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| 1 | 5-ASA colonic mucosal concentrations resulting from different pharmaceutical formulations in ulcerative colitis显示文摘AIM:To compare the mucosal concentrations of 5-aminosalicylic acid(5-ASA)resulting from different pharmaceutical formulations and analyse the influence of inflammation on the mucosal concentrations.METHODS:The study included 130 inflammatory bowel disease(IBD)patients receiving 5-ASA as pH-dependent-release formulations(73 patients),time-dependent-release formulations(11 patients),or pro-drugs(18patients).In addition,28 patients were receiving topical treatment(2-4 g/d)with pH-dependent-release formulations.Endoscopic biopsies were obtained from the sigmoid region during the colonoscopy.The 5-ASA concentrations(ng/mg)were measured in tissue homogenatesusing high-pressure liquid chromatography with electrochemical detection.The t test and Mann-Whitney test,when appropriate,were used for statistical analysis.RESULTS:Patients receiving pH-dependent-release formulations showed significantly higher mucosal concentrations of 5-ASA(51.75±5.72 ng/mg)compared with patients receiving pro-drugs(33.35±5.78 ng/mg,P=0.01)or time-dependent-release formulations(38.24±5.53 ng/mg,P=0.04).Patients with endoscopic remission had significantly higher mucosal concentrations of5-ASA than patients with active disease(60.14±7.95ng/mg vs 35.66±5.68 ng/mg,P=0.02).Similar results were obtained when we compared patients with the histological appearance of remission and patients with active histological inflammation(67.53±9.22 ng/mg vs 35.53±5.63 ng/mg,P<0.001).Significantly higher mucosal concentrations of 5-ASA were detected in patients treated with both oral and topical treatments in combination compared with patients who received oral treatment with pH-dependent-release formulations alone(72.33±11.23 ng/mg vs 51.75±5.72 ng/mg,P=0.03).CONCLUSION:IBD patients showed significant variability in mucosal 5-ASA concentrations depending on the type of formulation,and the highest mean concentration was achieved using pH-dependent-release formulations. | Renata D’Incà Martina Paccagnella Romilda Cardin Surajit Pathak Vincenzo Baldo Maria Cecilia Giron Giacomo Carlo Sturniolo | 2013 | World Journal of Gastroenterology2013，19，34： | 4 |
| 2 | High efficient phosphorescent emission from organic electroluminescent diodes 显示文摘 | Baldo M A O'brien D F | 1998 | Nature1998，395，： | 1 |
| 3 | Highly efficient phosphorescent emission from organic electroluminescent devices 显示文摘 | Baldo M A O′Brien D F You Y | 1998 | Nature1998，395，10： | 1 |
| 4 | Highly efficient phosphorescent emission from organic electroluminescence devices显示文摘 | Baldo M A O'Brien D F You Y Shoustikov A Sibley S Thompson M E Forret S R | | 0，，： | 1 |
| 5 | Highly efficient phosphorescent emission from organic electroluminescent devices 显示文摘 | BALDO M A O'BRIEN D F YOU Y | 1998 | Nature1998，395，： | 1 |
| 6 | A framework for computer-assisted creation of dy- namic virtual organisations 显示文摘 | Camarinha-Matos LM Oliveira AI Sesana M Galeano N Demsar D Baldo F | 2009 | International Journal of Production Re- search2009，47，17： | 1 |
| 7 | 查看详情显示文摘 | Baldo M A OBrien D F You Y | | 0，，： | 1 |
| 8 | Right congenital diaphragmatic hernia:an 18-year experience显示文摘 | Midrio P Gobbi D Baldo V | 2007 | J Pediatr Surg2007，42，3： | 1 |
| 9 | Highly efficient phosphorescent emission from organic electroluminescent devices显示文摘 | Baldo M A O'Brien D F You Y | 1998 | Nature1998，395，6698： | 1 |
| 10 | Highly efficient phosphorescent emission from organic electroluminescent devices 显示文摘 | Baldo M A O' Brien D F You Y | 1998 | Nature1998，395，： | 1 |
| 11 | Highly Efficient Phosphorescent Emission from Organic Electroluminescent Devices显示文摘 | Baldo M A O'Brien D F Forrest S R | 1998 | Nature1998，395，10： | 1 |
| 12 | Highly efficient phosphorescent emission from organic electrolumineseent devices 显示文摘 | Baldo M A O'Brien D F Shoustikov Y A | 1998 | Nature1998，395，6698： | 1 |
| 13 | Highly efficient phosphorescent emission fromorganic electroluminescent devices 显示文摘 | Baldo M A O'Brien D F You Y | 1998 | Nature1998，395，： | 1 |
| 14 | Excitonic singlet-triplet ratio in a semiconductingorganic thin film显示文摘 | BALDO M A O′BRIEN D F THOMPSON M E etal | 1999 | Physical Review B1999，60，14： | 1 |
| 15 | Highly efficient phosphorescent emission from organic electroluminescent devices显示文摘 | Baldo M A O'Brien D F You Y | 1998 | Nature1998，395，： | 1 |
| 16 | Highly efficient phosphorescent emission fromorganic electrolum1inescent devices显示文摘 | Baldo M A O'Brien D F You Y | 1998 | Nature1998，395，： | 1 |
| 17 | Highly efficient phosphorescent emission from organic electroluminescent devices显示文摘 | BALDO M A O' BRIEN D F YOU Y | 1998 | Nature1998，395，： | 1 |
| 18 | High efficient phosphorescent emission from organic electroluminescent devices显示文摘 | Baldo MA O' Brien D F YouY | 1998 | Nature1998，35，6698： | 1 |
| 19 | Dynamic properties of a model polymer/metal nanocomposite:gold particles in poly(tertbutyl acrylate)显示文摘 | Cole D H Shull K R Baldo P | 1999 | Macromolecules1999，32，3： | 1 |
| 20 | Highly efficient phosphorescent emission from organic electroluminescent devices显示文摘 | Baldo M A O'Brian D F You Y | | 0，，01： | 1 |
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