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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 3 | Phosphorus-31 nuclear magnetic resonance spectroscopic determination of phytate in foods显示文摘 | Eugene P M Brian Q P Barbara F H | 1986 | Journal of Agricultural and Food Chemistry1986，34，1： | 1 |
| 4 | The ecology of medical care revisited显示文摘 | Larry A Green George E Fryer Jr Barbara P Yawn David lanier Susan M Dovey | 2001 | The New England Journal of Medicine2001，334，26： | 1 |
| 5 | CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients显示文摘 | Savoldo Barbara Ramos Carlos Almeida Liu Enli Mims Martha P Keating Michael J Carrum George Kamble Rammurti T Bollard Catherine M Gee Adrian P Mei Zhuyong Liu Hao Grilley Bambi Rooney Cliona M Heslop Helen E Brenner Malcolm K Dotti Gianpie | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 6 | Uranium reduction by desulfovibrio desulfuricans strain G20 and a cytochrome c3 mutant 显示文摘 | Rayford B P Darren M G Barbara J R | 2002 | Applied and Environmental Microbiology2002，68，6： | 1 |
| 7 | Composition of milk and blood metabolites in high productivity dairy cows on pasture显示文摘 | Cezary P Barbara P Dariusz M | 2005 | VETERINARIJA IR ZOOTECHNIKA2005，32，54： | 1 |
| 8 | Antithrombotic activity of a fucosylated chondroitin sulphate from echinoderm: sulphated fucose branches on the polysaccharide account for its antithrombotic action 显示文摘 | P A S Mourao M A M Guimaraes Barbara Mulloy | 1998 | British journal of haematology1998，101，4： | 1 |
| 9 | Isotlavones: estro- genicactivity, biological effect and bioavailability显示文摘 | Daniela CV Cateno P Barbara M | 2013 | Eur J Drug Metab Pharmacokinet2013，38，： | 1 |
| 10 | The psychosocial impact of macular degeneration显示文摘 | Williams Rebecca A Brody Barbara M P H Thomas Ronald G | 1998 | Archives of Ophthalmology1998，116，4： | 1 |
| 11 | Simulation of flameless combustion of natural gas in a laboratory scale furnace显示文摘 | SEHASTIEN M BARBARA P PAUL L | 2006 | Turkish J Eng Env Sci2006，，30： | 1 |
| 12 | Dual-regulated expression of C/ EBP-a and BMP-2 enables differential differentiation of C2C12 cells into adipocytes and osteoblasts 显示文摘 | Cornelia F Barbara M Beat P | 2004 | Nucleic Acids Res2004，32，1： | 1 |
| 13 | Intramolecular proton transfer and excited-state relaxation in 2 (2- hydroxyphenyl) benzothiazole显示文摘 | Barbara P F Brus L E Rentzepis P M | 1980 | Journal of the American Chemical Society1980，102，： | 1 |
| 14 | Pasteurella multocida gene expression in response to iron limitation显示文摘 | MICHAEL P BARBARA J M | 2001 | Infect Immun2001，69，6： | 1 |
| 15 | The role of terlipressin in pediatric septic shock: a review of the literature and personal experience 显示文摘 | Papoff P Mancuso M Barbara C S | 2007 | Int J Immunopathol Pharmacol2007，20，2： | 1 |
| 16 | Pluripotency regulators in human mesenchymal stem cells:expression of NANOG but not of OCT-4 and SOX-2 显示文摘 | Enrico P Barbara G Ivana M | 2011 | Stem? Cells Dev2011，20，5： | 1 |
| 17 | The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains显示文摘 | Poulat F Barbara P S Desclozeaux M | 1997 | Boil Chem1997，272，： | 1 |
| 18 | Intramolecular proton transfer and excited - state relaxa- tion in 2-(2-hydroxyphenyl) benzothiazole 显示文摘 | Barbara P F Brus L E Rentzepis P M | 1980 | J Am Chem Soc1980，102，17： | 1 |
| 19 | Dual2regulated expression of C/EBPa and BMP-2 enables differential differentiation of C2C12 cells into adipocytes and osteoblasts显示文摘 | Cornelia F Barbara M Beat P | 2004 | Nucleic Acids Res2004，32，1： | 1 |
| 20 | Characterization of the initial burst release of a model peptide from PLGA microspheres显示文摘 | Juan W Barbara M Steven P | 2002 | J Controlled Release2002，82，23： | 1 |
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