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| 1 | Impact of proteolytic enzymes in colorectal cancer development and progression显示文摘Tumor invasion and metastasis is a highly complicated, multi-step phenomenon. In the complex event of tumor progression, tumor cells interact with basement membrane and extracellular matrix components. Proteolytic enzymes(proteinases) are involved in the degradation of extracellular matrix, but also in cancer invasion and metastasis. The four categories of proteinases(cysteine-, serine-, aspartic-, and metalloproteinases) are named and classified according to the essential catalytic component in their active site. We and others have shown that proteolytic enzymes play a major role not only in colorectal cancer(CRC) invasion and metastasis, but also in malignant transformation of precancerous lesions into cancer. Tissue and serumplasma antigen concentrations of proteinases might be of great value in identifying patients with poor prognosis in CRC. Our results, in concordance with othersindicate the potential tumor marker impact of proteinases for the early diagnosis of CRC. In addition, proteinases may also serve as potential target molecules for therapeutic agents. | László Herszényi Loránd Barabás István Hritz Gábor István Zsolt Tulassay | 2014 | World Journal of Gastroenterology2014，20，37： | 3 |
| 2 | Weighted evolving networks显示文摘 | Yook S H Jeong H Barabási A-L | 2001 | Phys Rev Lett2001，86，： | 1 |
| 3 | Weighted evolving networks显示文摘 | YOOK S H JEONG H BARAB(A)SI A L | 2001 | Physical Review Letters2001，86，18： | 1 |
| 4 | Lethality and centrality in protein networks显示文摘 | Jeong H Mason S Barab~isi A L | 2001 | Nature2001，411，： | 1 |
| 5 | Lethality and centrality in protein networks显示文摘 | Jeong H Mason S P Barabási A L Oltvai Z N | 2001 | Nature2001，411，： | 1 |
| 6 | Weighted Evolving Networks显示文摘 | YOOK S H JEONG H BARABáSI A L | 2001 | Physical Review Letters2001，86，25： | 1 |
| 7 | Lethality and Centrality of Protein Networks显示文摘 | Je?ng H Mason S Barabási A L | 2001 | Nature2001，411，6833： | 1 |
| 8 | Inhibitory effect of a long-acting somatostatin analogue on EGF-stimulated cell proliferation in Capan-2cells显示文摘 | Burghardt B Barabás K Marcsek Z | 2000 | J Physiol Paris2000，94，1： | 1 |
| 9 | Modeling the Intemet' s Large-Scale Topology显示文摘 | Yook S H Jeong H Barabási A-L | 2002 | PNAS2002，99，13： | 1 |
| 10 | weighted evolving networks显示文摘 | Jeong H Barabási A L | 2001 | Phys Rev Lett2001，86，25： | 1 |
| 11 | Lethality and centrality in protein networks显示文摘 | Jeong H Mason S Barabási A L Oltvai Z N | 2001 | Nature2001，411，： | 1 |
| 12 | Weighted E-volving Networks显示文摘 | S H Yook H Jeong A-L Barabási Y Tu | | 0，，86： | 1 |
| 13 | Lethality and centrality in protein networks显示文摘 | Mason S Barabási A L Oltvai Z N | 2001 | Nature2001，411，： | 1 |
| 14 | Common cuckoo Cuculus canorus parasitism,antiparasite defence and gene flow in closely located populations of great reed warblers Acrocephalus arundinaceus显示文摘 | Moskát C Hansson B Barabás L Bártol I Karcza Z | | 0，，： | 1 |
| 15 | Lethality and centrality in protein networks显示文摘 | Jeong H Mason S Barab'asi A -L | 2001 | Nature2001，411，： | 1 |
| 16 | Weighted evolving networks显示文摘 | Yook S H Jeong H Barabési A L | 2001 | Phys Rev Lett2001，86，： | 1 |
| 17 | Functional and topological characterization of protein interaction networks显示文摘 | Yook S - H Oltvai Z N Barabáási A - L | 2004 | Proteomics2004，4，： | 1 |
| 18 | Lethality and centrality in protein networks显示文摘 | Jeong H Mason S P Barabási A - L Oltvai Z N | 2001 | Nature2001，411，： | 1 |
| 19 | Weighted evolving networks 显示文摘 | YOOK S H JEONG H BARAB/tSI A L | 2001 | Physical Review Letters2001，86，25： | 1 |
| 20 | Glutamate uptake triggers trans-porter-mediated GABA release from astrocytes显示文摘 | Héja L Kardos J Barabás P | 2009 | PLoS One2009，4，9： | 1 |
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