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| 1 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 2 | Improved identification of viable myocardium using second harmonic imaging duing dobutamine stress echocardiography显示文摘 | Sozzi F B Poldermabs D Bax J J | 2001 | Heart2001，86，6： | 1 |
| 3 | Microbicides-evaluating multiple ormulations of C31G显示文摘 | Douville K McCormick D | 2002 | Contraception2002，66，5： | 1 |
| 4 | Relationship between preoperative viability and postoperative improvement in LVEF and heart failure symptoms显示文摘 | Bax J J Visser FC Poldermans D | 2001 | J Nucl Med2001，42，1： | 1 |
| 5 | 18 F-fluorodeoxyglucose imaging with positron emission tomography and single photon emission computed tomography: cardiac applications显示文摘 | Bax JJ Patton JA Poldermans D | 2000 | Semin Nucl Med2000，30，4： | 1 |
| 6 | Clinical assessment of myocardial hibernation显示文摘 | Schinkel AFL Bax JJ Poldermans D | 2005 | Heart2005，91，1： | 1 |
| 7 | The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery显示文摘 | Poldermans D Boersma E Bax JJ | 1999 | N Engl J Med1999，341，： | 1 |
| 8 | Laparoseopy in Infants and Children:A Prosprective Study on Feasibility and the Impact on Routine Surgery显示文摘 | Ure B M Bax N M Van der Zee D C | 2000 | J Pediatr Surg2000，35，： | 1 |
| 9 | Improved identification of viable myocardium using second harmonic imaging duing dobutamine stress echocardiography显示文摘 | Poldermans D Bax J J | 2001 | Heart2001，86，： | 1 |
| 10 | Long-term prognostic value of dobutamine-atropine stress echocardiography in 1737 patients with known or suspected coronary artery disease: a single-center experience显示文摘 | Poldermans D Fioretti PM Boersma E Bax | 1999 | Circulation1999，99，6： | 1 |
| 11 | Dobutamne stress echocardiography and technetiμm-99m-tetrofosmin/fluorine 18-fluo-rodeoxyglucose single-photon emission computed tomography and influence of resting ejection fraction to assess myocardial viability in patients with severe left ventricular dysfunction and healed myocardial infarction显示文摘 | Rambaldi R Poldermans D Bax JJ | 1999 | Am J Cardiol1999，84，2： | 1 |
| 12 | Relationship between preoperative viability and postoperative improvement in LVEF and heart failure symptoms显示文摘 | Bax JJ Visser FC Poldermans D | 2001 | J Nucl Med2001，42，1： | 1 |
| 13 | Cell pattern- ing via linker-free protein functionalization of an or- ganic conducting polymer (polypyrrole) electrode显示文摘 | Bax D V Tipa R S Kondyurin A | 2012 | Acta Biomaterialia2012，8，7： | 1 |
| 14 | Pre dictors of cardiac events after major vascular surgery: Role of clinical characteristics, dobutamine echocardiography,and beta-blocker therapy 显示文摘 | Boersma E Poldermans D Bax JJ | 2001 | JAMA2001，285，14： | 1 |
| 15 | Simplification of1H NMR spectra by selective excitation of experimental subspectra显示文摘 | Davis D G Bax A | 1985 | Journal of the American Chemical Society1985，107，24： | 1 |
| 16 | Evaluation of left ventrieular function and volumes in patients with ischaemic cardiomyopathy: gated single-photon emission computed tomography versus two-dimensional echccardiography 显示文摘 | Vourvouri E C Poldermans D Bax J J | 2001 | EurJ Nud Med2001，28，11： | 1 |
| 17 | Statins are associated with a reduced incidence of perioperative mortality in patients undergoing major non cardiac vascular surgery显示文摘 | Poldermans D Bax JJ Kertai MD | 2003 | Circulation2003，107，： | 1 |
| 18 | Should major vascular surgery be delayed because of preoperative cardiac testing in intermedi- ate - risk patients receiving beta - blocker therapy with tight heart rate control? 显示文摘 | Poldermans D Bax JJ Schouten O | 2006 | J Am Coil Cardiol2006，48，5： | 1 |
| 19 | Identifying hotspots for biodiversity management using rank abundance distributions显示文摘 | DUNSTAN P K BAX N J FOSTER S D | 2012 | Diversity and Distributions2012，18，1： | 1 |
| 20 | Guidelines for pre-operative cardiac risk assessment and perioperative cardiac mana-gement in non - cardiac surgery: the task force for preoperativecardiac risk assessment and perioperative cardiac management innon-cardiac surgery of the European Society of Cardiology (ESC)and endorsed by the European Society of Anaesthesiology (ESA)显示文摘 | Poldermans D Bax JJ Boersma E | 2010 | Eur J Anaesthesiol2010，27，： | 1 |
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