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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 3 | Expression of bcl-2, c-erbB- 2, p53, and p21 (waf1 -cip1) protein in thyroid carcinomas 显示文摘 | Soda G Antonaci A Bosco D | 1999 | J Exp Clin Cancer Res1999，18，3： | 1 |
| 4 | A clinical variant of familial Hermansky-Pudlak syndrome显示文摘 | Iannello S Fabbri G Bosco P | 2003 | Med Gen Med2003，5，1： | 1 |
| 5 | Sophisticated spinal contributions to motor control显示文摘 | Poppele R Bosco G | 2003 | Trends Neurosci2003，26，5： | 1 |
| 6 | Zn (ClO4) · 6H2O as a powerful catalyst for the conversion of β-ketoesters into β-enamino esters 显示文摘 | BARTOLI G BOSCO M LOCATELLI M | 2004 | Synlett2004，，2： | 1 |
| 7 | Lower apoptosis rate in human cumulus cells after administration of recombinant luteinizing hormone to women undergoing ovarian stimulation for in vitro fertilization procedures显示文摘 | Ruvolo G Bosco L Pane A | 2007 | Fertil Steril2007，87，3： | 1 |
| 8 | Agerelated disability in multiple sclerosis显示文摘 | Trojano M Liguori M Bosco Zimatore G | 2002 | Ann Neurol2002，51，4： | 1 |
| 9 | Lens fiber transdifferen-tiation in cultured larval Xenopus leavis out cornea under the influence of neural retina-conditioned medium 显示文摘 | Bosco L Testa O Venturini G Willems D | 1997 | Cell Mol Life Sci1997，53，1112： | 1 |
| 10 | Hippoeampal cellular loss after brief hypotension 显示文摘 | Chaparro RE Quiroga C Bosco G et at | 2013 | Springerplus2013，2，1： | 1 |
| 11 | Plant growth-promoting Pseudomonas putida WCS358 produces and secretes four cyclic dipeptides: cross-talk with quorum sensing bacterial sensors显示文摘 | Degrassi G Aguilar C Bosco M | 2002 | Current Microbiology2002，45，4： | 1 |
| 12 | A posteriori error estimates for fully discrete nonlinear parabolic problems显示文摘 | Javier F Bosco G A Julia N | 2007 | Comput Methods Appl Mech Engrg2007，196，： | 1 |
| 13 | Soft decoding in optical systems 显示文摘 | Bosco G Montorsi G Benedetto S | 2003 | IEEE Transactions on Communications2003，51，8： | 1 |
| 14 | The effect of pre-stretch on mechanical efficiency of human skeletal muscle显示文摘 | BOSCO C MONTANARI G TARKKA I | 1987 | Acta Physiol Scand1987，131，： | 1 |
| 15 | Neurokinin 1 receptor expression and substance P physiological actions are developmentally regulated in the rabbit retina显示文摘 | Casini G Dal Monte M Fornai F Bosco L Willems D Yang Q | 2004 | Neuroscience2004，124，1： | 1 |
| 16 | Magnesium perchlorate as efficient Lewis acid for the Knoevenagel conden- sation between 13-diketones and aldehydes 显示文摘 | BARTOLI G BOSCO M CARLONE A | 2008 | Tetrahedron Letters2008，49，16： | 1 |
| 17 | A large aperture electro-optic deflector显示文摘 | BOSCO A BOOGERT S T BOORMAN G E | 2009 | Applied Physics Letters2009，94，21： | 1 |
| 18 | Posterior lumbar fusion by peek rods in degenerative spine preliminary report on 30 cases显示文摘 | F De Iure G Bosco M Cappuccio | 2012 | EurSpineJ2012，，1： | 1 |
| 19 | Modeling of the impact of nonlinear propagation effects in uncompensated optical coherent transmission links 显示文摘 | Carena A Ourri V Bosco G | 2012 | Journal of Lightwave Technology2012，30，10： | 1 |
| 20 | Association of IL-1 RN * 2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease显示文摘 | Bosco P Gueant Rodriguez RM Anello G | 2004 | J Neurosurg Psychiatry2004，75，7： | 1 |
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