechanistically,absence of caspase-1 is associated with increased expression of IL-33,uric acid,and spleen tyrosine kinase(Syk)production.This study highlights acritical role of caspase-1 activation andNLPR3/ASCinflammasomecomplex in the down-modulation of IL-33 in vivo and in vitro,thereby regulating Th2 response in HDM-induced allergic lung inflammation. | Fahima Madouri Noelline Guillou Louis Fauconnier Tiffany Marchiol Nathalie Rouxel Pauline Chenuet Aurelie Ledru Lionel Apetoh Franc¸ois Ghiringhelli Mathias Chamaillard Song Guo Zheng Fabrice Trovero Valerie F.J.Quesniaux Bernhard Ryffel Dieudonnee Togbe | 2015 | Journal of Molecular Cell Biology2015，7，4： | 8 |
| 2 | The lncRNA APOLO interacts with the transcription factor WRKY42 to trigger root hair cell expansion in response to cold显示文摘Plant long noncoding RNAs(lncRNAs)have emerged as important regulators of chromatin dynamics,impacting on transcriptional programs leading to different developmental outputs.The lncRNA AUXIN-REGULATED PROMOTER LOOP(APOLO)directly recognizes multiple independent loci across the Arabidopsis genome and modulates their three-dimensional chromatin conformation,leading to transcriptional shifts.Here,we show that APOLO recognizes the locus encoding the root hair(RH)master regulator ROOT HAIR DEFECTIVE 6(RHD6)and controls RHD6 transcriptional activity,leading to cold-enhanced RH elongation through the consequent activation of the transcription factor gene RHD6-like RSL4.Furthermore,we demonstrate that APOLO interacts with the transcription factor WRKY42 and modulates its binding to the RHD6 promoter.WRKY42 is required for the activation of RHD6 by low temperatures and WRKY42 deregulation impairs cold-induced RH expansion.Collectively,our results indicate that a novel ribonucleoprotein complex with APOLO and WRKY42 forms a regulatory hub to activate RHD6 by shaping its epigenetic environment and integrate signals governing RH growth and development. | Michael Moison Javier Martinez Pacheco Leandro Lucero Camille Fonouni-Farde Johan Rodriguez-Melo Natanael Mansilla Aurelie Christ Jeremie Bazin Moussa Benhamed Fernando Ibanez Martin Crespi Jose M.Estevez Federico Ariel | 2021 | Molecular Plant2021，14，6： | 8 |
| 3 | Hallmarks in colorectal cancer:Angiogenesis and cancer stem-like cells显示文摘Carcinogenesis is a multistep process that requires the accumulation of various genetic and epigenetic aberrations to drive the progressive malignant transformation of normal human cells.Two major hallmarks of carcinogenesis that have been described are angiogenesis and the stem cell characteristic of limitless replicative potential.These properties have been targeted over the past decade in the development of therapeutic treatments for colorectal cancer(CRC),one of the most commonly diagnosed and lethal cancers worldwide.The treatment of solid tumor cancers such as CRC has been challenging due to the heterogeneity of the tumor itself and the chemoresistance of the malignant cells.Furthermore,the same microenvironment that maintains the pool of intestinal stem cells that contribute to the continuous renewal of the intestinal epithelia also provides the necessary conditions for proliferative growth of cancer stem-like cells.These cancer stem-like cells are responsible for the resistance to therapy and cancer recurrence,though they represent less than 2.5%of the tumor mass.The stromal environment surrounding the tumor cells,referred to as the tumor niche,also supports angiogenesis,which supplies the oxygen and nutrients needed for tumor development.Anti-angiogenic therapy,such as with bevacizumab,a monoclonal antibody against vascular-endothelial growth factor,significantly prolongs the survival of metastatic CRC patients.However,such treatments are not completely curative,and a large proportion of patient tumors retain chemoresistance or show recurrence.This article reviews the current knowledge regarding the molecular phenotype of CRC cancer cells,as well as discusses the mechanisms contributing to their maintenance.Future personalized therapeutic approaches that are based on the interaction of the carcinogenic hallmarks,namely angiogenic and proliferative attributes,could improve survival and decrease adverse effects induced by unnecessary chemotherapy. | Muriel Mathonnet Aurelie Perraud Niki Christou Hussein Akil Carole Melin Serge Battu Marie-Odile Jauberteau Yves Denizot | 2014 | World Journal of Gastroenterology2014，20，15： | 5 |
