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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | An efficient algorithm for analysis of nonlinear heat transfer with phase changes显示文摘 | Donald Rolph W Bathe K J | 1982 | International Journal for Numerical Methods in Engineering1982，18，： | 2 |
| 4 | Finite element formulation and solution of nonlinear heat transfer显示文摘 | Bathe K J Khoshgoftaar M R | 1979 | Nuclear Engineering and Design1979，51，： | 2 |
| 5 | On the stability of mixed finite element in large strain analysis of incompressible solids显示文摘 | Pantuso D Bathe K J | 1997 | Finite Element Analysis and Design1997，28，： | 1 |
| 6 | Genetic variant BDNF (Va166Met) polymorphism alters anxiety-related behavior 显示文摘 | CHEN Z Y JING D BATH K G | 2006 | Science2006，314，： | 1 |
| 7 | Finite element free surface seepage analysis without mesh iteration显示文摘 | Bathe K J Khoshgoftaar M R | 1979 | Numerical analytical methods in Geomechanics1979，3，1： | 1 |
| 8 | The Gradient of the Finite Element Variational Indicator with Respect to NodalPoint co-ordinates: an Explicit Calculation and Applications in Fracture Mechanics and Mesh Optimization显示文摘 | Theodore Sussman Bathe K J | 1985 | International Journal for Numerical Methods in Engineering1985，21，6： | 1 |
| 9 | Conserving energy and momentum in nonlin- ear dynamics: A simple implicit time integration scheme显示文摘 | Bathe K | 2007 | Computers & Structures2007，85，78： | 1 |
| 10 | Analysis of fluid-structure interactions,a direct symmetric coupled formulation based on the fluid velocity potential显示文摘 | Olson L G Bathe K J | 1985 | Computers and Structures1985，，21： | 1 |
| 11 | A mesh adaptivity procedure for CFD and fluid-structure interactions显示文摘 | Bathe K J Zhang H | 2009 | Computers and structures2009，87，1112： | 1 |
| 12 | 查看详情显示文摘 | K Bathe | | 0，，： | 1 |
| 13 | Performance of a new partitioned procedure versus a monolithic procedure in fluid-structure interaction显示文摘 | DEGROOTE J BATHE K J VIERENDEELS J | | 0，，： | 1 |
| 14 | Nonlinear dy- namic analysis of complex structures显示文摘 | Wilson E L Farhoomand I Bathe K J | 1973 | Earthquake Engineering and Structural Dynamics1973，1，3： | 1 |
| 15 | Stability and accuracy analysis ofdirect integration methods 显示文摘 | Bathe K J Wilson E L | 1973 | Earthquake Engineeringand Structure Dynamics1973，1，3： | 1 |
| 16 | A solution method for static and dynamic analysis of three-dimendional contact problems with friction显示文摘 | Bathe K J | 1986 | Comp & Struc1986，24，6： | 1 |
| 17 | A formulation of general shell elements-the use of mixed interpolation of tensorial components显示文摘 | BATHE K J DVORKIN E N | 1986 | Int J Numer Methods Eng1986，22，3： | 1 |
| 18 | Some computation issues in large str-ain elasto-plastic analysis显示文摘 | Gabriel G Bathe K J | 1995 | Computers & Structures1995，56，： | 1 |
| 19 | Quality evaluation of different types of Indian honey 显示文摘 | SINGH N BATH P K | 1997 | Food Chemistry1997，，58： | 1 |
| 20 | A flow-condition-based interpolation finite element procedure for incompressible fluid flows显示文摘 | Bathe K J Zhang H | 2002 | Computers and Structures2002，80，： | 1 |
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