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| 1 | Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis显示文摘AIM:To investigate the association of macrophage migration inhibitory factor(MIF)promoter polymorphisms with inflammatory bowel disease(IBD)risk.METHODS:One thousand and six New Zealand Caucasian cases and 540 Caucasian controls were genotyped for the MIF SNP-173G>C(rs755622)and the repeat polymorphism CATT5-8(rs5844572)using a predesigned TaqMan SNP assay and capillary electrophoresis,respectively.Data were analysed for single site and haplotype association with IBD risk and phenotype.Meta-analysis was employed,to assess cumulative evidence of association of MIF-173G>C with IBD.All published genotype data for MIF-173G>C in IBD were identified using PubMed and subsequently searching the references of all PubMed-identified studies.Imputed genotypes for MIF-173G>C were generated from the Wellcome Trust Case Control Consortium(and National Institute of Diabetes and Digestive and Kidney Diseases).Separate meta-analyses were performed on Caucasian Crohn’s disease(CD)(3863 patients,6031controls),Caucasian ulcerative colitis(UC)(1260 patients,1987 controls),and East Asian UC(416 patients and 789 controls)datasets using the Mantel-Haenszel method.The New Zealand dataset had 93%power,and the meta-analyses had 100%power to detect an effect size of OR=1.40 atα=0.05,respectively.RESULTS:In our New Zealand dataset,single-site analysis found no evidence of association of MIF polymorphisms with overall risk of CD,UC,and IBD or disease phenotype(all P values>0.05).Haplotype analysis found the CATT5/-173C haplotype occurred at a higher frequency in New Zealand controls compared to IBD patients(0.6 vs 0.01;P=0.03,OR=0.22;95%CI:0.05-0.99),but this association did not survive bonferroni correction.Meta-analysis of our New Zealand MIF-173G>C data with data from seven additional Caucasian datasets using a random effects model found no association of MIF polymorphisms with CD,UC,or overall IBD.Similarly,meta-analysis of all published MIF-173G>C data from East Asian datasets(416UC patients,789 controls)found no association of this promoter polymorphism with UC. | James D Falvey Robert W Bentley Tony R Merriman Mark B Hampton Murray L Barclay Richard B Gearry Rebecca L Roberts | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 3 | AHA更新血压处理指南显示文摘 | Barclay L 罗雪琚(编译) | 2007 | 心血管病学进展2007，28，2： | 2 |
| 4 | NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD. | Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 5 | Stochastic modeling of electrical treeing: Fractal and statistical charac teristics显示文摘 | Barclay A L Sweeney P J Dissado L A | 1990 | J Phys D: Appl Phys1990，23，： | 1 |
| 6 | Disk position and the bilaminar zone of the temporomandibular joint in asymptomatic young individuals by magnetic resonance imaging显示文摘 | Haiter-Neto F Hollender L Barclay P | 2002 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2002，94，3： | 1 |
| 7 | On the antioxidantmechanism of curcumin:classic methods are needed to determine antioxidantmechanism and activity显示文摘 | Vinqvist M R Barclay L R | 2000 | O rg Lett2000，2，18： | 1 |
| 8 | Novel surveillance network for norovirus gastroentefitis outbreaks, United States 显示文摘 | Vega E Barclay L Gregoricus N | 2011 | Emerg Infect Dis2011，17，8： | 1 |
| 9 | Other-cell interference and reverse link capacity of high altitude platform station CDMA system 显示文摘 | Foo Y C Lim W L Tafazolli R Barclay L | 2000 | Electronics Letters2000，36，22： | 1 |
| 10 | Esophagogastroduodenoscopy-assisted bowel preparation for colonoscopy显示文摘AIM:To compare the quality and tolerance of esophag ogastroduodenoscopy(EGD)-assisted and conventional split-dose polyethylene glycol electrolyte solution for inpatient colonoscopy.METHODS:The study was a randomized controlled trial in hospitalized patients.Hospitalized patients undergoing colonoscopy the day following EGD for evaluation of gastrointestinal(GI) bleeding or other symptoms.Patients randomized to either EGD-assisted bowel prep [2 L polyethylene glycol(PEG) administered endoscopically into distal duodenum at time of EGD,plus 1 L PEG orally the following day] or conventional-PEG(2 L PEG orally the evening prior and 1 L PEG orally the following day).The main outcome measurements are bowel preparation quality and patient tolerance of bowel prep.RESULTS:Forty-two patients randomized to EGD-assisted bowel prep and 40 patients to conventional-PEG.Overall mean ± SD preparation quality was superior for EGD-PEG(4.1 ± 2.8) vs conventional-PEG(6.5 ± 3.1;P = 0.0005).Seventy-four percent of patients rated EGDPEG as easy or slightly difficult to tolerate compared to 46% for standard-PEG(P = 0.0133).Mean EGD-procedural time was greater for EGD-assisted subject(24 ± 10 min) compared to conventional-PEG prep subjects(15 ± 7 min;P < 0.0001).Conscious sedation requirements did not differ between groups.There were no significant prep-related adverse events in either group.CONCLUSION:In selected hospitalized patients,compared to a conventional split-dose regimen,use of EGD to administer the majority of PEG solution improves patient tolerance and quality of bowel preparation for colonoscopy. | Robert L Barclay | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 1 |
| 11 | Stochastic modelling of electrical treeing:fractal and statistical characteristics显示文摘 | Barclay A Sweeney P Dissado L | 2000 | Journal of Physics D:Applied Physics2000，23，12： | 1 |
| 12 | ‘ No more strangers' : Investigating the experiences of women, midwives and others during the establishment of a new model of maternity care for remote dwelling aboriginal women in northern Australia 显示文摘 | Josif C M Barclay L Kruske S | 2014 | Midwifery2014，30，3： | 1 |
| 13 | Media Effects on Anlioxidant Activitics Of Phenols and Calechols显示文摘 | Barclay L R Edwards C E Vinqvist M R | 1999 | Journal of the American Chemical Society1999，121，： | 1 |
| 14 | Effect of shifting policies on traditional birth attendant training 显示文摘 | Kruske S Barclay L | 2004 | Midwifery Women Health2004，49，4： | 1 |
| 15 | SOCS3 as a tumor suppressor in breast cancer cells, and its regulation by PRL显示文摘 | Barclay J L Anderson S T Waters M J | 2009 | International Journal of Cancer2009，124，8： | 1 |
| 16 | When explanation for layoffs are not enough:Employer's integrity as a moderator of the relationship between informational justice and retaliation显示文摘 | Skarlicki D P Barclay L J Pugh D | 2008 | Journal of Occupational and Organizational Psychology2008，81，1： | 1 |
| 17 | Chainbreaking phenolic antioxidants : steric and electronic effects in polyalkylchromanols, tocopherol analogs, hydroquinones, and superior antioxidants of the polyalkylbenzochromanol and naphthofuran class 显示文摘 | Barclay L R C Vinqvist M R Mukai K | 1993 | J Org Chem1993，58，： | 1 |
| 18 | Effect of psychological stress on salt and water transport in the human jejunum显示文摘 | Barclay G R Turnberg L A | 2007 | Gastroenterology2007，93，： | 1 |
| 19 | Disk position and the bilaminar zone of the temporomandibular joint in a- symptomatic young individuals by magnetic resonance imaging 显示文摘 | Haiter-Neto F Hollender L Barclay P | 2002 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2002，94，3： | 1 |
| 20 | On the antioxidant mechanism of cureumin: Classical methods are needed to determine antioxidant mechnism and activity显示文摘 | Barclay L R C Vinqvist M R Mukai K | 2000 | Org Lett2000，2，18： | 1 |
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