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| 1 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 2 | Pregnancy outcome in long-term survivors ofchildhood cancer显示文摘 | Blatt J | 1999 | Med Pediatr Oncol1999，33，9： | 1 |
| 3 | The effect of repeated heat and cold exposureon serum protein composition in man 显示文摘 | Blatt WF Kerkay J | 1967 | Can J Physiol Pharma-col1967，45，4： | 1 |
| 4 | Interpersonal relatedness, self-definition, and their motivational orientation during adolescence: A heorical and empirical integration显示文摘 | Shahar Golan Henrich Christopher C Blatt Sidney j | 2003 | Developmental Psychology2003，39，3： | 1 |
| 5 | Basal core promoter T1762/ A1764 and precore A 1896 gene mutations in hepatitis B surface antigen - positive hepatocellular carcinoma: a comparison with chronic carriers 显示文摘 | Tong M J Blatt L M Kao J H | 2007 | Liver Int2007，27，10： | 1 |
| 6 | Pregnancy outcome in long-term survivors of childhood cancer显示文摘 | Blatt J | | 0，，01： | 1 |
| 7 | Effects of Energy Content and Energy Density of Pre-Portioned Entrees on Energy Intake 显示文摘 | Blatt A D Williams R A Roe L S Rolls B J | 2012 | Obesity2012，20，10： | 1 |
| 8 | Functional conservation between yeast and plant endosomal Na+/H+ antiporter显示文摘 | Quintero F J Blatt M R Pardo J M | 2000 | FEBS Lett2000，47，1： | 1 |
| 9 | Reflections on the Looking Glass:A Review of Research on Feedback-seeking Behavior in Organizations显示文摘 | Ashford S J Blatt R Walle D V | 2003 | Journal of Management2003，29，6： | 1 |
| 10 | The destructiveness of perfectionism:Implications for the treatment of depression显示文摘 | Blatt S J | | American Psychologist0，，： | 1 |
| 11 | Dark squeezed states of the motion of a trapped ion 显示文摘 | Cirac J I Parkins A S Blatt R etc | 1993 | Phys Rev Lett1993，，70： | 1 |
| 12 | Prediction of response during interferon alfa 2b therapy in chronic hepatitis C patients using viral and biochemical characteristics:a comparison显示文摘 | Tong M J Blatt LM McHutchison JG Co RL Courad A | | Hepatology0，，： | 1 |
| 13 | Monolithic Fourier-transform imaging spectrometer显示文摘 | RAFFART B J SELLAR G R BLATT H J | 1995 | Appl Opt1995，34，： | 1 |
| 14 | 'Dark' squeezed states of montion of a trappedion显示文摘 | Circ J I Parkins A S Blatt R | 1993 | Phys Rev Lett1993，70，： | 1 |
| 15 | The biologic activity and molecular characterization of a novel synthetic interferon-alpha species, consensus interferon显示文摘 | Blatt L M Davis J M Klein S B | 1996 | Journal of International Cytometry Research1996，16，： | 1 |
| 16 | Monolithic Fourier transform imaging spectrometer 显示文摘 | Rafert J B Sellar R G Blatt J H | 1995 | Appl Opt1995，34，31： | 1 |
| 17 | Childhood Non-Hodgkin lymphoma presenting as hemophagocytic syndrome显示文摘 | Blatt J Weston B Belhorn T | | 0，，： | 1 |
| 18 | Punctual and Procrastinating students: A study of temporal parameters 显示文摘 | Blatt S J Quinn P | 1967 | Journal of Consulting Psychology1967，31，： | 1 |
| 19 | Monolithic Fouriertransform imaging spectrometer显示文摘 | RAFERT J B SELLER R G BLATT J H | 1995 | Appl Opt1995，34，31： | 1 |
| 20 | Functional conservation between Yeast and plant endosomal Na^+/H^+ antiporters显示文摘 | Quintero F J Blatt M R Pardo J M | 2000 | FEBS Lett2000，471，： | 1 |
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