| 4 | Relativistic-intensity near-single-cycle light waveforms at kHz repetition rate显示文摘The development of ultra-intense and ultra-short light sources is currently a subject of intense research driven by the discovery of novel phenomena in the realm of relativistic optics,such as the production of ultrafast energetic particle and radiation beams for applications.It has been a long-standing challenge to unite two hitherto distinct classes of light sources:those achieving relativistic intensity and those with pulse durations approaching a single light cycle.While the former class traditionally involves large-scale amplification chains,the latter class places high demand on the spatiotemporal control of the electromagnetic laser field.Here,we present a light source producing waveformcontrolled 1.5-cycle pulses with a 719 nm central wavelength that can be focused to relativistic intensity at a 1 kHz repetition rate based on nonlinear post-compression in a long hollow-core fiber.The unique capabilities of this source allow us to observe the first experimental indications of light waveform effects in laser wakefield acceleration of relativistic energy electrons. | Marie Ouille Aline Vernier Frederik Bohle Maimouna Bocoum Aurelie Jullien Magali Lozano Jean-Philippe Rousseau Zhao Cheng Dominykas Gustas Andreas Blumenstein Peter Simon Stefan Haessler Jerome Faure Tamas Nagy Rodrigo Lopez-Martens | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 5 | Prognostic value of chemotherapy-induced hematological toxicity in metastatic colorectal cancer patients显示文摘AIM: To establish whether chemotherapy-induced neutropenia is predictive of better outcome in patients with metastatic colorectal cancer(mCRC). METHODS: Survival and patient characteristics from consecutive mCRC patients treated in the Centre Georges Francois Leclerc, Dijon, France between January 2001 and December 2011 were analyzed. Patient and tumor characteristics, hematological toxicity(neutropenia, anemia, and thrombocytopenia), and type of chemotherapy received were recorded. RESULTS: We retrospectively analyzed data from 399 consecutive patients with mCRC who received at least one line of chemotherapy. Median follow up was 6.3 years. Eighty-eight percent of the patients received more than two lines of chemotherapy. By univariate analysis, whatever their grade, neutropenia and thrombocytopenia occurring during the first two lines of chemotherapy were significantly associated with better overall survival(HR = 0.55, 95%CI: 0.43-0.70, P < 0.0001 and HR = 0.70, 95%CI: 0.56-0.88, P = 0.025 respectively). In contrast, anemia during chemotherapy was significantly associated with poorer overall survival(HR = 1.9, 95%CI: 1.22-2.97, P = 0.005). Multivariate analysis revealed that both neutropenia and thrombocytopenia were significantly associated with better overall survival: HR = 0.43, 95%CI: 0.29-0.64, P < 0.0001 and HR = 0.69, 95%CI: 0.49-0.98, P = 0.036, respectively. CONCLUSION: These data suggest that occurrence of neutropenia or thrombocytopenia during first- or second-line chemotherapy for mCRC is associated with better survival. | Laurie Rambach Aurelie Bertaut Julie Vincent Veronique Lorgis Sylvain Ladoire Francois Ghiringhelli | 2014 | World Journal of Gastroenterology2014，20，6： | 2 |
