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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | 灿烂弧菌对厚壳贻贝免疫指标和消化酶活性的影响显示文摘为探究灿烂弧菌对厚壳贻贝免疫指标和消化酶活性的影响,用1×10~6、1×10~7、1×10~8个/mL 3个浓度的灿烂弧菌刺激厚壳贻贝,探讨弧菌刺激后厚壳贻贝的一氧化氮合酶(NOS)、一氧化氮(NO)、超氧化物歧化酶(SOD)、丙二醛(MAD)等免疫指标和淀粉酶、蛋白酶等消化酶的变化情况。结果显示,灿烂弧菌刺激48 h后,厚壳贻贝足、鳃、消化腺等组织中仅消化腺的NOS活性较对照组有显著升高,且酶活性随初始细菌浓度的升高而升高,故选用消化腺来测定灿烂弧菌刺激后72 h内的免疫指标和消化酶活性的变化。灿烂弧菌刺激后,48 h内NOS活性较对照组均显著升高。NO含量较对照组均显著升高,与NOS显现相同变化趋势。SOD活性在各浓度灿烂弧菌刺激下较对照组均显著升高,而MAD含量在实验组中含量显著低于对照组。淀粉酶活性在实验组中显著低于对照组,总体呈现先下降后升高的趋势。蛋白酶活性在各实验组中均呈现先升高后下降的趋势。研究表明,灿烂弧菌对厚壳贻贝免疫指标和蛋白酶活性的升高有诱导作用,但对蛋白酶的活性有抑制作用。本研究初步探明了厚壳贻贝对灿烂弧菌的免疫应答机制,为进一步研究灿烂弧菌和厚壳贻贝相互作用机制以及厚壳贻贝免疫机制奠定了基础。 | 梁箫 张亚 刘钰珠 李一峰 BATISTA M F POWER D 杨金龙 | 2018 | 水产学报2018，42，9： | 5 |
| 3 | Preservation of platelet function in patients with cirrhosis and thrombocytopenia undergoing esophageal variceal ligation显示文摘Background:Thrombocytopenia is a possible risk factor for bleeding after band ligation of esophageal varices.However,elevated von Willebrand factor(VWF)in cirrhosis improves platelet function and could decrease this risk.Our objective was to assess platelet function in patients with cirrhosis undergoing esophageal variceal ligation(EVL).Methods:The assessment consisted of platelet count,antigen and activity of VWF and VWF-cleaving protease ADAMTS-13 activity,and a platelet adhesion and aggregation test simulating vascular flow in vivo(Impact-RR)prior to EVL.Results:Totally 111 patients were divided into three groups according to platelet count:(1)<50×109/L(n=38,34.2%);(2)50×109/L to 100×109/L(n=47,42.3%);and(3)>100×109/L(n=26,23.4%).No statistically significant difference was found in the aggregate size of platelets[group 1:41.0(31.8–67.3)μm 2;group 2:47.0(33.8–71.3)μm 2;and group 3:47.0(34.0–66.0)μm 2;P=0.60]and no significant correlation was found between aggregate size and platelet count(Spearman r=0.07;P=0.47).Surface coverage was 4.1%(2.8%–6.7%),8.5%(4.0%–10.0%),and 9.0%(7.1%–12.0%)(P<0.001)in groups 1,2 and 3,respectively and correlated with platelet count(Spearman r=0.39;P<0.0001).There was no significant difference between groups in VWF or ADAMTS-13.Post-EVL bleeding occurred in six(5.4%)patients(n=2 in group 1,n=1 in group 2,and n=3 in group 3;P=0.32).Patients with bleeding had higher MELD scores[15.0(11.3–20.3)versus 12.0(10.0–15.0);P=0.025],but no difference was demonstrated for platelet function parameters.Conclusion:Platelet function is preserved even in the presence of thrombocytopenia,including in the patients with post-EVL bleeding. | Evandro de Oliveira Souza Elbio Antonio D’Amico Tania Rubia Flores da Rocha Caroline Marcondes Ferreira Juliana Medeiros Batista Luiz Augusto CarneiroD’Albuquerque Flair Jose Carrilho Alberto Queiroz Farias | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，6： | 3 |
| 4 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 5 | Deep subsurface electronic defect image contrast and resolution amplification in Si wafers using infrared photo carrier radiometry 显示文摘 | BATISTA J MANDELIS A SHAUGHNESSY D | 2004 | Applied Physics Letters2004，85，10： | 1 |
