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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | Infectious hypodermal and hematopoietic necrosis, a newly recognized virus disease of penaeid shrimp显示文摘 | Lightner D V Redman R M Bell T A | 1983 | Invertebrate Pathology1983，42，： | 2 |
| 3 | The effect of the stre ngth properties of wool staples on worsted processing,Part Ⅰ:The level of staple strength 显示文摘 | Rottenbury R A Andrews M W Bell P J M | 1986 | J Text Inst1986，，77： | 2 |
| 4 | Optical properties of the metals Al, Co, Cu, Au, Fe, Pb, Ni, Pd, Pt, Ag, Ti, and W in the infrared and far infrared 显示文摘 | Ordal M A Long L L Bell R J | 1983 | Applied Optics1983，22，7： | 2 |
| 5 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 6 | A annotated checklist of the mosses of Europe and Macaronesia 显示文摘 | Hill M O Bell N Bruggeman-Nannenga M A | 2006 | Journal of Bryology2006，28，： | 1 |
| 7 | Synthesis and characterization of polypyrrole-magnetite-silica particles显示文摘 | Btterworth M D Bell S A Armes S P Simpson A W | 1996 | J Colloid Interf Sci1996，183，： | 1 |
| 8 | Analysis of fMRI data by blind separation into independent spatial components 显示文摘 | Mckeown M J Makelg S Brown G G Jung T P Kinderman S S Bell A J and Sejnowski T J | 1998 | Human Brain Mapping1998，6，： | 1 |
| 9 | A physicochemical study of the aging of colloidal sillica gels used in zeolite Y synthesis显示文摘 | Ginter D M Went G T Bell A T | 1992 | Zeolites1992，12，： | 1 |
| 10 | Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins显示文摘 | Jantzen H M Admon A Bell S P | 1990 | Nature1990，344，： | 1 |
| 11 | Delta opioid receptor stimulation mimics ischemic preconditioning in human heart muscle显示文摘 | BELL S P SACK M N PATEL A | 2000 | J Am Coll Cardiol2000，36，7： | 1 |
| 12 | Peritoneal implants of o- varian serous borderline tumors: histologie features and prognosis 显示文摘 | Bell D A Weinstock M A Scully R E | 1988 | Cancer1988，62，10： | 1 |
| 13 | Depression biases the recognition of emotionally neutral faces显示文摘 | Lepp(a)nen JM Milders M Bell JS | 2004 | Psychiat Res2004，128，2： | 1 |
| 14 | Planning the use of fish for food security in the Pacific显示文摘 | Bell J D Kronen M Vunisea A | 2009 | Marine Policy2009，，： | 1 |
| 15 | NF-κB is activated during acute inflammation in vivo in association with molecule gene expression and leukocyte recruitment显示文摘 | BELL F P ROSENBLOOM J G | 1995 | J Inflamm1995，45，4： | 1 |
| 16 | Weight gain and its predictors in Chinese adults 显示文摘 | BELL A C GE K POPKIN B M | 2001 | Int J Obsity2001，25，： | 1 |
| 17 | Effect of Safflower Oil, Flaxseed Oil, Monensin, and Vitamin E on Concentration of Conjugated Linoleic Acid in Bovine Milk Fat 显示文摘 | BELL J A GRIINARI J M KENNELLY J j | 2006 | J Dairy Sci2006，89，2： | 1 |
| 18 | Functions of sphingolipids and sphingolipid breakdown products in cellular regulation显示文摘 | HANNUN Y A BELL R M | 1989 | Science1989，243，4890： | 1 |
| 19 | Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage显示文摘 | TAIT M J SAADOUN S BELL B A etal | 2010 | Neuroscience2010，167，1： | 1 |
| 20 | Technology Spillovers from Foreign Direct Investment FDI:An Exploration of the Active Role of MNC Subsidiaries in the Case of Argentina in the 1990s' 显示文摘 | MARIN A M BELL | 2006 | Journal of Development Studies2006，，42： | 1 |
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