| 6 | Meta-analysis of calorimeter data to establish relationships between methane and carbon dioxide emissions or oxygen consumption for dairy cattle显示文摘Recent developments suggest the use of other gases such as carbon dioxide(CO_2) to estimate methane(CH_4)emissions from livestock,yet little information is available on the relationship between these two gases for a wide range of animals.A large respiration calorimeter dataset with dairy cattle(n=987 from 30 experiments)was used to investigate relationships between CH_4 and CO_2 production and oxygen(O_2)consumption and to assess whether the predictive power of these relationships could be improved by taking into account some dietary variables,including forage proportion,fibre and metabolisable energy concentrations.The animals were of various physiological states(young n=60,dry cows n=116 and lactating cows n=811)and breeds(Holstein-Friesian cows n=876,Jersey×Holstein-Friesian n=47,Norwegian n=50 and Norwegian×Holstein-Friesian n=14).The animals were offered forage as a sole diet or a mixture of forage and concentrate(forage proportion ranging from 10 to 100%,dry matter basis).Data were analysed using a series of mixed models.There was a strong positive linear relationship between CH_4and CO_2,and observations within an experiment were very predictable(adjusted R^2=0.93).There was no effect of breed on the relationship between CH_4 and CO_2.Using O_2 instead of CO_2 to predict CH_4 production also provided a very good fit to the observed empirical data,but the relationship was weaker(adjusted R^2=0.86).The inclusion of dietary variables to the observed CO_2 emissions,in particular forage proportion and fibre concentration,provided a marginal improvement to the prediction of CH_4.The observed variability in the CH_4:CO_2 ratio could only marginally be explained by animal physiological state(lactating vs.dry cows and young cattle)and dietary variables,and thus most likely reflected individual animal differences.The CH_4:CO_2 ratio can therefore be particularly useful to identify low CH_4 producing cows.These findings indicate that CO_2 production data can be used to accurately predict CH_4 emissions to generate large scale data for management and genetic evaluations for the dairy industry. | Aurelie Aubry Tianhai Yan | 2015 | Animal Nutrition2015，，3： | 2 |
| 7 | Prediction of the severity of colorectal lesion by fecal hemoglobin concentration observed during previous test in the French screening program显示文摘BACKGROUND The rate of positive tests using fecal immunochemical test(FIT)does not decrease with subsequent campaigns,but the positive predictive value of advanced neoplasia significantly decreases in subsequent campaign after a first negative test.A relationship between the fecal hemoglobin concentration(Fhb)and the opportunity to detect a colorectal cancer in subsequent campaign has been shown.AIM To predict the severity of colorectal lesions based on Fhb measured during previous colorectal cancer screening campaign.METHODS This etiological study included 293750 patients aged 50-74,living in Auvergne-Rhone-Alpes(France).These patients completed at least two FIT[test_((-1))and test_((0))]between June 2015 and December 2019.Delay between test_((-1))and test_((0))was>1year and test_((-1))result was negative(<150 ngHb/mL).The severity of colorectal lesions diagnosed at test_((0))was described according to Fhb measured at test_((-1))[Fhb_((-1))].The relationship between the severity classified in seven ordinal categories and the predictive factors was analyzed in an ordered multivariate polytomous regression model.RESULTS The test_((0))positive rate was 4.0%,and the colonoscopy completion rate was 97.1%in 11594 patients who showed a positive test_((0)).The colonoscopy detection rate was 77.7%in those 11254 patients who underwent a colonoscopy.A total of 8748 colorectal lesions were detected(including 2182 low-risk-polyps,2400 high-riskpolyp,and 502 colorectal cancer).The colonoscopy detection rate varied significantly with Fhb_((-1))[0 ngHb/mL:75.6%,(0-50 ngHb/mL):77.3%,(50-100 ngHb/mL):88.7%,(100-150 ngHb/mL):90.3%;P=0.001].People with a Fhb_((-1))within(100-150 ngHb/mL)(P=0.001)were 2.6(2.2;3.0)times more