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| 1 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 2 | Effect of low addition rates of polypropylene fibers on plastic shrinkage cracking and mechanical properties of concrete 显示文摘 | Berke N S Dallaire M P | 1994 | American Concrete Institute Farmington Hills1994，142，： | 1 |
| 3 | Epithelial differentiation of adipose-derived stem cells for laryngeal tissue engineering显示文摘 | Long JL Zuk P Berke GS | 2010 | Laryngoscope2010，120，1： | 1 |
| 4 | Comparison of Er,Cr:YS- GG laser and hand instrumentation on the attachment of periodontal ligament fibroblasts to periodontally diseased root surfaces: an in vitro study 显示文摘 | Hakki S S Korkusuz P Berk G | 2010 | J Periodontol2010，81，8： | 1 |
| 5 | Remote bathymetry of the littoral zone from AVIRIS,LASH,and quickbird imagery显示文摘 | ADLER-GOLDEN S M ACHARYA P K BERK A | 2005 | IEEE Transactions on Geoscience and Remote Sensing2005，43，2： | 1 |
| 6 | The influence of state planning mandates on local plan quality显示文摘 | BERKE P R FRENCH S P | 1994 | Journal of Planning Education and Research1994，，13： | 1 |
| 7 | Comparison of Er, Cr: YSGG laser and hand instrumentation on the attachment of periodontal ligament fibroblasts to periodontally diseased root surfaces: an in vitro study显示文摘 | Hakki SS Korkusuz P Berk G | 2010 | J Periodontol2010，81，8： | 1 |
| 8 | Comorbid depression and health-related quality of life in patients with coronary artery disease显示文摘 | Stafford L Berk M Reddy P | 2007 | J Psychosom Res2007，62，4： | 1 |
| 9 | Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilinA 显示文摘 | SATOH K NIGM P BERK B C | 2010 | Antioxid Redox signal2010，12，5： | 1 |
| 10 | Grundlagen der Finanzwirtschaft Analyse,Entscheidung und Umsetzung显示文摘 | Berk J Demarzo P | 2011 | München2011，，： | 1 |
| 11 | Public participation in local government review of development proposals in Hazardous Locations:Does it matter,and what do local government planners have to do with it?显示文摘 | STEVENS M R BERKE P R YAN S | 2010 | Environmental Management2010，45，2： | 1 |
| 12 | Regulation of sodium-hydrogen exchange in vascular smooth muscle显示文摘 | Lucchesi P A Berk B C | 1995 | Cardiovasc Res1995，29，2： | 1 |
| 13 | Emotion regulation and mental health : Re- cent findings, current challenges, and future directions 显示文摘 | Berking M Wupperman P | 2012 | Current Opinion in Psychiatry2012，25，2： | 1 |
| 14 | Remote ba- thymetry of the littoral zone from AVIRIS, LASH, and Quick- Bird imagery显示文摘 | Adler-Golden S M Acharya P K Berk A | 2005 | IEEE Transactions on Geoscience and Remote Sensing2005，43，2： | 1 |
| 15 | Pretend and physical play : Links to preschoolers' affective social competence 显示文摘 | Lindsey E W Berks P S & Colwell M J | 2013 | Mer- rill-Palmer Quarterly2013，59，3： | 1 |
| 16 | Spliced early mRNAs of simian virus 40显示文摘 | BERK A J SHARP P A | 1978 | Natl Acad Sci U S A1978，75，3： | 1 |
| 17 | What Makes Plan Implementation Successful? An Evaluation of Local Plans and Implementation Practices in New Zealand显示文摘 | Berke P Backhurst M Day M Ericksen N Laurian L Crawford J Dixon J | | 0，，04： | 1 |
| 18 | The mechanism of the catalytic oxidation of hydrogen sulfide 显示文摘 | Steijins M Berks F Verloop A Mars P | 1976 | J Catal1976，42，： | 1 |
| 19 | Thoughts about the efforts for the elimination of Labour pain and the application of epidural analgesia in obstetrics显示文摘 | Berk P | 2005 | Orv Hetil2005，146，43： | 1 |
| 20 | Adaptive comanagement for building resilience in social-ecological systems 显示文摘 | Olsson P Folke C Berkes F | 2004 | Environmental Management2004，34，1： | 1 |
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