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| 1 | 英国胃肠病学会关于胃癌风险患者的诊断和管理指南显示文摘胃癌预后较差,部分原因在于诊断较晚。胃癌的危险因素包括幽门螺杆菌(H.pylori,HP)感染和胃癌家族史,尤其是遗传性弥漫性胃癌和恶性贫血。胃癌发展的阶段包括慢性胃炎、胃黏膜萎缩(GA)、胃黏膜肠化生(GIM)和异型增生。胃癌早期发现和提高生存率的关键是在内镜检查前以非侵入性方式识别高危人群。然而,尽管生物标志物可能有助于检测慢性萎缩性胃炎,但尚无足够的证据支持其用于人群筛查。高质量内镜检查是胃癌早期发现的重要组成部分,图像增强内镜结合组织病理学活检是GA和GIM最佳的诊断方法,并能准确进行风险分层。按照悉尼标准从胃窦、角切迹、小弯和大弯进行活检,既能明确诊断,也能对胃癌进行风险分层。理想状态应当是在高质量内镜检查中对GA或GIM区域活检。英国属于低危地区,可根据需要接受常规诊断性胃镜检查,但没有足够证据支持筛查,对于广泛GA或GIM的患者,每3年检查内镜。对于胃异型增生和早期癌,只要满足标准,内镜下黏膜切除术或内镜黏膜下剥离术的治疗有效,成功率高,复发率低。 | Matthew Banks David Graham Marnix Jansen TakujiGotoda Sergio Coda Massimiliano di Pietro NoriyaUedo Pradeep Bhandari D Mark Pritchard Ernst J Kuipers Manuel Rodriguez-Justo Marco R Novelli KrishRagunath Neil Shepherd Mario Dinis-Ribeiro 乌雅罕(译) 张冬雪(译) 牛占岳(校) 刘鑫(校) 丁士刚(译/校) | 2020 | 中华胃肠内镜电子杂志2020，7，2： | 10 |
| 2 | Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease显示文摘AIM To determine levels of cytokines incolonic mucosa of asymptomatic first degreerelatives of Crohn’s disease patients.METHODS Cytokines(Interleukin(IL)1-Beta,IL-2,IL-5 and IL-8)were measured using ELISAin biopsy samples of normal looking colonicmucosa of first degree relatives of Crohn’sdisease patients(n = 9)and from normalcontrols(n = 10)with no family history ofCrohn’s disease.RESULTS Asymptomatic first degree relativesof patients with Crohn’s disease had significantlyhigher levels of basal intestinal mucosalcytokines(IL-2,IL-5 and IL-8)than normalcontrols.Whether these increased cytokinelevels serve as phenotypic markers for a geneticpredisposition to developing Crohns diseaselater on,or whether they indicate early(pre-clinical)damage has yet to be further defined.CONCLUSION Asymptomatic first degreerelatives of Crohn’s disease patients have higherlevels of cytokines in their normal-lookingintestinal mucosa compared to normal controls,This supports the hypothesis that increasedcytokines may be a cause or an early event inthe inflammatory cascade of Crohns disease andare not merely a result of the inflammatoryprocess. | Indaram AVK Nandi S Weissman S Lam S Bailey B Blumstein M Greenberg R Bank S | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 3 | Nonlinear terahertz devices utilizing semiconducting plasmonic metamaterials显示文摘The development of responsive metamaterials has enabled the realization of compact tunable photonic devices capable of manipulating the amplitude,polarization,wave vector and frequency of light.Integration of semiconductors into the active regions of metallic resonators is a proven approach for creating nonlinear metamaterials through optoelectronic control of the semiconductor carrier density.Metal-free subwavelength resonant semiconductor structures offer an alternative approach to create dynamic metamaterials.We present InAs plasmonic disk arrays as a viable resonant metamaterial at terahertz frequencies.Importantly,InAs plasmonic disks exhibit a strong nonlinear response arising from electric field-induced intervalley scattering,resulting in a reduced carrier mobility thereby damping the plasmonic response.We demonstrate nonlinear perfect absorbers configured as either optical limiters or saturable absorbers,including flexible nonlinear absorbers achieved by transferring the disks to polyimide films.Nonlinear plasmonic metamaterials show potential for use in ultrafast terahertz(THz)optics and for passive protection of sensitive electromagnetic devices. | Huseyin R Seren Jingdi Zhang George R Keiser Scott J Maddox Xiaoguang Zhao Kebin Fan Seth R Bank Xin Zhang Richard D Averitt | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 4 | Hepatitis E: an emerging infection in developed countries显示文摘 | Harry R Dalton Richard Bendall Samreen Ijaz Malcolm Banks | 2008 | The Lancet Infectious Diseases2008，，11： | 2 |
