|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 使用超高效液相色谱ACQUITY UPLC快速分析醛酮类化合物显示文摘 | Mark E Benvenuti | 2008 | 环境化学2008，27，4： | 9 |
| 2 | Constipation,deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alphasynucleinopathy显示文摘Background:Gastrointestinal dysfunction can affect Parkinson’s disease(PD)patients long before the onset of motor symptoms.However,little is known about the relationship between gastrointestinal abnormalities and the development of PD.Contrary to other animal models,the human A53T alpha-synuclein(αS)transgenic mice,Line G2–3,developsαS-driven neurological and motor impairments after 9 months of age,displaying a long presymptomatic phase free of central nervous system(CNS)dysfunction.Methods:To determine whether this line can be suitable to study constipation as it occurs in prodromal PD,gastrointestinal functionality was assessed in young mice through a multidisciplinary approach,based on behavioral and biochemical analysis combined with electrophysiological recordings of mouse intestinal preparations.Results:We found that the A53TαS mice display remarkable signs of gastrointestinal dysfunction that precede motor abnormalities andαS pathology in the CNS by at least 6 months.YoungαS mice show a drastic delay in food transit along the gastrointestinal tract,of almost 2 h in 3 months old mice that increased to more than 3 h at 6 months.Such impairment was associated with abnormal formation of stools that resulted in less abundant but longer pellets excreted,suggesting a deficit in the intestinal peristalsis.In agreement with this,electrically evoked contractions of the colon,but not of the ileum,showed a reduced motor response in both longitudinal and circular muscle layers inαS mice already at 3 months of age,that was mainly due to an impaired cholinergic transmission of the underlying enteric nervous system.Interestingly,the presence of insoluble and aggregatedαS was found in enteric neurons in both myenteric and submucosal plexi only in the colon of 3 months oldαS mice,but not in the small intestine,and exacerbated with age,mimicking the increase in transit delay and the contraction deficit showed by behavioral and electrical recordings data.Conclusions:Gastrointestinal dysfunction in A53TαS mice represents an early sign ofαS-driven pathology without concomitant CNS involvement.We believe that this model can be very useful to study disease-modifying strategies that could extend the prodromal phase of PD and haltαS pathology from reaching the brain. | Lucia Rota Carolina Pellegrini Laura Benvenuti Luca Antonioli Matteo Fornai Corrado Blandizzi Antonino Cattaneo Emanuela Colla | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 3 | Monitoring land degradation at national level using satellite Earth Observation time-series data to support SDG15-exploring the potential of data cube显示文摘Avoiding,reducing,and reversing land degradation and restoring degraded land is an urgent priority to protect the biodiversity and ecosystem services that are vital to life on Earth.To halt and reverse the current trends in land degradation,there is an immediate need to enhance national capacities to undertake quantitative assessments and mapping of their degraded lands,as required by the Sustainable Development Goals(SDGs),in particular,the SDG indicator 15.3.1(“proportion of land that is degraded over total land area”).Earth Observations(EO)can play an important role both for generating this indicator as well as complementing or enhancing national official data sources.Implementations like Trends.Earth to monitor land degradation in accordance with the SDG15.3.1 rely on default datasets of coarse spatial resolution provided by MODIS or AVHRR.Consequently,there is a need to develop methodologies to benefit from medium to high-resolution satellite EO data(e.g.Landsat or Sentinels).In response to this issue,this paper presents an initial overview of an innovative approach to monitor land degradation at the national scale in compliance with the SDG15.3.1 indicator using Landsat observations using a data cube but further work is required to improve the calculation of the three sub-indicators. | Gregory Giuliani Bruno Chatenoux Antonio Benvenuti Pierre Lacroix Mattia Santoro Paolo Mazzetti | 2020 | Big Earth Data2020，4，1： | 4 |
| 4 | Synthesis and activity of a new series of chalcone as aldose reductase inhibitors 显示文摘 | Severi F Benvenuti S Costantino L | 1998 | Eur J Med Chem1998，33，11： | 1 |
| 5 | Clinical value of calcifications in thyroid carcinoma and multinodular goiter显示文摘 | Consorti F Anello A Benvenuti C | 2003 | Anticaner Res2003，23，3： | 1 |
| 6 | Intermittent high glucose concentrations reduce neuronal precursor survival by altering the IGF system:the involvement of the neuroprotective factor DHCR24(Seladin-1)显示文摘 | Giannini S Benvenuti S Luciani P | 2008 | J Endocrinol2008，198，3： | 1 |
| 7 | Gene copy num- ber for epidermal growth factor receptor(EGFR)and clin- ical response to anti-EGFR treatment in colorectal cancer:a cohort study显示文摘 | Moroni M Veronese S Benvenuti S | 2005 | Lancet Oncol2005，6，5： | 1 |
| 8 | Tracking a Ballistic Target: Comparison of Several Nonlinear Filters显示文摘 | FARINA A RISTIC B BENVENUTI D | 2002 | IEEE Trans on Aerospace and Electronic Systems2002，38，3： | 1 |
| 9 | Anterior cervical corpectomy for cervical spondylotic myelopathy: experience and surgical results in a series of 70 consecutive patients 显示文摘 | Chibbaro S Benvenuti L Carnesecchi S | 2006 | J Clin Neurosci2006，13，2： | 1 |
| 10 | Clinical signifi-cance of thyroid nodule calcification显示文摘 | Consorti F Benvenuti C | 2003 | G Chir2003，24，3： | 1 |
| 11 | Clinical value of calcification in thyroid carcinoma and multinodular goiter显示文摘 | Consorti F Anello A Benvenuti C | 2003 | Anticancer Rer2003，23，3： | 1 |
| 12 | Vacuum显示文摘 | Benvenuti C Cazeneuve J M Chiggiato P | 1999 | 53(1-2) :219 - 2251999，53，12： | 1 |
| 13 | Auto- motive engine control and hybrid systems: challen- ges and opportunities显示文摘 | Balluchi A Benvenuti L Di Benedetto | 2000 | Proceedings of the IEEE2000，88，7： | 1 |
| 14 | A Novel Route to Extreme Vacuum:the Non-Evaporable Getter Thin Film Coatings显示文摘 | Benvenuti C Cazeneuve J M Chiggiato P | 1999 | Vacuum1999，53，： | 1 |
| 15 | Tracking a ballistic tar-get: comparison of severalnonlinear filters 显示文摘 | Frina A Ristic B Benvenuti D | 2002 | IEEETransactions on Aerospace and Electronic Systems2002，38，3： | 1 |
| 16 | Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti - epider- mal growth factor receptor antibody therapies 显示文摘 | Benvenuti S Sartore - Bianchi A Di NF | 2007 | Cancer Res2007，67，： | 1 |
| 17 | Community- based exercise for upper limb paresis: a controlled trial with telerehabilitation显示文摘 | Benvenuti F Stuart M Cappena V | 2014 | Neurorehabil Neural Repair2014，28，7： | 1 |
| 18 | Electronic switching in phase change memories 显示文摘 | Pirovano A Lacaita A L Benvenuti A | 2004 | IEEE Transactions on Electron Devices2004，51，： | 1 |
| 19 | Light, temperature and buri al depth effects on Rumez obtussifolius seed germination and emergence显示文摘 | Benvenuti S Macchia M Miele S | 2001 | Weed Research2001，41，： | 1 |
| 20 | Schwannomas of the brachlal plexus-diagnostic and surgical problems显示文摘 | Maiuri F Donzelli R Benvenuti D | 2001 | Zentralbl Neurochit2001，62，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员