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| 1 | Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME显示文摘AIM To counteract/reveal celecoxib-induced toxicity and NO system involvement. METHODS Celecoxib(1 g/kg b.w. ip) was combined with therapy with stable gastric pentadecapeptide BPC 157(known to inhibit these lesions, 10 μg/kg, 10 ng/kg, or 1 ng/kg ip) and L-arginine(100 mg/kg ip), as well as NOS blockade [N(G)-nitro-L-arginine methyl ester(L-NAME)](5 mg/kg ip) given alone and/or combined immediately after celecoxib. Gastrointestinal, liver, and brain lesions and liver enzyme serum values in rats were assessed at 24 h and 48 h thereafter. RESULTS This high-dose celecoxib administration, as a result of NO system dysfunction, led to gastric, liver, and brain lesions and increased liver enzyme serum values. The L-NAME-induced aggravation of the lesions was notable for gastric lesions, while in liver and brain lesions the beneficial effect of L-arginine was blunted. L-arginine counteracted gastric, liver and brain lesions. These findings support the NO system mechanism(s), both NO system agonization(L-arginine) and NO system antagonization(L-NAME), that on the whole are behind all of these COX phenomena. An even more complete antagonization was identified with BPC 157(at both 24 h and 48 h). A beneficial effect was evident on all the increasingly negative effects of celecoxib and L-NAME application and in all the BPC 157 groups(L-arginine + BPC 157; L-NAME + BPC 157; L-NAME + L-arginine + BPC 157). Thus, these findings demonstrated that BPC 157 may equally counteract both COX-2 inhibition(counteracting the noxious effects of celecoxib on all lesions) and additional NOS blockade(equally counteracting the noxious effects of celecoxib + L-NAME). CONCLUSION BPC 157 and L-arginine alleviate gastrointestinal, liver and brain lesions, redressing NSAIDs' post-surgery application and NO system involvement. | Domagoj Drmic Danijela Kolenc Spomenko Ilic Lara Bauk Marko Sever Anita Zenko Sever Kresimir Luetic Jelena Suran Sven Seiwerth Predrag Sikiric | 2017 | World Journal of Gastroenterology2017，23，29： | 2 |
| 2 | The role of smart home in smart real estate显示文摘 | Erfaneh Allameh Mohammadali Heidari Jozam Bauke de Vries Harry Timmermans Jakob Beetz Farhang Mozaffar | 2012 | Journal of European Real Estate Research2012，5，2： | 1 |
| 3 | Molecular and structural aspecial of fimbriae biosynthesis and assembly in Escherichia coli 显示文摘 | Olaf M Bauke O | 1999 | FEMS Microbiol Rev1999，19，： | 1 |
| 4 | Three-dimensional structures of enzymes useful for β -lactam antibiotic production显示文摘 | Thomas R B Hiromi Y Bauke W D | 2004 | Curr Opin Biotech2004，15，4： | 1 |
| 5 | Is basic research providing answers if adjuvant anti-estrogen treatment of breast cancer can induce cognitive impairment?显示文摘 | Bauke Buwalda Sanne B Schagen | 2013 | Life Sci2013，93，17： | 1 |
| 6 | A cognitive interpretation of organizational complexity 显示文摘 | GUIDO FIORET'FI BAUKE VISSER | 2004 | E: CO Special Double Issue2004，，6： | 1 |
| 7 | Molecular and structural aspects of fimbriae biosynthesis and assembly in Escherichia coli 显示文摘 | Olaf M Bauke O | 1999 | FEMS Microbiology Reviews1999，19，： | 1 |
| 8 | Bacterial Lipases显示文摘 | Jaeger K Ransac S Bauke W | 1994 | FEMS Microbiology Reviews1994，15，1： | 1 |
| 9 | Bacterial lipases显示文摘 | Jaeger Karl-Erich Ransac Stéphane Dijkstra Bauke W | 1994 | Microbiology Reviews1994，15，1： | 1 |
| 10 | Parameter Estimation for Power-Law Tail Distributions by Maximum Likelihood Methods显示文摘 | | 2007 | European Physical Journal B2007，44，5： | 1 |
| 11 | α/β Hydrolase fold enzymes:the family keeps growing显示文摘 | Nardini Marco Dijkstra Bauke W | 1999 | Current Opinion in Structural Biology1999，9，6： | 1 |
| 12 | Titanium as the material of choice for cementless femoral components in total hip arthroplasty 显示文摘 | HEADWC BAUK D J EMERSON R H | 1995 | Clin Orthop1995，311，： | 1 |
| 13 | Quaternion lorentz transformation显示文摘 | ALAM M S BAUK S | 2011 | Physics Essays2011，24，2： | 1 |
| 14 | Titanium as the material of choice for cementless femoral components in total hip arthroplasty显示文摘 | HEAD W C BAUK D J EMERSON R H | 1995 | Clinical Orthopaedics and Related Research1995，311，： | 1 |
| 15 | Evaluation in multi - actor policy processes: accountability, learning and co - operation 显示文摘 | Frans -bauke Var Der Meer Jurian Edelenbos | 2006 | Evaluation2006，12，2： | 1 |
| 16 | Molecular and structural aspecial of fimbriae biosynthesis and assembly in Escherichia coli 显示文摘 | OLAF M BAUKE O | 1999 | FEMS Microbiol Rev1999，19，1： | 1 |
| 17 | Zur Kenntniss der sexuellen Generation bei den Gattungen Platycerium, Lygodium und Gymnogramme 显示文摘 | Bauke H | | Bot Zeit 1878 36:753 - 7600，，： | 1 |
| 18 | Aus dem botanischen Nachlasse von Bauke 显示文摘 | Bauke H | | Beilage zur Bot Zeit0，3816，： | 1 |
| 19 | Randomized, double-blind, plaeebo-controlled sludy of supplemenlal oral L-arginine in patients with heart failure 显示文摘 | Rector TS Bauk A J Muller KA el al | 1996 | Circulation1996，93，： | 1 |
| 20 | Way finding during fire evacuation; an analysis of unannounced fire drills in a hotel at night显示文摘 | Margrethe Kobes Ira Helsloot Bauke de Vries | 2010 | Building and Environment2010，45，3： | 1 |
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