| 5 | Loss of T cell precursors after spaceflight and exposure to vector-averaged gravity显示文摘 | Woods CC Banks KE Gruener R | 2003 | FASEBJ2003，17，11： | 1 |
| 6 | Firstsemester grades,thought modes,and undergraduate persistence显示文摘 | BIDDL B J &SHAVINGS R L | 1994 | Contemporary Educatonal Psychology1994，19，： | 1 |
| 7 | Simulation modeling:some programing required显示文摘 | Gibson R | 1997 | IIE Solutions1997，，2： | 1 |
| 8 | A phase I/II clinical trial of beta-globin gene therapy for beta-thalassemia显示文摘 | Bank A Dorazio R Leboulch P | 2005 | Ann N Y Acad Sci2005，1054，1： | 1 |
| 9 | Wolbachia infections of the whitefly Bemisia tabaci显示文摘 | Nirglanaki A Banks G K Frohlich D R | 2003 | Curr Microbiol2003，47，2： | 1 |
| 10 | Efficacy ofpositive airway pressure and oral appliance in mild tomoderate obstructive sleep apnea显示文摘 | Barnes M McEvoy R D Banks S | 2004 | Am J Respir CritCare Med2004，170，6： | 1 |
| 11 | A framework for variation discovery and genotyping using next-generation DNA sequencing data显示文摘 | DePristo MA Banks E Poplin R | 2011 | Nat Genet2011，43，5： | 1 |
| 12 | Effect of Dietary Calcium and Vitamin D3 on Calcium and Phosphorus Retention in White Pekin Ducklings 显示文摘 | Rush J K Angel C R Banks K M | 2005 | Poult Sci2005，84，： | 1 |
| 13 | Nucleic acid sequence-based amplification methods to detect avian influenza virus 显示文摘 | Lau L T Banks J Aherne R | 2004 | Biochem Biophys Res Commun2004，313，2： | 1 |
| 14 | Preparation of 2,3,3,3-tetrafluoropropene from trifluoroacetylacetone and sulphur tetrafluoride显示文摘 | Banks R E Barlow M G Nickkho-Amiry M | 1997 | J Fluorine Chem1997，82，2： | 1 |
| 15 | Electroanalytical determination of cadmium(II)and lead(II)using an in-situbismuth film modified edge plane pyrolytic graphite electrode显示文摘 | KACHOOSANGI R T BANKS C E JI X | 2007 | Analytical Sciences2007，23，3： | 1 |
| 16 | Effects of extraction conditions and alkali type on yield and composition of wheat straw hemicellulose显示文摘 | LAWTHER J M SUN R C BANKS W B | 1996 | J Appl Polym Sci1996，60，11： | 1 |
| 17 | Motor and somatosensory deficits following uni-and bilateral lesions of the cortex induced by aspiration or thermocoagulation in the adult rat显示文摘 | Napieralski J A Banks R J Chesselet M F | 1998 | Exp Neurol1998，154，1： | 1 |
| 18 | Flow visualization of conical vortices on flat roofs with simultaneous surface pressure measurement 显示文摘 | Banks D Meroney R N Sarkar P P | 2000 | Journal of Wind Engineering and Industrial Aerodynamics2000，84，： | 1 |
| 19 | DNA barcoding the floras of biodiversity hotspots显示文摘 | Lahaye R van der Bank M Bngarin D | 2008 | Proceedings of the National Academy of Sciences USA2008，105，： | 1 |
| 20 | A class of iterative methods for solving saddle point problems显示文摘 | Bank R E Welfert B D Yserentant H | 1990 | Numer Math1990，56，： | 1 |
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