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| 1 | Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis显示文摘AIM To characterize the gut bacterial microbiota of patients with primary sclerosing cholangitis(PSC) and ulcerative colitis(UC).METHODS Stool samples were collected and relevant clinical data obtained from 106 study participants, 43 PSC patients with(n = 32) or without(n = 11) concomitant inflammatory bowel disease, 32 UC patients, and 31 healthy controls. The V3 and V4 regions of the 16 S ribosomal RNA gene were sequenced on Illumina Mi Seq platform to cover low taxonomic levels. Data were further processed in QIIME employing Ma As Lin and LEf Se tools for analysis of the output data.RESULTS Microbial profiles in both PSC and UC were characterized by low bacterial diversity and significant change in global microbial composition. Rothia, Enterococcus, Streptococcus, Veillonella, and three other genera were markedly overrepresented in PSC regardless of concomitant inflammatory bowel disease(IBD). Rothia, Veillonella and Streptococcus were tracked to the species level to identify Rothia mucilaginosa, Streptococcus infantus, S. alactolyticus, and S. equi along with Veillonella parvula and V. dispar. PSC was further characterized by decreased abundance of Adlercreutzia equolifaciens and Prevotella copri. Decrease in genus Phascolarctobacterium was linked to presence of colonic inflammation regardless of IBD phenotype. Akkermansia muciniphila, Butyricicoccus pullicaecorum and Clostridium colinum were decreased in UC along with genus Roseburia. Low levels of serum albumin were significantly correlated with enrichment of order Actinomycetales.CONCLUSION PSC is associated with specific gut microbes independently of concomitant IBD and several bacterial taxa clearly distinguish IBD phenotypes(PSC-IBD and UC). | Lukas Bajer Miloslav Kverka Martin Kostovcik Peter Macinga Jiri Dvorak Zuzana Stehlikova Jan Brezina Pavel Wohl Julius Spicak Pavel Drastich | 2017 | World Journal of Gastroenterology2017，23，25： | 22 |
| 2 | Simultaneous occurrence of autoimmune pancreatitis and pancreatic cancer in patients resected for focal pancreatic mass显示文摘AIM To assess the occurrence of autoimmune pancreatitis(AIP) in pancreatic resections performed for focal pancreatic enlargement.METHODS We performed a retrospective analysis of medical records of all patients who underwent pancreatic resection for a focal pancreatic enlargement at our tertiary center from January 2000 to July 2013. The indication for surgery was suspicion of a tumor based on clinical presentation, imaging findings and laboratory evaluations. The diagnosis of AIP was based on histology findings. An experienced pathologist specialized in pancreatic disease reviewed all the cases and confirmed the diagnosis in pancreatic resection specimens suggestive of AIP. The histological diagnosis of AIP was set according to the international consensus diagnostic criteria.RESULTS Two hundred ninety-five pancreatic resections were performed in 201 men and 94 women. AIP was diagnosed in 15 patients(5.1%, 12 men and 3 women) based on histology of the resected specimen. Six of them had AIP type 1, nine were diagnosed with AIP type 2. Pancreatic adenocarcinoma(PC) was also present in six patients with AIP(40%), all six were men. Patients with AIP + PC were significantly older(60.5 vs 49 years of age, P = 0.045), more likely to have been recently diagnosed with diabetes(67% vs 11%, P = 0.09), and had experienced greater weight loss(15.5 kg vs 8.5 kg, P = 0.03) than AIP patients without PC. AIP was not diagnosed in any patients prior to surgery; however, the diagnostic algorithm was not fully completed in every case. CONCLUSION The possible co-occurrence of PC and AIP suggests that preoperative diagnosis of AIP does not rule out simultaneous presence of PC. | Peter Macinga Adela Pulkertova Lukas Bajer Jana Maluskova Martin Oliverius Martin Smejkal Maria Heczkova Julius Spicak Tomas Hucl | 2017 | World Journal of Gastroenterology2017，23，12： | 5 |
| 3 | Risk of recurrence of primary sclerosing cholangitis after liver transplantation is associated with de novo inflammatory bowel disease显示文摘AIM To evaluate risk factors for primary sclerosing cholangitis(PSC) recurrence(rPSC) after orthotopic liver transplantation(OLT) in patients with well-preserved colons. METHODS We retrospectively evaluated the medical records of all patients transplanted for PSC in our center between July 1994 and May 2015 and selected 47 with followup of at least 60 mo for further analysis based on strict inclusion and exclusion criteria. rPSC was confirmed by magnetic resonance or endoscopic retrograde cholangiopancreatography and liver biopsy. All patients were evaluated by protocolary pre-OLT colonoscopy