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| 1 | Effects of intermittent fasting on health markers in those with type 2 diabetes:A pilot study显示文摘AIM To determine the short-term biochemical effects and clinical tolerability of intermittent fasting(IF) in adults with type 2 diabetes mellitus(T2DM).METHODS We describe a three-phase observational study(baseline 2 wk, intervention 2 wk, follow-up 2 wk) designed to determine the clinical, biochemical, and tolerability of IF in community-dwelling volunteer adults with T2DM. Biochemical, anthropometric, and physical activity measurements(using the Yale Physical Activity Survey) were taken at the end of each phase. Participants reported morning, afternoon and evening self-monitored blood glucose(SMBG) and fasting duration on a daily basis throughout all study stages, in addition to completing a remote food photography diary three times within each study phase. Fasting blood samples were collected on the final days of each study phase. RESULTS At baseline, the ten participants had a confirmed diagnosis of T2DM and were all taking metformin, and on average were obese [mean body mass index(BMI) 36.90 kg/m^2]. We report here that a short-term periodof IF in a small group of individuals with T2DM led to significant group decreases in weight(-1.395 kg, P = 0.009), BMI(-0.517, P = 0.013), and at-target morning glucose(SMBG). Although not a study requirement, all participants preferentially chose eating hours starting in the midafternoon. There was a significant increase(P < 0.001) in daily hours fasted in the IF phase(+5.22 h), although few attained the 18-20 h fasting goal(mean 16.82 ± 1.18). The increased fasting duration improved at-goal(< 7.0 mmol/L) morning SMBG to 34.1%, from a baseline of 13.8%. Ordinal Logistic Regression models revealed a positive relationship between the increase in hours fasted and fasting glucose reaching target values(χ~2 likelihood ratio = 8.36, P = 0.004) but not for afternoon or evening SMBG(all P > 0.1). Postprandial SMBGs were also improved during the IF phase, with 60.5% readings below 9.05 mmol/L, compared to 52.6% at baseline, and with less glucose variation. Neither insulin resistance(HOMAIR), nor inflammatory markers(C-reactive protein) normalized during the IF phase. IF led to an overall spontaneous decrease in caloric intake as measured by food photography(Remote Food Photography Method). The data demonstrated discernable trends during IF for lower energy, carbohydrate, and fat intake when compared to baseline. Physical activity, collected by a standardized measurement tool(Yale Physical Activity Survey), increased during the intervention phase and subsequently decreased in the follow-up phase. IF was well tolerated in the majority of individuals with 6/10 participants stating they would continue with the IF regimen after the completion of the study, in a full or modified capacity(i.e., every other day or reduced fasting hours).CONCLUSION The results from this pilot study indicate that shortterm daily IF may be a safe, tolerable, dietary intervention in T2DM patients that may improve key outcomes including body weight, fasting glucose and postprandial variability. These findings should be viewed as exploratory, and a larger, longer study is necessary to corroborate these findings. | Terra G Arnason Matthew W Bowen Kerry D Mansell | 2017 | World Journal of Diabetes2017，8，4： | 7 |
