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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 3 | Recombinant bovine somatotropin and clinical mastitis incidence, discarded milk following therapy and culling显示文摘 | JUDGE L J ERSKINE R J BARTLETT P C | 1997 | J Dairy Sci1997，80，： | 2 |
| 4 | Silica particles:A novel drug-delivery system显示文摘 | BARBE C BARTLETT J KONG L | 2004 | Advanced Materials2004，16，21： | 1 |
| 5 | Systematic review of long term effects of advice to reduce dietary salt in adults 显示文摘 | Hooper L Bartlett C Smith GD | 2002 | BMJ2002，325，21： | 1 |
| 6 | Root location of an entire polytope of polynomials: It suffices to check the edges 显示文摘 | Hollot C V Huang L | 1988 | Mathematic Control Signals Systems1988，1，1： | 1 |
| 7 | Silica particles: a novel drug-delivery system显示文摘 | BARBE C BARTLETT J KONG L G | 2004 | Adv Mater2004，16，21： | 1 |
| 8 | False recency and false fame of faces in old age显示文摘 | Bartlett J C Strater L Fulton A | 1991 | Memory and Cognition1991，19，2： | 1 |
| 9 | New Support Vector Algorithms显示文摘 | B Scholkopf R C Williamson P L Bartlett | 2000 | Neural Computation2000，12，5： | 1 |
| 10 | Root locations for an entire polytope of polynomial: it suffices to check the edges显示文摘 | Bartlett A C Hollot C V Huaog L | 1988 | Math Contr Signals Syst1988，1，1： | 1 |
| 11 | Advice to reduce dietary salt for prevention of cardiovascular disease显示文摘 | Hooper L Bartlett C Davey SG | 2004 | Cochrane Database Syst Rev2004，1，： | 1 |
| 12 | Ligation ofintersphincteric fistula tract compared with advancement flap forcomplex anorectal fistulas requiring initial seton drainage 显示文摘 | Mushaya C Bartlett L Schulze B Ho YH | 2012 | Am J Surg2012，204，： | 1 |
| 13 | A prospective analysis of the frequency, location, and curability of ectopic (nonpancreaticoduodenal, nonnodal) gastrinoma显示文摘 | Peter C Wu H.Richard Alexander David L Bartlett John L Doppman Douglas L Fraker Jeffrey A Norton Fathia Gibril Franz Fogt Robert T Jensen | 1997 | Surgery1997，，6： | 1 |
| 14 | Silica Particles: A novel drug-delivery system显示文摘 | Barbe C Bartlett J Kong L | 2004 | Advanced Materials2004，16，21： | 1 |
| 15 | Structural risk minimization over data-dependent hierarchies显示文摘 | Shawe T J Bartlett P L Williamson R C | 1998 | IEEE Trans Inf Theory1998，44，： | 1 |
| 16 | Silica particles: a novel drug-system 显示文摘 | BARBE C BARTLETT J KONG L G | 2004 | Adv Mater2004，16，： | 1 |
| 17 | Efficacy of systemic ceftiofur as a therapy for severe clinical mastitis in dairy cattle显示文摘 | Erskine R J Bartlett P C VanLente J L | | 0，，10： | 1 |
| 18 | Balancing benefits and harms: the example of non-steroidal anti-inflammatory drugs显示文摘 | Dieppe P Bartlett C Davey P Doyal L Ebrahim S | 2004 | BMJ2004，2562，329： | 1 |
| 19 | Immune gene discovery by expressed sequence tag analysis of haemo- cytes and hepatopancreas in the Pacific White Shrimp, Litopenaeus vannamei, and the Atlantic White Shrimp, Litopenaeus setiferus 显示文摘 | Gross P S Bartlett T C Browdy C L | 2001 | Developmental and Compara- tive Immunology2001，25，7： | 1 |
| 20 | Efficacy off systemic ceftiofur as a therapy for severe clinical mastitis in dairy cattle显示文摘 | Erskine R J Bartlett P C Vanlente J L | 2002 | Journal of Dairy Science2002，85，10： | 1 |
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