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| 1 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 2 | Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage Ⅱ and Ⅲ rectal adenocarcinoma:The Freiburg experience(1989-2002)显示文摘AIM:To evaluate the long-term outcome of standard5-FU based adjuvant or neoadjuvant radiochemotherapyand to identify the predictive factors,especially anemiabefore and after radiotherapy as well as hemoglobinincrease or decrease during radiotherapy.METHODS:Two hundred and eighty-six patientswith Union International Contre Cancer(UICC)stageⅡ and Ⅲ rectal adenocarcinomas,who underwentresection by conventional surgical techniques(lowanterior or abdominoperineal resection),receivedeither postoperative(n=233)or preoperative(n=53)radiochemotherapy from January 1989 until July 2002.Overall survival(OAS),cancer-specific survival(CSS),disease-free survival(DFS),local-relapse-free(LRS)and distant-relapse-free survival(DRS)were evaluatedusing Kaplan-Meier,Log-rank test and Cox's proportionalhazards as statistical methods.Multivariate analysis wasused to identify prognostic factors.Median follow-uptime was 8 years.RESULTS:Anemia before radiochemotherapy was anindependent prognostic factor for improved DFS(riskratio 0.76,P=0.04)as well as stage,grading,R status(free radial margins),type of surgery,carcinoembryonicantigen(CEA)levels,and gender.The univariate analysisrevealed that anemia was associated with impaired LRS (better local control)but with improved DFS.In contrast,hemoglobin decrease during radiotherapy was anindependent risk factor for DFS(risk ratio 1.97,P=0.04).During radiotherapy,only 30.8% of RO-resected patientssuffered from hemoglobin decrease compared to 55.6%if R1/2 resection was performed(P=0.04).The 5-yearOAS,CSS,DFS,LRS and DRS were 47.0%,60.0%,41.4%,67.2%,and 84.3%,respectively.Significantdifferences between preoperative and postoperativeradiochemotherapy were not found.CONCLUSION:Anemia before radiochemotherapyand hemoglobin decrease during radiotherapy have nopredictive value for the outcome of rectal cancer.Stage,grading,R status(free radial margins),type of surgery,CEA levels,and gender have predictive value for theoutcome of rectal cancer. | Christian Weissenberger Geissler Michael Otto Florian Barke Annette Henne Karl von Plehn Georg Rein Alex Müller Christine Bartelt Susanne Henke Michael | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 3 | Micro-Structured Fiber Interferometer as Sensitive Temperature Sensor显示文摘 | F. C. FAVERO M. BECKER, R. SPITTEL M. ROTHHARDT J. KOBELKE H. BARTELT | 2013 | Photonic Sensors2013，3，3： | 2 |
| 4 | Splicing Gedoped photonic crystal fibers using commercial fusion splicer with default discharge parameters显示文摘 | WANG Y P BARTELT H BRUECKNER S | 2008 | Optics Express2008，16，10： | 1 |
| 5 | Numerical investigation of the influence of rock shape on rockfall trajectory显示文摘 | Glover J Schweizer A Christen M Gerber W Leine R Bartelt P | 2012 | Geophysical Research Abstracts2012，14，11： | 1 |
| 6 | Patients with brain metastases: hope for recursive partitioning analysis (RPA) class 3显示文摘 | Lutterbach J Bartelt S Stancu E | 2002 | Radiother Oncol2002，63，3： | 1 |
| 7 | Brown adipose tissue activitycontrols triglyceride cIearance显示文摘 | Bartelt A Bruns OT Reimer R | 2011 | Nat Med2011，17，2： | 1 |
| 8 | T cell receptor activation leads to two distinct phases of pyk2 activation and actin cytoskeletal rearrangement in human T cells显示文摘 | Collins M Bartelt RR Houtman JC | 2010 | Mol Immunol2010，47，9： | 1 |
| 9 | Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom显示文摘 | Ferreira S H Bartelt D C Greene L J | 1970 | Biochemistry1970，9，13： | 1 |
| 10 | Is older age associated with a worse prognosis due to different patterns of care? A long-term study of 1346 patients with glioblastomas or brain metastases 显示文摘 | Lutterbach J Bartelt S Momm F | 2005 | Cancer2005，103，6： | 1 |
| 11 | Ceramic pistons and bushings in hydrostatic axial piston machines-test procedures and results 显示文摘 | BARTELT H | 2003 | Olhydraulik und Pneumatik2003，47，10： | 1 |
| 12 | A direct mass-ac- tion mechanism explains capacitative calcium entry in Jurkat and skeletal L6 muscle cells显示文摘 | Narayanan B Islam M N Bartelt D | 2003 | Biol Chem2003，278，44： | 1 |
| 13 | Morphological evolution during epitaxial thin film growth:Formation of 2D islands and 3D mounds显示文摘 | Evans J W Tniel P A Bartelt MC | 2006 | Surface Science Reports2006，61，： | 1 |
| 14 | Seasonal occurrence of antibiotics and a beta agonist in an agri-culturally-intensive watershed 显示文摘 | JAIMES - CORREA J C SNOW D D BARTELT - HUNT S L | 2015 | Environmental Pollution2015，205，： | 1 |
| 15 | Ceramic pistons and bushings in hydrostatic axial piston machines-test procedures and results显示文摘 | BARTELT H | 2003 | Olhydraulik und Pneu- matik2003，10，： | 1 |
| 16 | Sorption and permeability of gasoline hydrocarbons in organobentonite porous mcdia显示文摘 | SMITH J A BARTELT S L BURNS S E | 2003 | Jounal of Hazardous Materials2003，96，： | 1 |
| 17 | Immunomodulatory Effectsof Honey Cannot Be Distinguished from Endotoxin显示文摘 | Timm M Bartelt S Hansen E W | 2008 | Cytokine2008，42，1： | 1 |
| 18 | Isolation of bradykinin potentiating peptides from Bothrops jararaca venom 显示文摘 | Ferreira S H Bartelt D C Greene L J | 1970 | Biochemistry1970，9，13： | 1 |
| 19 | Dysphagia following anterior cervical arthrodesis is associated with continuous,strong retraction of the esophagus显示文摘 | MENDOZA LATTES S CLIFFORD K BARTELT R | 2008 | J Bone Joint Surg Am2008，90，2： | 1 |
| 20 | Moist skin care can diminish acute radiation-induced 5 skin toxicity 显示文摘 | Momm F Weissenberger C Bartelt S | 2003 | Strahlenther Onkol2003，179，6： | 1 |
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