| 6 | Microcystin-LR Causes the Collapse of Actin Filaments in Primary Human Hepatocytes显示文摘 | Batista T Sousa G D Suput S | 2003 | Aquatic Toxicology2003，65，： | 1 |
| 7 | Infraredphotocarrier radiometry of semiconductors: Physicalprinciples, quantitative depth profilometry, and scanningimaging of deep subsurface electronic defects显示文摘 | MANDELIS A BATISTA J SHAUGHNESSY D | 2003 | Phys RevB2003，67，20： | 1 |
| 8 | Generalized Jordan-Wigner Trans- formations 显示文摘 | Batista C D Ortiz G | 2001 | Phys Rev Lett2001，81，6： | 1 |
| 9 | Anti-inflammatory effect of physical training in heartfailure:role of TNF-alpha and IL-10显示文摘 | BATISTA M L Jr LOPES R D SEELAENDER M C | 2010 | Cardiol2010，95，2： | 1 |
| 10 | Risk factors for catheter-related bloodstream infection:a prospective multicenter study in Brazilian intensive care units显示文摘 | Bicudo D Batista R Furtado GH | | 0，，04： | 1 |
| 11 | Risk factors for catheter- related bloodstream infection: a prospective multicenter study in Brazilian intensive care units 显示文摘 | Bicudo D Batista R Furtado GH | 2011 | Braz J Infect Dis2011，15，4： | 1 |
| 12 | Is it possible to compare researchers with different scientific interests 显示文摘 | BATISTA P D CAMPITELI M G KINOUCHI O | 2006 | Scientometrics2006，68，1： | 1 |
| 13 | Biodesulfurization: a mini review about the immediate search for the future technology显示文摘 | Boniek D Figueiredo D Batista dos Santos AF | 2015 | Clean Technologies and Environmental Policy2015，17，1： | 1 |
| 14 | Analysis of in vitro and in vivo anti oxi-dant properties of hydrophilic fractions from theseaweed halimeda monile 显示文摘 | Batista Gonzalez A E Silva A M D 0 E Vidal-NovoaA | 2012 | Journal of Food Bio-chemistry2012，36，2： | 1 |
| 15 | Gastric antiulcer activity of Syngonanthus arthrotrichus SILVEIRA 显示文摘 | Batista L M de Almeida ABA Magri L D | 2004 | Biol Pharm Bull2004，27，3： | 1 |
| 16 | Lidar observations of atmospheric sodium at an equatorial location显示文摘 | Clemesha B R Simonich D M Batista P P | 1998 | Journal of Atmospheric and Solar-Terrestrial Physics1998，60，： | 1 |
| 17 | Densification behavior, microstructure evolution, and wear performance ofselective laser melting processed commercially pure titanium 显示文摘 | GU D D HAGEDOMRN Y C MEINERS W MENG G B BATISTA R J S WISSENBACH K POPRAWE R | 2012 | Acta Materialia2012，60，9： | 1 |
| 18 | Identification of genotype 3 hepatitis E virus (HEV) in serum and fecal samples from pigs in Thailand and Mexico, where genotype 1 and 2 HEV strains are prevalent in the respective human populations显示文摘 | Cooper K Huang F F Batista L Rayo C D Bezanilla J C Toth T E Meng X J | 2005 | J Clinic Microbiol2005，43，4： | 1 |
| 19 | Is it possible to compare researchers with different scientific interests? 显示文摘 | BATISTA P D CAMPITELI M G KINOUCHI O | 2006 | Scientometrics2006，68，1： | 1 |
| 20 | Risk factors {or cath- eter-related bloodstream infection: a prospective multieenter study in Brazilian intensive care units显示文摘 | Bicudo D Batista R Furtado GH | 2011 | Brazilian Journal of Infectious Diseases2011，15，4： | 1 |
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