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| 1 | Mechanical and cellular processes driving cervical myelopathy显示文摘Cervical myelopathy is a well-described clinical syndrome that may evolve from a combination of etiological mechanisms. It is traditionally classified by cervical spinal cord and/or nerve root compression which varies in severity and number of levels involved. The vast array of clinical manifestations of cervical myelopathy cannot fully be explained by the simple concept that a narrowed spinal canal causes compression of the cord, local tissue ischemia, injury and neurological impairment. Despite advances in surgical technology and treatment innovations, there are limited neuro-protective treatments for cervical myelopathy, which reflects an incomplete understanding of the pathophysiological processes involved in this disease. The aim of this review is to provide a comprehensive overview of the key pathophysiological processes at play in the development of cervical myelopathy. | Roisin T Dolan Joseph S Butler John M O'Byrne Ashley R Poynton | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Blue and red laser action in Nd3+,Pr3+ codoped fluorozirconate glass显示文摘 | GOH S C PATTIE R BYRNE C | 1995 | Applied physics letters1995，67，6： | 2 |
| 4 | Ifosfamide,etoposide and epirubicin is an effective combined salvage and peripheral blood stem cell mobihsation regimen for transplant-eligible patients with non-Hodgkin lymphoma and Hodgkin disease 显示文摘 | Bishton M J Lush R J Byrne JL el al | 2007 | Br J Haematol2007，136，5： | 1 |
| 5 | Kinetics of allergen-induced airway eosinophilic cytokine production and airway inflammation显示文摘 | GAUVREAU G M WATSON R M O'BYRNE P M | 1999 | Am J Respir Crit Care Med1999，160，2： | 1 |
| 6 | Seismic Response and Liq- uefaction of Sands显示文摘 | Finn W D Byrne P M Martin G R | 1976 | Journal 05 Geotechnical Engineering Di vision ASCE1976，102，8： | 1 |
| 7 | Post operative endophthalmitis resulting from prosthesiscontamination in a monocular patient显示文摘 | Morris R Camesasca FI Byrne J | | 0，，： | 1 |
| 8 | Inorganic speciation of dissolved elements in seawater: the influence of pH on concentration ratios 显示文摘 | Byrne R H | 2002 | Geochemical Transactions2002，3，2： | 1 |
| 9 | Influence of LCF overloads on combined HCF/LCF crack growth 显示文摘 | Byrne J Hall R F Powell B E | 2003 | International Journal of Fatigue2003，25，911： | 1 |
| 10 | Immobiltisation of TiO2 powder for the treatment of polluted water显示文摘 | Byrne J A Eggins B R Brown M | 1998 | Appl Catal B:Environment1998，17，： | 1 |
| 11 | Early experience in the treatment of intracranial aneurysms by endovascular flow diversion:a multicentre prospective study显示文摘 | Byrne JV Beltechi R Yarnold JA | 2010 | PLoS One2010，5，9： | 1 |
| 12 | Plant stern cells: divergent pathways and common themes in shoots and roots显示文摘 | BYRNE M E KIDNER C A MARTIENSSEN R A | 2003 | Current Opinion in Genetics & Development2003，13，5： | 1 |
| 13 | Rare earth element scavenging in seawater 显示文摘 | Byrne R H Kim K H | 1990 | Geochiimica et Cosmochimica Acta1990，54，： | 1 |
| 14 | Pho- tocatalytic degradation of 17-β-oestradiol on immobilised TiO2 显示文摘 | Coleman H M Eggins B R Anthony Byrne J | 2000 | Appl Catal B : Environ2000，24，1： | 1 |
| 15 | Pancreatitis显示文摘 | MITCHELL R M S BYRNE M F BAILLIE J | 2003 | lancet2003，361，9367： | 1 |
| 16 | Evaluation of a Treponema pallidum Western immunoblot assay as a confirmatory test for syphilis显示文摘 | Byrne R E Laska S Bell M | 1992 | J Clin Microbiol1992，30，： | 1 |
| 17 | The antioxi dative activity of plant extracts in cooked pork patties as evalua ted by descriptive sensory profiling and chemical analysis显示文摘 | Lise R Nissen Derek V Byrne Grete Bertelsen | 2004 | Meat Science2004，68，3： | 1 |
| 18 | Cysteinyl leukotrienes promote human airway smooth muscle migration 显示文摘 | Parameswaran K Cox G Radford K Janssen LJ Sehmi R O'Byrne PM | 2002 | Am J Respir Crit Care Med2002，166，5： | 1 |
| 19 | Student Use and Perceptions of Different Learning Aids in a Problem-Based Learning (PBL) Dentistry Course显示文摘 | Gerzina TM Worthington R Byrne S McMahon C etc | 2003 | Journal of Dental Education2003，67，6： | 1 |
| 20 | E-cadherin immunostaining of bladder transitional cell carcinoma,carcinoma in situ and lymph node metastases with long-term followup显示文摘 | BYRNE R R SHARIAT S F BROWN R | 2001 | J Urol2001，165，5： | 1 |
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