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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Double balloon enteroscopy and acute pancreatitis显示文摘Double balloon enteroscopy(DBE)is a new technique, first published and introduced into clinical practice in 2001 by Yamamoto,the inventor of this outstanding method.DBE allows complete visualization,biopsy and treatment of the small bowel.Nowadays,we have some experience of this method for evaluation of the complica- tion rate.Severe complications are described in 1%-1.7% of patients.Acute pancreatitis is a rare complication of the investigation.The incidence of acute pancreatitis after diagnostic DBE is 0.3%in most studies.More than 50 cases of acute pancreatitis have been described in the literature so far.On the contrary,hyperamylasemia after DBE seems to be a rather common condition.Association with acute pancreatitis is supposed to be possible,but not obligatory.The causal mechanism of post-DBE acute pancreatitis is uncertain,and there are several theories in the literature.The most probable cause seems to be a mechanical straining of the endoscope with over-tube on the pancreas or in the papillary area. | Marcela Kopacova Ilja Tacheci Stanislav Rejchrt Jolana Bartova Jan Bures | 2010 | World Journal of Gastroenterology2010，16，19： | 18 |
| 3 | Ultra-high-dose long-acting injectable aripiprazole in chroni refractory schizophrenia:A case report显示文摘 | Lucie Bartova Markus Dold Nicole Praschak-Rieder | 2015 | Clin- ical Toxicology2015，5，5： | 1 |
| 4 | Periodontitis as a risk factor of atherosclerosis 显示文摘 | Bartova J Sommerova P Lyuya-Mi Y | 2014 | J Immunol Res2014，14，3： | 1 |
| 5 | Reproducibility of sonographic measurement of the substantia nigra显示文摘 | Skoloudik D Fandrna T Bartova P | 2007 | Ultrasound Med Biol2007，33，： | 1 |
| 6 | Low virulence of oocysts of Czech Toxoplasma gondii isolates on the basis of biological and genetic characteristics 显示文摘 | Bartova E Sedlak K Literak I | 2003 | J Parasitol2003，89，： | 1 |
| 7 | Nuclear topography and expression of the BCR/ABL fusion gene and its protein level influenced by cell differentiation and RNA interference显示文摘 | BARTOVA E HARNICAROVA A PACHERNIK J | 2005 | Leuk Res2005，29，： | 1 |
| 8 | Discretionary - Accruals Models and Audit Qualifications 显示文摘 | Bartova E F Gulb J Tsui | 2001 | Journal of Accounting and Economics2001，，30： | 1 |
| 9 | COX-2, pl6 and Ki67 expression in DCIS, mieroinvasive and early invasive breast carcinoma with extensive intraductal component 显示文摘 | Bartova M Ondrias F Muy-Kheng T | 2014 | Bratisl Lek Listy2014，115，7： | 1 |
| 10 | Metallic: pigmentation of human teeth and gingiva morphological and immunological aspects 显示文摘 | Venclikova Z Benada O Bartova J | 2007 | Dent Mater J2007，26，1： | 1 |
| 11 | Transeranial sonography in movement disorders显示文摘 | Bartova P Skoloudik D Bar M | 2008 | Biomed Pap Med Fac Univ Palacky Olo- mouc Czech Repub2008，152，： | 1 |
| 12 | Expres- sion of RNA,ZHX-2, and CHC1L genes in multiple myeloma pa- tients and in myeloma cell lines treated with HDAC and Dnmts in- hibitors 显示文摘 | Legartova S Harnicarova-Horakova A Bartova E | 2010 | Neoplasm2010，57，5： | 1 |
| 13 | The influence of the cell cycle, differentiation and irradiation on the nuclear location of the abl, bcr and c-myc genes in human leukemic cells显示文摘 | Bartova E Kozubek S Kozubek M | 2000 | Leuk Res2000，24，： | 1 |
| 14 | Apolipoprotein E gene polymorphisms in relation to chronic periodontitis,periodontopathic bacteria,and lipid levels显示文摘 | Petra Borilova Linhartova Jirina Bartova Hana | 2015 | Archives of Oral Biology2015，60，3： | 1 |
| 15 | Transcranial sonography in movement disorders显示文摘 | Bartova P Skoloudik D Bar M | 2008 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub2008，152，2： | 1 |
| 16 | Apolipoprotein E gene polymorphisms in relation to chronic periodontitis, periodontopathic bacteria, and lipid levels 显示文摘 | Borilova Linhartova P Bartova J Poskerova H | 2014 | Arch Oral Biol2014，60，3： | 1 |
| 17 | Correlation between substantia nigra features detected by sonography and Parkinson disease symptoms显示文摘 | Bartova P Skoloudik D Ressner P | 2010 | J Ultrasound Med2010，29，1： | 1 |
| 18 | Structure and properties of rapidly solidified Al-Cr-Fe-Ti-Si powder alloys 显示文摘 | Bartova B Vojtech D Verner J | 2005 | J Alloys and Compounds2005，387，1： | 1 |
| 19 | Chemical composition and nutritional value of protein concentrates isolated from potato (Solanum tuberosum L, ') fruit juice by precipitation with ethanol or ferric chloride 显示文摘 | Bartova V Barta J | 2009 | Agricultural and Food Chemistry2009，57，19： | 1 |
| 20 | Histone modifications and uclear architecture: a review 显示文摘 | Bartova E Krejci J Harnicarova A | 2008 | J Histochem Cytochem2008，56，8： | 1 |
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