likely to have a high severity level compared to those having a Fhb_((-1))value of zero.This risk was reduced by 20%in patients aged 55-59 compared to those aged<55[adjusted odds ratio:0.8(0.6;1.0)].CONCLUSION The study showed that higher Fhb_((-1))is correlated to an increased risk of severity of colorectal lesions.This risk of severity increased among first-time participants(age<55)and the elderly(≥70).To avoid the loss of chance in these age groups,the FIT positivity threshold should be reduced to 100 ngHb/mL.The other alternative would be to reduce the time between the two tests in these age groups from the current 2 years to 1 year. | Christian Balamou Akoi Koivogui Christelle M Rodrigue Aurelie Clerc Claire Piccotti Anne Deloraine Catherine Exbrayat | 2021 | World Journal of Gastroenterology2021，27，31： | 2 |
| 8 | Identification of a CD4 T-cell epitope in the hemagglutinin stalk domain of pandemic H 1N 1 influenza virus and its antigen-driven TCR usage signature in BALB/c mice显示文摘流行性感冒病毒红血球凝聚素的梗区域很好相对与球状的头领域相比被保存,它对流行性感冒用作一支通用疫苗使它成为一个潜在的目标。然而,在红血球凝聚素的 CD4 T 房间的角色梗特定的有免疫力的反应不是清楚的。这里,我们识别了在流行性感冒的尚不致命的感染以后从红血球凝聚素梗领域包含残余 HA2 113-131 的老鼠 CD4 T 房间 epitope。响应有识别 epitope 的刺激,从感染的老鼠导出的 splenocytes 显示出象 degranulation 一样由 IL-2, TNF- 和 IFN- 生产出现的重要 polyfunctionality。而且,与相应于这 CD4 T 房间 epitope 的肽使免疫的老鼠展出了 CD4 T 房间受体分享的 interindividual 序列,和他们有更高的幸存率与流行 H1N1 流行性感冒的致命的剂量跟随挑战病毒。因此,我们的数据表明了红血球凝聚素的一个关键角色在对流行性感冒病毒感染的主机免疫者反应的梗特定的 CD4 T 房间。 | I-Na Lu Sophie Farinelle Aurelie Sausy Claude P Muller | 2017 | Cellular & Molecular Immunology2017，14，6： | 2 |
| 9 | SPOT 5 HRS Geometric Performances: Using Block Adjustment as A Key Issue to Improve Quality of DEM Generation 显示文摘 | Aurelie Bouillon Marc Bernard Patrick Gigord | 2006 | ISPRS Journal of Photogrammetry & Remote Sensing (S0924-2716)2006，60，3： | 1 |
| 10 | Validation of a commercial real-time PCR kit for specific and sensitive detection of Pseudorabies 显示文摘 | Francoise P Celine D Aurelie O | 2013 | J Virol Methods2013，187，2： | 1 |
| 11 | Screening of In Vivo Activated Genes in Enterococcus faecalis during Insect and Mouse Infections and Growth in Urine显示文摘 | Aurelie H Irina S YinYin B | 2010 | PLoS One2010，5，7： | 1 |
| 12 | FiveDisruptive Technology Directions for 5G 显示文摘 | Federico Boccardi Heath R W Aurelie Lozano | 2014 | Communica-tions Magazine IEEE2014，52，2： | 1 |
| 13 | Combination of R207910 with drugs used to treat muhidrug- resistant tuberculosis have the potential to shorten treatment duration 显示文摘 | Nacer Lounis Nicolas Veziris Aurelie Chauffour | 2006 | Antimicrob Agents Chemother2006，50，11： | 1 |
| 14 | Cytotoxicity and cbll cycle effects of the plant alkaloids eryptolepine and neocryptolepine: relation to drug induced apoptosis 显示文摘 | Laurent D Amelie L Aurelie W | 2000 | Europ J Pharmacol2000，409，1： | 1 |
| 15 | Response of cultured tomato cellssubjected to excess zinc:role of cell wall in zinc compartmentation显示文摘 | AURELIE M CELINE F HENRI M | 2009 | Acta Physiologiae Plantarum2009，31，6： | 1 |
| 16 | Polysaccharide Gels Based on Chitosan and Modified Starch:Structural Characterization and Linear Viscoelastic Behavior 显示文摘 | Aurelie Serrero Stephane Trombotto Philippe Cassagnau | 2010 | Biomacromolecules2010，，11： | 1 |
| 17 | Proteomic characteization of the acid tolerance response in Lactococcus lactis MG1363显示文摘 | Aurelie Budin-Verneuil Vianney Pichereau and Yanick Auffray | 2005 | Proteomics2005，5，： | 1 |
| 18 | Stepwise process for the development of Entecavir resistance in a chronic hepatitis B virus infected patient显示文摘 | Stephanie V Aurelie O Christian P | 2007 | Hepatology2007，1，46： | 1 |
| 19 | Solid lipid nanoparticles for targeted brain drug delivery显示文摘 | Paolo B Stefano G Aurelie S | 2007 | Adv Drug Deliv Rev2007，59，6： | 1 |
| 20 | N2O and CH4 emissions from soils under conventional and no-till management practiees in Goiania (Cerrados,Brazil) 显示文摘 | AURELIE M ROBERT O ERIC S | 2007 | Geoderma2007，141，： | 1 |
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