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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Recognition and reaction of metallointercalators with DNA显示文摘 | ERKKILA K E ODOM D T BARTON J K | 1999 | Chem Rev1999，99，： | 1 |
| 3 | Analysis of variation in isolates of Rhizoctonia solani by random amplified polymorohic DNA assay显示文摘 | Duncan S Barton J E O'brien P A | 1993 | Mycol Res1993，15，： | 1 |
| 4 | Who cares about auditor reputation? 显示文摘 | Barton J | 2005 | Contemporary Accounting Re- search2005，22，3： | 1 |
| 5 | 显示文摘 | Bahri P A Bandani J A Barton G W | 1995 | Computers and Chemical Engineering1995，，： | 1 |
| 6 | Analysis of variation in isolates of Rhizoctonia solani by random amplified polymorphic DNA assay显示文摘 | Duncan S Barton J E O′Brien P A | 1993 | Mycol Res1993，97，9： | 1 |
| 7 | Effects of Soil Conservation Measures on Erosion Rates and Crop Productivity on Subtropical Ultisols in Yunnan Province,China显示文摘 | BARTON A P FULLEN M A MITCHELL D J | 2004 | Agriculture Ecosystems and Environment2004，104，2： | 1 |
| 8 | Does the use of financial derivatives affect earnings management decisions? 显示文摘 | Barton J | 2001 | The Accounting Review2001，76，1： | 1 |
| 9 | Intellectual property rights:Reforming the patent system 显示文摘 | Barton J | 2000 | Sci2000，287，5460： | 1 |
| 10 | Monitoring floods with AVHRR 显示文摘 | Barton I J Bathols J M | 1989 | Remote Sensing of Environment (S0034-4257)1989，30，1： | 1 |
| 11 | The Relationship between Seismic Velocity andDensity in the Continental Crust :A Useful Constrain显示文摘 | Barton P J | 1986 | Geophys J R Astr Soc1986，87，1： | 1 |
| 12 | Transmission line resistance compression networks and applications to wireless power transfer显示文摘 | BARTON T W GORDONSON J M PERREAULT D J | 2015 | IEEE Journal of Emerging and Selected Topics in Power Electronics2015，3，1： | 1 |
| 13 | Expectant management of severe preeclampsia at 27 (0/7) to 33 ( 6/7 ) weeks gestation : maternal and perinatal outcomes according to gestational age by weeks at onset of expectant management 显示文摘 | BOMBRYS A E BARTON J R HABLI M | 2009 | American Journal of Perinatology2009，26，6： | 1 |
| 14 | Evidence that monoclonal antibodies directed against the integrin β subunit plexin/ semaphorin/integrin domain stimulate function by inducing receptor extension显示文摘 | Mould A P Travis M A Barton S J | 2005 | J Biol Chem2005，280，6： | 1 |
| 15 | Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic,an angiotensin-converting enzyme inhibitor,or an angioteasin receptor blocker显示文摘 | O'Brien E Barton J Nussberger J | 2007 | Hypertension2007，49，： | 1 |
| 16 | Characterizing perflu- orooctanoate in ambient air near the fence line of a manufacturing facility : Comparing modeled and monitored values 显示文摘 | Barton C Butler L E Zarzecki C J | 2006 | Journal of Air Waste Managenvent Association2006，56，1： | 1 |
| 17 | The manahement of placenta percreta: con-servative and operative stragtegies 显示文摘 | O'Brien JM Barton J R Donaldson E S | 1996 | Am J Obstet Gynecol1996，175，6： | 1 |
| 18 | Expectant management of severe preeclampsia at 27(0/7) to 33(6/7) weeks' gestation:maternal and perinatal outcomes according to gestational age by weeks at onset of expectant management显示文摘 | Bombrys A E Barton J R Habli M | 2009 | Am J Perinatol2009，26，6： | 1 |
| 19 | Distinct Amygdala-autonomic Arousal Profiles in Response to Fear Signals in Healthy Males and Females显示文摘 | WILLIAMS L M BARTON M J KEMP A H | 2005 | Neuroimage2005，，28： | 1 |
| 20 | Engineering classification of rock masses for the design of tunnel support显示文摘 | Barton N Lien R Lunde J | 1974 | Rock Mech1974，6，4： | 1 |
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