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67篇 您的检索式:作者名="BENOS A"
    题名 作者 年代 出处 被引量
1Modeling of Multiple Liner Containment Systems for High Speed Rotors显示文摘 Beno J H Thompson R C 1999IEEE Transactions on Magnetics1999,35,1:1
2Extending the merton model: A hybrid approach to assessing credit quality显示文摘Benos A Papanastasopoulos G 2007Mathemati- cal and Computer Modelling2007,46,2:1
3Aggressiveness and Survival of Overconfident Traders显示文摘Benos A 1998J Financ Markets1998,,1:1
4Development of an individual treebased mechanical model to predict wind damage within forest stands显示文摘Philippe A Benot C Thierry F 2004Forest Ecology and Management2004,203,13:1
5Flywheel batteries come around again 显示文摘Hebner R Beno J Walls A 2002IEEE Spectr2002,39,4:1
6Flywheel batteries come around again显示文摘Hebner R Beno J Walls A 2002IEEE Spectrum2002,39,4:1
7Treatment of reconstituted textile wastewater containing a reactive dye in an aerobic sequencing batch reactor using a novel bacterial consortium显示文摘Imen K Beno M Raja B A 2012Separation and Purification Technology2012,87,:1
8Oxygen Ordering and the Orthorhombic-to-Tetragonal Phase Transition in YBa2Cu3O7-x显示文摘Jorgensen J D Beno M A Hinks D G 0,,:1
9Aggressiveness and survival of overconfident traders显示文摘Benos A 1998Journal of Financial Markets1998,20,1:1
10Oxygen Ordering and the Orthorhombic-to-tetragonal Phase Transition in YBa2Cu3O7-x 显示文摘Jorgensen J D Beno M A Hinks D G 1987Physical Review B1987,36,:1
11Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH.Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet 2022Bone Research2022,10,1:1
12Growth inhibition of Candida albicans hyphae by CD8^+ lymphocytes显示文摘BENO D W STOVER A G MATHEWS H L 1995J Immunol1995,54,10:1
13Electric ship power system integration analyses through modeling and simulation显示文摘OUROUA A DOMASCHK L BENO J H 2005Electric Ship Technologies Symposium2005,,:1
14Flywheel batteries come around again显示文摘Hebner R Beno J Walls A 2002IEEESpectrtma2002,39,4:1
15Suppression of stellate cell type I collagen gene expression involves AP-2 transmodulation of nuclear factor-1 -dependent gene transcription 显示文摘CHEN A P BENO D W A DAVIS B H 1996J Biol Chem1996,271,25:1
16Online remeshing for soft tissue sim- ulation in surgical training 显示文摘Paloc C Faraci A Beno F 2006IEEE Computer Graphics and Applications2006,26,6:1
17Aggressiveness and survival of overconfident traders显示文摘Benos A 1998Journal of Financial Markets1998,1,:1
18Aggressivess and Survival of Overconfident Traders 显示文摘Benos A 1998Journal of Financial Markets1998,,1:1
19Aggressiveness and survival of overconfident traders显示文摘Benos A 1998Journal of Financial Markets1998,1,:1
20Aggressiveness and survival of overconfident traders 显示文摘Benos A 1998Journal of Financial Markets1998,,1:1
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