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| 1 | Impact of alcohol on hepatitis C virus replication and interferon signaling显示文摘Hepatitis C virus (HCV) is one of the main etiological factors responsible for liver disease worldwide. It has been estimated that there are over 170 million people infected with HCV worldwide. Of these infected individuals, approximately 75% will go on to develop a life long necroinflammatory liver disease, which over decades, can result in serious complications, such as cirrhosis and hepatocellular carcinoma. Currently there is no effective vaccine and whilst antiviral therapies have been improved, they are still only effective in approximately 50% of individuals. HCV infection stands as a major cause of global morbidity and suffering, and places a signifi cant burden on health systems. The second highest cause of liver disease in the western world is alcoholic liver disease. Frequently, HCV infected individuals consume alcohol, and the combined effect of HCV and alcohol consumption is deleterious for both liver disease and response to treatment. This review discusses the impact of alcohol metabolism on HCV replication and the negative impact on interferon (IFN)-α treatment, with a particular focus on how alcohol and HCV act synergistically to increase oxidative stress, ultimately leading to exacerbated liver disease and a reduction in the effi cacy of IFN-α treatment. A better understanding of the complicated mechanisms at play in hepatocytes infected with HCV and metabo- lizing alcohol will hopefully provide better treatment options for chronic hepatitis C individuals that consume alcohol. | Erin M McCartney Michael R Beard | 2010 | World Journal of Gastroenterology2010，16，11： | 5 |
| 2 | Identification of gene-selective modulators of the bile acid receptor FXR显示文摘 | Dussault I Beard R Lin M | 2003 | J Biol Chem2003，278，9： | 1 |
| 3 | Subsidy free pricing of interruptible service contracts 显示文摘 | BEARD T R SWEENEY H GROPPER D M | 1995 | Energy Economics1995，17，1： | 1 |
| 4 | Information consensus in mul- tivehicle cooperative control: Collective group behavior through lo- cal interaction 显示文摘 | WRen R W Beard E M Atkins | 2007 | IEEE Control Systems Magazine2007，27，2： | 1 |
| 5 | Information consensus in multivehicle cooperative control 显示文摘 | REN W BEARD R W ATKINS E M | 2007 | IEEE Control Systems Maga- zine2007，27，2： | 1 |
| 6 | Iron isotope fractionation by Fe(Ⅱ) oxidizing photoautotrophic bacteria 显示文摘 | Croal L R Johnson C M Beard B L | 2004 | Geochimica et Cosmochimica Acta2004，68，： | 1 |
| 7 | Identification of gene-selective modulators of the bile acid receptor FXR显示文摘 | Dussault I Beard R Lin M | 2003 | J Biol Chem2003，278，9： | 1 |
| 8 | Multiple exciton generation in colloidal silicon nanocrystals显示文摘 | Beard M C Knutsen K P Yu P R | 2007 | Nano Letters2007，7，8： | 1 |
| 9 | Multiple UAV coalitions for a search and prosecute mission显示文摘 | Joel G M Sujit P B Beard R W | | 0，，62： | 1 |
| 10 | Coordinated target assignment and intercept for unmanned air vehicles显示文摘 | BEARD R W MCLAIN T W GOODRICH M | 2002 | IEEE Transactions on Robotics and Automation2002，8，6： | 1 |
| 11 | Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice显示文摘 | Tropea D Giacometti E Wilson NR Beard C McCurry C Fu D D Flannery R Jaenisch R Sur M | | 0，，： | 1 |
| 12 | Coordinated target assignment and intercept for unmanned air vehicles显示文摘 | Beard R W McLain T W Godrich M A | 2002 | IEEE Transactions on Robotics and Automation2002，18，6： | 1 |
| 13 | Reproductive and endocrine function in rams exposed to the organoehlorine pesticides lindane and pentachlorophenol from coneeption显示文摘 | Beard A P Bartlewski P M Chandolia R K | 1999 | Reprod Fertil1999，115，2： | 1 |
| 14 | Coordinated Target Assignment and Intercept for Unmanned Air Vehicles显示文摘 | Beard R W McLain T W Goodrich M | | 0，，06： | 1 |
| 15 | Information consensus in mul-tivehicle cooperative control 显示文摘 | Ren W Beard R W Atkins E M | 2007 | IEEE Control Systems Maga-zine2007，27，2： | 1 |
| 16 | Molecular and epidemiologic trends of caliciviruses associated with outbreak of acute gastroenteritis in the United States ( 2000 -2004 ) 显示文摘 | BLANTON L H ADAMS S M BEARD R S | 2006 | J infect Dis2006，193，3： | 1 |
| 17 | Coordinated Target Assignment and Intercept for Unmanned Air Vehicles 显示文摘 | Beard R W McLain T W Goodrich M A | 2002 | IEEE Transaction on Robotics and Automation2002，18，6： | 1 |
| 18 | Coordinated target assignment and intercept for unmanned air vehicles 显示文摘 | Beard R W Mclain T W Goodrish M | 2002 | IEEE Transactions on Robotics and Automation2002，18，3： | 1 |
| 19 | A stable and efficient transformation system for Butyrivibrio fibrisolvens OB 156显示文摘 | Beard C E Hefford M A Forster R J | 1995 | Curr Microbiol1995，30，： | 1 |
| 20 | Highly efficient multiple exciton generation in colloidal PbSe and PbS quantum dots显示文摘 | Ellingson R J Beard M C Johnson J C | 2005 | Nano Lett2005，5，： | 1 |
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