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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Novel insecticidal toxins from the bacterinm Photorhabdus luminescens显示文摘 | Bowen D J Rochelean T A Blackburn M | 1998 | Science1998，6，： | 1 |
| 3 | Relationship between molecule mass and duration of activity of polyethylene glycol conjugated granuloeyte colony - stimulating faetor mutein显示文摘 | Bowen S Tare N Inoue T | 1999 | Exp Hematol1999，27，： | 1 |
| 4 | Loyalty:A strategic commitment显示文摘 | Bowen J T Shoemaker S | 1998 | Cornell Ho- tel and Restaurant Administration Quarterly1998，39，1： | 1 |
| 5 | Artefacts in AFM studies of membranes: Correcting pore images using fast fourier transform filtering显示文摘 | Doneva T A | 2000 | J Membr Sci2000，171，： | 1 |
| 6 | Neutron activation analysis of lanthanide elementsin seawater 显示文摘 | Hogdahl O T Melson S Bowen V T | 1968 | Advances in Chemistry1968，73，： | 1 |
| 7 | Esterase and malate dehydrogenase isozyme polymorphisms in15 Artemia populations显示文摘 | Bowen S T Sterling G | 1978 | Comp Biochem Physiol1978，61，： | 1 |
| 8 | Novel insecticidal toxins from the bacterium Photorhabdus luminescens显示文摘 | Bowen D J Rochelle T A Blackburn M | 1998 | Science1998，6，： | 1 |
| 9 | Agrin acts via a MuSK receptor complex显示文摘 | Glass D J Bowen D C Stitt T N | 1996 | Cell1996，85，4： | 1 |
| 10 | Artemia haemoglobins: genetic variationin parthenogenetic and zygogenetic populations显示文摘 | Bowen S T Durkin J P Stering G | 1978 | Biol Bull1978，155，： | 1 |
| 11 | Arbovirus infectionsin Sarawak, October 1968-February 1970 Tembusu and Sindbis vi- rus isolations from mosquitoes 显示文摘 | PLATT G S WAY H J BOWEN E T | 1975 | Ann Trop Med Parasitol1975，69，1： | 1 |
| 12 | The use of atomic force microscopy to quantify membrane surface electrical properties 显示文摘 | Bowen W R Doneva T A Austin J Stoton G | 2002 | Colloids Surf A: Physicochem Eng Aspects2002，201，： | 1 |
| 13 | Control of cytokine gene transcription in Thl and Th2 cells 显示文摘 | Bowen H Kelly A Lee T | 2008 | Clin Exp Allergy2008，38，9： | 1 |
| 14 | The relationship between customer loyalty and customer satisfaction 显示文摘 | Bowen J T Chen S L | 2001 | International Journal of Contemporary Hospitality Management2001，13，5： | 1 |
| 15 | MicroRNAs, transforming growth factor beta - 1, and tissue fibrosis 显示文摘 | Bowen T Jenkins RH Fraser DJ | 2013 | J Pathol2013，229，2： | 1 |
| 16 | Stenting in acute coronary syndrome: a comparison of radial versus femoral access sites显示文摘 | Mann T Cubeddu G Bowen J | 1998 | J Am Coll Cardiol1998，32，： | 1 |
| 17 | Determinants of the Timing of Quarterly Earnings Announcements显示文摘 | Bowen R M Johnson T Shevlin D Shores | 1992 | Journal of Accounting Auditing and Finance1992，，3： | 1 |
| 18 | Stenting in acut ecoronary syndromes:a comp arison of radial versus femoral access sites显示文摘 | Mann T Cubeddu G Bowen J | 1998 | J Am Coll Cardiol1998，32，1： | 1 |
| 19 | DNA Fingerprints from Hypervariable Mitochondrial DNA Genotypes 显示文摘 | AVISE J C BOWEN B W LAMB T | 1989 | Molecular Biology and Evolution1989，6，： | 1 |
| 20 | Novel insecticidal toxins from the bacterium Photorhabdus luminescens显示文摘 | Bowen D J Rocheleau T A Blackburn M | 1998 | Science1998，6，： | 1 |
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