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| 1 | Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy显示文摘AIM: To examine DNA methylation profiles in a longitudinal comparison of pre-diabetes mellitus(Pre-DM) subjects who transitioned to type 2 diabetes mellitus(T2DM).METHODS: We performed DNA methylation study in bisulphite converted DNA from Pre-DM(n = 11) at baseline and at their transition to T2 DM using Illumina Infinium Human Methylation27 Bead Chip, that enables the query of 27578 individual cytosines at Cp G loci throughout the genome, which are focused on the promoter regions of 14495 genes.RESULTS: There were 694 Cp G sites hypomethylated and 174 Cp G sites hypermethylated in progression from Pre-DM to T2 DM, representing putative genes involved in glucose and fructose metabolism, inflammation, oxidative and mitochondrial stress, and fatty acid metabolism. These results suggest that this high throughput platform is able to identify hundreds of prospective Cp G sites associated with diverse genes that may reflect differences in Pre-DM compared with T2 DM. In addition, there were Cp G hypomethylation changes associated with a number of genes that may be associated with development of complications of diabetes, such as nephropathy. These hypomethylation changes were observed in all of the subjects.CONCLUSION: These data suggest that some epigenomic changes that may be involved in the progression of diabetes and/or the development of complications may be apparent at the Pre-DM state or during the transition to diabetes. Hypomethylation of a number of genes related to kidney function may be an early marker for developing diabetic nephropathy. | Thomas A Vander Jagt Monica H Neugebauer Marilee Morgan Donald W Bowden Vallabh O Shah | 2015 | World Journal of Diabetes2015，6，9： | 5 |
| 2 | Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways显示文摘 | Galloway W R J D Hodgkinson J T Bowden S D | 2010 | Chem Rev2010，111，1： | 1 |
| 3 | Altered imprinted gene methylation and expression in completely ES cell derived mouse fetuses: association with aberrant phenotypes 显示文摘 | Dean W Bowden L Aitchison A | 1998 | Development1998，125，12： | 1 |
| 4 | Tech- niques of PIV in stratified two-phase headers显示文摘 | SALEH W BOWDEN R C HASSAN I G | 2010 | Experi- mental Thermal and Fluid Science2010，35，1： | 1 |
| 5 | Identification of a mu tation in Dlx3 associated with tricho dento-osseous (TDO) syn drome显示文摘 | Price J A Bowden D W Wright J T | 1998 | Human Molecular Genetics1998，7，3： | 1 |
| 6 | Gaseous nitrogen emissions from undisturbed terrestrial ecosystems: an assessment of their impacts on local and global nitrogen budgets显示文摘 | BOWDEN W B | 1986 | Biogeochemistry1986，2，： | 1 |
| 7 | RGS6 va- riants are associated with dietary fat intake in Hispanics: the IRAS Family Study显示文摘 | SIBBEL S P TALBERT M E BOWDEN D W | 2011 | Obesity (Silver Spring)2011，19，7： | 1 |
| 8 | WISARD a radical step forward in image recognition显示文摘 | THOMAS W V,BOWDEN P A | 1984 | Sensor Review1984，4，3： | 1 |
| 9 | The biogeochemistry of nitrogen in freshwater wetlands 显示文摘 | | 1987 | Biogeochemistry1987，4，： | 1 |
| 10 | Stability of lithium ion spinel cells Ⅲ improved life of charged cells显示文摘 | Wang E Ofer D Bowden W | 2000 | J Electrochem Soc2000，147，11： | 1 |
| 11 | A New, Low-Temperature Polymorph of O'-SiA1ON显示文摘 | Bowden M E Barris G C Brown I W M | 1998 | Journal of the American Ceramic Society1998，81，8： | 1 |
| 12 | Concurrent verbalizations, pedagogical conditions, and reactivity: Two CALL studies 显示文摘 | Sanz C Lin H-J Lado B Bowden H W & Stafford C A | 2009 | Language Learning2009，，1： | 1 |
| 13 | Chromosome number in seven genera of the tribe Triticeae显示文摘 | Bowden W M | 1966 | Can J Genet Cytol1966，，8： | 1 |
| 14 | Multi-variable and multi-site calibration and validation of SWAT in a large mountainous catchment with high spatial variability显示文摘 | CAO Wen-zhi BOWDEN B W DAVIE T | 2006 | Hydrological Processes2006，20，5： | 1 |
| 15 | Nitrification, nitrate reduction, and nitrogen immobilization in a tidal freshwater marsh sediment显示文摘 | Bowden W B | 1986 | Ecology1986，67，： | 1 |
| 16 | The hydraulic characteristics and geochemistry of hyporheic and parafluvial zones in Arctic tundra streams, north slope,Alaska显示文摘 | Edwardson K J Bowden W B Dahm C | 2003 | Ad vances in Water Resources2003，26，： | 1 |
| 17 | Modeling im- pacts of land cover change on critical water resources in the Motueka river catchment, New Zealand显示文摘 | Cao W Z Bowden W B Davie T | 2009 | Water Resources Management2009，23，1： | 1 |
| 18 | Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses association with aberrant phenotypes 显示文摘 | DEAN W BOWDEN L AITCHISON A | 1998 | Development1998，125，： | 1 |
| 19 | A mechanistic,numerical model of sedimentation,mineralization,and decomposition for marsh sediments显示文摘 | MORRIS J T BOWDEN W B | 1986 | Soil Society of America Journal1986，50，1： | 1 |
| 20 | Cognitive functioning in idio- pathic generalised epilepsies: a systematic review and meta-analysis 显示文摘 | Loughman A Bowden SC D' Souza W | 2014 | Neurosci Biobehav Rev2014，43，： | 1 |
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