with randomized mucosal biopsies. Colonoscopy was repeated annually after OLT. Both organ donors and recipients were human leukocyte antigen(HLA) typed by serological and/or DNA methods. All input data were thoroughly analyzed employing relevant statistical methods.RESULTS Altogether, 31 men and 16 women with a median(range) age of 36(15-68) years at the time of OLT and a median follow-up of 122(60-249) mo were included. rPSC was confirmed in 21/47(44.7%) of patients, a median 63(12-180) mo after transplantation. De novo colitis [rPSC in 11/12, P ≤ 0.05, hazard ratio(HR): 4.02, 95% confidence interval(CI): 1.58-10.98] and history of acute cellular rejection(rPSC in 14/25, P ≤ 0.05; HR: 2.66, 95%CI: 1.03-7.86) showed strong positive associations with rPSC. According to the univariate analysis, overlapping features of autoimmune hepatitis(r PSC in 5/5, P ≤ 0.05) and HLA-DRB1*07 in the donor(r PSC in 10/15, P ≤ 0.05) represent other potential risk factors for rPSC, while the HLA-DRB1*04(rPSC in 0/6, P ≤ 0.05), HLA-DQB1*03(rPSC in 1/11, P ≤ 0.05), and HLA-DQB1*07(rPSC in 0/7, P ≤ 0.05) recipient alleles may have protective roles.CONCLUSION De novo colitis and acute cellular rejection are clinical conditions significantly predisposed towards recurrence of PSC after liver transplantation. | Lukas Bajer Antonij Slavcev Peter Macinga Eva Sticova Jan Brezina Matej Roder Radim Janousek Pavel Trunecka Julius Spicak Pavel Drastich | 2018 | World Journal of Gastroenterology2018，24，43： | 4 |
| 4 | Dynamic contact/impact problems,energy conservation,and planetary gear trains显示文摘 | Bajer A Demkowicz L | 2002 | Computer Methods in Applied Mechanics and Engineering2002，191，3738： | 1 |
| 5 | Relationships of calcium content to respiration and postharvest condition of appies显示文摘 | BRAMLOGE W J DRAKE M BAJER J H | 1974 | Journal of American Society of Horticultural Science1974，99，： | 1 |
| 6 | Dual mechanisms of sHA 14-1 in inducing cell death through endoplasmic reticulum and mitochondria 显示文摘 | HERMANSON D ADDO S N BAJER A A | 2009 | Mol Pharrnaco12009，76，3： | 1 |
| 7 | Com- parison of three different solid-phase microextraction fibres for anal- ysis of essential oils in yacon leaves显示文摘 | ADAM M JUKLOVA M BAJER T EISNER K VENTURA | 2005 | Journal of Chromatography A2005，1084，： | 1 |
| 8 | Oryzalin,a dinitroaniline herbicide,binds to plant tubulin and inhibits microtubule polymerization in vitro显示文摘 | Morejohn L Bureau T Molè-Bajer J Bajer A Fosket D | 1987 | Planta1987，172，2： | 1 |
| 9 | Dynamic Contact/impact Problems, Energy Conservation, and Planetary Gear Trains 显示文摘 | BAJER A Demkowicz L | 2002 | Computer Methods in Applied Mechanics and Engineering2002，191，： | 1 |
| 10 | Dynamic contact/impact problems, energy conservation, and planectary Gear Ttraina 显示文摘 | Bajer A Demkowicz L | 2002 | Com- puter Methods in Applied Mechanics and Engineering2002，191，37： | 1 |
| 11 | Relationships of calcium content to respiration and postharvest condition of apples显示文摘 | Bramloge W J Drake M Bajer J H | 1974 | Journal of American Society of Horticultural Science1974，99，： | 1 |
| 12 | Dynamic contact/ impact problems,energy conservation,and planetary显示文摘 | Bajer A Demkowicz L | 2002 | Gear Ttrains2002，191，3738： | 1 |
| 13 | A non-sequence- specific requirement for SMN protein activity: the role of aminoglycosides in inducing elevated SMN protein levels显示文摘 | Wolstencroft EC Mattis V Bajer AA | 2005 | Hum Mol Genet2005，14，9： | 1 |
| 14 | Dynamic contact/impact problems,energy conservation, and planetary gear trains 显示文摘 | Bajer A Demkowicz L | 2002 | Com-puter Methods in Applied Mechanics and Engineering2002，191，3738： | 1 |
| 15 | Stock Option Compensation and Earnings Management Incentives 显示文摘 | Bajer T Collins D Reitenga A | 2003 | Journal of Accounting2003，18，4： | 1 |
| 16 | Peripheral blood-derived bovine dendritic cells promote IgGl-restricted B cell responses in vitro 显示文摘 | Bajer AA Tapia DG jordan KR | 2003 | J Leukoe Bio12003，73，1： | 1 |
| 17 | Factors affecting the component community structure of haemoparasites in common vole Clethrionomys arvalis from the Mazury Lake District region of Poland 显示文摘 | Bajer A Pawelczyk A Behnke JM | 2001 | Parasitology2001，122，： | 1 |
| 18 | From ??feathers to syngas-technologies and devices显示文摘 | Marek Dudynski Kamil Kwiatkowski Konrad Bajer | 2012 | Waste Management2012，32，4： | 1 |
| 19 | Dynamic Contact/impact Problems, Energy Conservation and Planetary Gear Trains 显示文摘 | A Bajer L Demkowicz | 2002 | Compu- ter Methods in Applied Mechanics and Engineering2002，191，： | 1 |
| 20 | Spectroscopic studies of polyaniline protonation with poly(alkylene phosphates) 显示文摘 | Kulszewicz Bajer I Sobczak J Hasik M | 1996 | Polymer1996，37，1： | 1 |
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