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| 1 | Keratinocyte 生长 factor-2 和自体同源的浆液加强处于在老鼠的角膜损坏的间充质的干细胞的再生效果显示文摘AIM:To investigate the healing process after severe corneal epithelial damage in rats treated with mesenchymal stem cells(MSCs)cultured with or without keratinocyte growth factor(KGF-2)and autologous serum(AS)on amniotic membrane(AM).Many patients are blind and devastated by severe ocular surface diseases due to limbal stem cell deficiency.Bone marrow-derived MSCs are potential sources for cellbased tissue engineering to repair or replace the corneal tissue,having the potential to differentiate to epithelial cells.METHODS:The study included 5 groups each including 10 female'Sprague Dawley'rats in addition to20 male rats used as bone marrow donors.Group I rats received AM+MSCs,Group II rats AM+MSCs cultured with KGF-2,Group III rats AM+MSCs cultured with KGF-2+AS,Group IV rats only AM and Group V rats,none.AS was derived from blood drawn from male rats and bone marrow was obtained from the femur and tibia bones of the same animals.Therapeutic effect was evaluated with clinical,histopathological and immunohistochemical assessment.MSC engraftment was demonstrated via detection of donor genotype(Y+)in the recipient tissue(X)with polymerase chain reaction.RESULTS:Corneal healing was significantly better in Groups I-III rats treated with MSC transplantation compared to Group IV and Group V rats with supportive treatment only.The best results were obtained in Group III rats with 90%transparency,70%lack of neovascularization,and 100%epithelium damage limited to less than 1/4 of cornea.CONCLUSION:We suggest that culture of MSCs with KGF-2 and AS on AM is effective in corneal repair in case of irreversible damage to limbal stem cells. | Ferda Alpaslan Pinarli Gülsen Okten Umit Beden Tunc Fisgin Mehmet Kefeli Nurten Kara Feride Duru Leman Tomak | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 2 | Fourier transform infrared reflectance spectroscopic investigation of the electro catalytic oxidation of D?glucose: Identification of reactive intermediates and reaction products显示文摘 | Beden B Largeaud F Kokoh K B | 1996 | Electrochimica Acta1996，41，： | 1 |
| 3 | Electrocatalytic oxidation of methanol on platinum-based binary electrodes显示文摘 | BEDEN B KADIRGAN F LAMY C | 1981 | Journal of Electroanalytical Chemistry1981，127，1： | 1 |
| 4 | Synergistic effect in the electrocatalytic oxidation of methanol on platinum palladium alloy electrodes 显示文摘 | Kadirgan F Beden B Leger J M | 1981 | J Electroanal Chem1981，125，： | 1 |
| 5 | Chemisorption of methanol on different platinum electrodes (smooth and rough polycrystalline,monocrystalline, and preferentially oriented)显示文摘 | ENIRS BEDEN B HAHEF | 1989 | J Electroanal Chem1989，261，： | 1 |
| 6 | Unsuccessful probing and nasolacrimal canal agenesis in congenital epiphora 显示文摘 | Deniz TC Umit Beden Baris Sonmez | 2010 | Orbit2010，29，6： | 1 |
| 7 | The electrooxidation of CO : a test reaction in electrocatalysis 显示文摘 | Beden B Lamy C Tacconi N R D | 1990 | Electroehim Aeta1990，35，4： | 1 |
| 8 | Electrocatalytic oxidation of methanol on platinum-based binary electrodes 显示文摘 | BEDEN B KARDIGAN F LAMY C | 1981 | J Electroanal Chem1981，127，： | 1 |
| 9 | Carbon monoxide electrosorption on low index platinum single crystal electrodes 显示文摘 | Leger J M Beden B Lamy C | 1984 | J Electroanal Chem1984，170，： | 1 |
| 10 | Effect of inoculum size on the antibacterial activity of cefepime and cefepime against Klebsiella pneumoniae strains producing SHV extended - spectrum beta - latamases 显示文摘 | Bedenic B Beader N Zagar Z | 2001 | Clin Microbiol Infect2001，7，： | 1 |
| 11 | First report of molecular characterization of carbapenem-resistant Acinetobacter baumannii in different intensive care units in university hospital split,Croatia 显示文摘 | Barisic GB Bedenic B Tonkic M | | J Chemotherapy0，19，4： | 1 |
| 12 | Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects显示文摘 | Beden G Lebed B Schatz M | 2001 | Diabetes2001，50，： | 1 |
| 13 | Coupled thermo-mechanical finite-element modeling of hot ring rolling process 显示文摘 | SONG J L DOWSON A L JACOBS M H BROOKS J BEDEN I | 2002 | Journal of Materials Processing Technology2002，121，： | 1 |
| 14 | Sensitivity and specificity of various Beta-Lactam antibiotics and phenotypical methods for detection of TEM, SHV and CTX-M extended-spectrum beta- lactamases显示文摘 | Bedenic B Vranes J Mihaljevic L | 2007 | J Chemother2007，19，2： | 1 |
| 15 | In-situ synchrotron far infrared spectroscopy of surface film on a copper electrode in aqueous solutions显示文摘 | BOWMAKER G A LEGER J M BEDEN B | 1998 | J Electroanal Chem1998，449，： | 1 |
| 16 | Effects of pars plana vitrectomy On retrobulbar hemodi- namics in diabetic retinopathy 显示文摘 | Sullu Y Hamidova R Beden U Yakupov K Canbaz S Danaci M | 2005 | Clin Experiment Ophthalmol2005，33，3： | 1 |
| 17 | Selective oxidation of lactose to lactobionic acid on lead-adatoms modified platinum electrodes in Na2CO3 + NaHCO3 buffered medium显示文摘 | DRULIOLLE H KOKOH K B BEDEN B | 1995 | Journal of Electroanalytical Chemistry1995，385，1： | 1 |
| 18 | First report of molecular characterization of carbapenem-resistant Acinetobacter baumannii in different intensive care units in university hospital split,Croatia显示文摘 | Barisic GB Bedenic B Tonkic M | 2007 | J Chemotherapy2007，19，4： | 1 |
| 19 | Comparison of Central Corneal Thickness Measurements by Galilei Dual-Scheimpflug Analyzer? and Ultrasound Pachymeter in Myopic Eyes显示文摘 | Yeter Volkan S?nmez Baris Beden ümit | 2012 | EN2012，，2： | 1 |
| 20 | Electrocatalytic oxidation of glucose at platinum in alkaline medium : on the role of temperature 显示文摘 | Essis Yei L H Beden B Lamy C | 1988 | J Electroanal Chem1988，246，： | 1 |
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