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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 3 | Controlled-release oxycodone tablets after transdermal-based opioid therapy in patients with cancer and non-cancer pain显示文摘 | Ravera E Di Santo S Bosco R | 2011 | Aging Clin Exp Res2011，23，56： | 1 |
| 4 | Metformin and incident breast cancer among diabetic women:a population-based case-control study in Denmark显示文摘 | Bosco JL Antousen S S(o)rensen HT | | 0，，01： | 1 |
| 5 | A clinical variant of familial Hermansky-Pudlak syndrome显示文摘 | Iannello S Fabbri G Bosco P | 2003 | Med Gen Med2003，5，1： | 1 |
| 6 | Hypoxic synovial environment and expression of macrophage inflammatory protein 3gamma/ CCL20 in juvenile idiopathic arthritis 显示文摘 | Bosco MC Delfino S Ferlito F | 2008 | Arthritis Rheum2008，58，6： | 1 |
| 7 | Low temperature hydrogenation of benzene and cyclohexene:A comparativestudy between γ-Al2O3 supported Pt-Co and Pt-Ni bimetallic catalysts显示文摘 | Lu S L Lonergan W W Bosco J P | | 0，，259： | 1 |
| 8 | Soft decoding in optical systems 显示文摘 | Bosco G Montorsi G Benedetto S | 2003 | IEEE Transactions on Communications2003，51，8： | 1 |
| 9 | Liver splenosis mimicking hepatocellular carcinoma in cirrhotic liver显示文摘 | Levi Sandri GB Lai Q Bosco S | 2014 | Liver Int2014，34，1： | 1 |
| 10 | A large aperture electro-optic deflector显示文摘 | BOSCO A BOOGERT S T BOORMAN G E | 2009 | Applied Physics Letters2009，94，21： | 1 |
| 11 | Audiogenic seizures susceptibility in transgemic mice with fragile X syndrome 显示文摘 | Musumeci S A Bosco P Colabrese G | 2000 | Epilepsia2000，41，： | 1 |
| 12 | Pharmacokinet- ics of a novel submicron budesonide dispersion for nebulized de- livery in asthma 显示文摘 | SHREWSBURY S B BOSCO A P USTER P S | 2009 | Int J Pharm2009，365，12： | 1 |
| 13 | Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A显示文摘 | Bosco DA Eisenmesser EZ Pochapsky S | | 0，，： | 1 |
| 14 | Metformin and incident breast cancer among diabetic women:a population-based case-control study in Denmark显示文摘 | Bosco JL Antonsen S Sorensen HT | 2011 | Cancer Epidemiol Biomarkers Prey2011，20，1： | 1 |
| 15 | The tryptophan catabolite picolinic acid selectively in- duces the chemokines macrophage inflammatory pro- tein-la and -113 in macrophages显示文摘 | BOSCO M C RAPISARDA A MASSAZZA S | 2000 | The Journal of Im- munology2000，164，： | 1 |
| 16 | A Nationwide Comparison of Driving Distance Versus Straight-Line Distance to Hospitals显示文摘 | Boscoe F P Henry K A Zdeb M S | 2012 | The Professional Geographer2012，64，20： | 1 |
| 17 | Dexmedetomidine for anterior mediastinal mass computed tomography-guided biopsy: a case series显示文摘 | Carollo D S Pestieau S Bosco R | 2013 | The Ochsuer Journal2013，13，4： | 1 |
| 18 | Use of a La(Ⅲ)- modified bentonite for effective phosphate removal from aqueous media 显示文摘 | KurokiV Bosco G E Fadini P S | 2014 | Journal of Hazardous Materials2014，274，： | 1 |
| 19 | Dexmedetomidine for anterior mediastinal mass computed tomography-guided biopsy : a case series 显示文摘 | Carollo D S Pestieau S Bosco R | 2013 | The Oehsner Journal2013，13，4： | 1 |
| 20 | A large aperture electro-optic deflector 显示文摘 | BOSCO A BOOGERT S T BOORMAN G E | 2009 | Applied Physics Letters2009，94，21： | 1 |
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