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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	Re cent sedimentation and sediment accumulation rates of the Ba Lat prodelta(Red River, Vietnam) 显示文摘	van den Bergh G D Boer W Schaapveld M A S	2007	Journal of Asian Earth Sciences2007，，29：	1
3	Reperfusion therapy in elderly patients with acute myocardial infarction: a randomized comparison of primary angioplasty and thrombolytic therapy 显示文摘	de Boer M J Ottervanger J P vant Hof A W	2002	J Am Coil Cardiol2002，39，11：	1
4	High volume haemofiltration and hybrid techniques in sepsis:new insights into the rationale显示文摘	Honor P M Boer W Joannes B O	2007	Neth J Crit Care2007，11，：	1
5	Characteristic stroke mechanics of elite and trained male speed sksyrtd 显示文摘	Boer R W Paul Schermerhorn Groot G	1986	Sport Biomechanics1986，2，：	1
6	Quality of life in patients with Parkinson's disease:development of a questionnaire显示文摘	Boer AG Wijker W Speelman JD	1996	J Neurol Neurosurg Psychiatry1996，61，：	1
7	Analysis of ammonia-oxidizing bacteria of the 13 subdivision of the class Pro- teobacteria in coastal sand dunes by denaturing gradient gel electro- pboresis and sequencing of PCR-amplified 16S ribosomal DNA frag- ments 显示文摘	KOWALCHUK G A STEPHEN J R DE BOER W	1997	Appl Environ Microbiol1997，63，4：	1
8	Nitrification in acid soils: microorganisms and mechanisms显示文摘	De Boer W Kowalchuk G A	2001	Soil Biol Biochem2001，33，：	1
9	Microbial community composition affects soil fungistasis显示文摘	De Boer W Verheggen P Klein Gunnewiek P J A	2003	Appl Environ Microbiol2003，69，：	1
10	Co-evolution of firm absorptive capacity and knowledge environment:organizational forms and combinative capabilities显示文摘	BOSCH F A J V VOLBERDA H W BOER M D	1999	Organization Science1999，10，5：	1
11	The reduction and 0xidation behavior of manganese oxides显示文摘	de Boer B A Geuis J W	1999	Catal Today1999，47，：	1
12	Coevolution of finn absorptive capacity and knowledge environment: Organizational forms and combinative capabilities 显示文摘	VAN AJ DEN BOSCH HENK W VOLBERDA MICHIELDE BOER	1999	Organization Science Linthicum: Sep/Oct1999，10，5：	1
13	Telomere biology in healthy aging and disease显示文摘	Oeseburg H de Boer R A van Gilst W H van der Harst P	2010	Pflugers Arch2010，459，：	1
14	Legionnaires' disease and Pontiac fever after using a private outdoor whirlpool spa 显示文摘	Euser S M Pelgrim M den Boer J W	2010	Scand J Infect Dis2010，42，：	1
15	Managing organizational knowledge integration in the emerging multimedia complex 显示文摘	De Boer M Van den Bosch Frans A J Volberda H W	1999	Journal of Management Studies1999，36，3：	1
16	Collagen synthesis by human liver (myo) fibroblasts in culture:evidence for a regulatory role of IL-1 beta,IL-4,TGF beta and IFN gamma显示文摘	Tiggelman AM Boers W Linthorst C	1995	J Hepatol1995，23，3：	1
17	Apolipoprotein A-V:a novel apolipoprotein associated with an early phase of liver regeneration显示文摘	Van der Vliet HN Sammelsm MG Leegwater AC Levels JH Reitsma PH Boers W	2001	J Biol Chem2001，276，44：	1
18	Phylogeny-function analysis of (meta)genomic libraries: screening for expression of ribosomal RNA genes by large-insert library fluorescent in situ hybridisation (LIL-FISH) 显示文摘	Leveau J H J Gerards S de Boer W	2004	Environ Microbiol2004，6，9：	1
19	One-dimensional transient wave propagation in fluid-saturated incompressible porous media 显示文摘	DE BOER R EHLERS W LIU Z	1993	Archive of Applied Mechanics1993，63，：	1
20	Co-evolution of Firm Absorptive Capacity and Knowledge Environment: Organizational Forms and Combinative Capabilities显示文摘	BoschF A J V D Volberda H W Boer M D	1999	ERIM Top-Core Articles1999，10，5：	1

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