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| 1 | Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome显示文摘AIM: To determine whether Lactobacillus casei strain Shirota (Yakult ) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome (IBS). METHODS: 18 patients with IBS (Rome Ⅱ criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of f irst rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no signifi cant improvement in the symptom score with probiotic therapy, except for wind (P=0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median fi nal score 5.3 (IQR3.9-5.9), 55% reduction; n=6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18]. CONCLUSION: Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these fi ndings awaits a randomised, controlled trial. | Jacqueline S Barrett Kim EK Canale Richard B Gearry Peter M Irving Peter R Gibson | 2008 | World Journal of Gastroenterology2008，14，32： | 16 |
| 2 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 3 | A Multidimensional Trust Formation Model in B-to-C Ecommerce:A Conceptual Framework and Content Analyses of Academia/Practitioner Perspectives 显示文摘 | Kim D J Song Y I Braynov S B Rao H R | 2005 | Decision Support Systems2005，40，2： | 1 |
| 4 | A study of magnetic and optical properties of Cu-doped ZnO 显示文摘 | LEE H J KIM B S CHO C R | 2004 | Phys Status Solidi B2004，241，7： | 1 |
| 5 | Determintion of melamine in pet food by enzyme immunoassay, high- performance liquid chromatography with diode array detection, and ultra-performance liquid chromatography with tandem mass spectrometry显示文摘 | KIM B PERKINS L B BUSHWAY R J | 2008 | J AOAC Int2008，91，： | 1 |
| 6 | Electricity generation from swine wastewater using microbialfuel cells显示文摘 | Min B Kim J R Oh S E | 2005 | Water Res2005，39，20： | 1 |
| 7 | Performance of tin doped titania hollow spheres as electrocatalysts for hydrogen and oxygen production in water electrolysis显示文摘 | CHATTOPADHYAY J KIM H R MOON S B | 2008 | International Journal of Hydrogen Energy2008，33，13： | 1 |
| 8 | Electricity generation from swine wastewater using microbial fuel cells显示文摘 | MIN B KIM J R OH S E | 2005 | Water Research2005，39，20： | 1 |
| 9 | Molecular dynamics study of SWNT growth on catalyst particles without temperature gradients显示文摘 | Feng D Kim B Arne R | 2005 | Comp Mater Sei2005，35，： | 1 |
| 10 | A novel gene,Pi40 (t) ,linked to the DNA markers derived from NBS-LRR motifs confers broad spectrum of blast resistance in rice 显示文摘 | Jeung J U Kim B R Cho Y C | 2007 | Theor Appl Genet2007，，115： | 1 |
| 11 | Pseudomonas type Ⅲ effector AvrPtoB induces plant disease susceptibility by inhibition of host programmed cell death显示文摘 | Abramovitch R B Kim | 2003 | EMBO J2003，20，： | 1 |
| 12 | The relationship of sarcoplasmic and myofibrillar protein solubility to colour and water- holding capacity in porcine longissimus muscle显示文摘 | JOO S T KAUFFMAN R G KIM B C | 1999 | Meat Science1999，52，3： | 1 |
| 13 | Mechanical properties and rapid consolidation of binderless nanostruetured tantalum carbide显示文摘 | Kim B R Woo K D DUb J M | 2009 | Ceram Int2009，35，： | 1 |
| 14 | 查看详情显示文摘 | (e) Kim D C Lee Y R Yang B -S Shin K J Kim D J Chung B Y Yoo K H | | 0，，： | 1 |
| 15 | Electricity generation from swine wastewater using microbial fuel cells显示文摘 | Min B Kim J R Oh S E | 2005 | Water Research2005，39，20： | 1 |
| 16 | Photochemical Destruction of Cyanide in Landfdl Leachate 显示文摘 | Kim B R Podsiadlik D H Kalis E M | 1998 | Journal of Environmental Engineering1998，，11： | 1 |
| 17 | Multispectral detection of organic residues on poultry processing plant equipment based on hyperspectral refl ectance imaging technique显示文摘 | Cho B K Chen Y R Kim M S | 2007 | Computers and Electronics in Agriculture2007，57，2： | 1 |
| 18 | PLL/DLL system noise analysis for low jitter clock synthesizer design 显示文摘 | KIM B GRAY P R | 2005 | IEEE custom integrated circuits conference2005，35，6： | 1 |
| 19 | Performance of tin doped titania hollow spheres as electrocatalysts for hydrogen and oxygen production in Water electrolysis显示文摘 | Chattopadhyay J Kim H R Moon S B | 2008 | International Journal of Hydrogen Energy2008，33，13： | 1 |
| 20 | Analysis of treatment modalities and their failures in stage IB cancer of the cer- vix显示文摘 | KIM R Y SLATER M M WEPPELMANN B | 1988 | Int J Radiat Oncol Biol Phys1988，15，4： | 1 |
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