| 2 | Terahertz pulse imaging in archaeology显示文摘在这份报纸介绍的工作在芝加哥大学在东方研究所被执行,在从他们的永久收集的目标上:一具古老的埃及鸟木乃伊和三个古老的闪族语的侵蚀的铜合金目标。我们使用了便携式的、联合纤维的兆兆赫(THz ) 时间域分光镜的成像系统,它允许我们在传播和思考几何学测量标本,和基于时间、基于频率的现在想象模式。结果证实 THz 成像能提供互补信息给那的更早的证据从计算断层摄影术(XRCT ) 木乃伊扫描的 X 光检查可获得,给低密度区域的更好的可视化。另外,我们证明 THz 成像能在金属人工制品区分使矿物化的层。 | J. Bianca JACKSON Julien LABAUNE Rozenn BAILLEUL-LESUER Laura D'ALESSANDRO Alison WHYTE John W. BOWEN Michel MENU Gerard MOUROU | 2015 | Frontiers of Optoelectronics2015，8，1： | 3 |
| 3 | On the relationship between customer participation and satisfaction:Two frameworks显示文摘 | Kellogg D L Youngdahl W E Bowen D E | 1997 | International Journal of Service Industry Management1997，8，3： | 1 |
| 4 | Increased expression of GPI-specific phospholipase D in mouse models of type 1 diabetes显示文摘 | Deeq M A Bowen R F williams M D | 2001 | Am J Physiol Endocrinol Metab2001，281，： | 1 |
| 5 | Novel insecticidal toxins from the bacterinm Photorhabdus luminescens显示文摘 | Bowen D J Rochelean T A Blackburn M | 1998 | Science1998，6，： | 1 |
| 6 | Managing customers as human resources in service organizations 显示文摘 | Bowen D E | 1986 | Human Resource Management1986，，25： | 1 |
| 7 | Management theory and total quality: improving research and practice through theory development显示文摘 | DEAN J BOWEN D E | 1994 | The Academy of Management Review1994，19，3： | 1 |
| 8 | On the relationship between customer participation and satis-faction: two frameworks显示文摘 | KELLOGG D L YOUNGDAHL W E BOWEN D E | 1997 | International Journal of Service1997，8，3： | 1 |
| 9 | Germline and somatic transformation of mating Tetrahymena themtophila by particle bombardment显示文摘 | Cassidy-Hanley D Bowen J Lee J H | 1997 | Genetics1997，146，1： | 1 |
| 10 | Comparison of the clinical diagnosis of diabetic macular edema with diagnosis by optical coherence tomograpby显示文摘 | Browning D J Mcowen MD Bowen RM | | 0，，04： | 1 |
| 11 | Understanding HRM_ firm performance linkages:The role of the HRM system显示文摘 | Bowen D E and Ostroff C | | 0，，02： | 1 |
| 12 | Not Quite Paradise:Inadequacies of Environmental Impact Assessment in the Maldives显示文摘 | Zubair S Bowen D Elwin J | 2011 | Tourism Management2011，32，2： | 1 |
| 13 | Hiring for the Organization, Not the Job显示文摘 | Bowen D E Ledford G E Jr Nathan B R | 1991 | Ademy of Management Executive1991，5，4： | 1 |
| 14 | Antecedents of consumer satisfaction and dissatisfaction (CS/D) on long-haul inclusive tours-a reality check on theoretical considerations显示文摘 | Bowen D | 2001 | Tourism Management2001，，22： | 1 |
| 15 | Novel insecticidal toxins from the bacterium Photorhabdus luminescens显示文摘 | Bowen D J Rochelle T A Blackburn M | 1998 | Science1998，6，： | 1 |
| 16 | A framework for analyzing customer service orientations in manufac- turing显示文摘 | Bowen D E Siehl C Schneider B | 1998 | The Academy of Management Review1998，14，1： | 1 |
| 17 | Agrin acts via a MuSK receptor complex显示文摘 | Glass D J Bowen D C Stitt T N | 1996 | Cell1996，85，4： | 1 |
| 18 | Understanding HRM- Firm Performance Linkages:The Role of the 'Strength' of the HRM System显示文摘 | BOWEN D E OSTROFF C | 2004 | Academy of Management Review2004，29，2： | 1 |
| 19 | The effort of merroy-management policies on system reliability显示文摘 | BOWEN N S PRADHAN D K | 1993 | IEEE Transactions on Reliablity1993，42，3： | 1 |
| 20 | Thermoelectric Power Sensor for Microwave Applications by Commercial CMOS Fabrication显示文摘 | Gaitan M Bowen E D | 1997 | IEEE Electron Device Letters1997，18，9： | 1 |
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