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| 1 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 2 | Current role of palliative interventions in advanced pancreatic cancer显示文摘Pancreatic adenocarcinoma is the third leading cause of cancer death in the United States. Unfortunately, at diagnosis, most patients are not candidates for curative resection. Surgical palliation, a procedure performed with the intention of relieving symptoms or improving quality of life, comes to the forefront of management. This article reviews the palliative management of unresectable pancreatic cancer, including obstructive jaundice, duodenal obstruction and pain control with celiac plexus block. Although surgical bypasses for both biliary and duodenal obstructions usually achieve good technical success, they result in considerable perioperative morbidity and mortality, even when performed laparoscopically. The effectiveness of selfexpanding metal stents for biliary drainage is excellent with low morbidity. Surgical gastrojejunostomy for duodenal obstruction appears to be best for patients with a life expectancy of greater than 2 mo while endoscopic stenting has been shown to be feasible with good symptom relief in those with a shorter life expectancy. Regardless of the palliative procedure performed, all physicians involved must be adequately trained in end of life management to ensure the best possible care for patients. | Chelsey C Ciambella Rachel E Beard Thomas J Miner | 2018 | World Journal of Gastrointestinal Surgery2018，10，7： | 4 |
| 3 | Thermodynamic constraints for biochemical networks 显示文摘 | Beard D A Babson E Curtis E | 2004 | J Theor Biol2004，228，3： | 1 |
| 4 | High-level expression and purification of untagged and histidine-tagged HIV-1 reverse transcriptase显示文摘 | Hou E W Prasad R Beard W A | 2004 | Protein Exp Purif2004，34，1： | 1 |
| 5 | A sustainable solution for dietary iron deficiency through plant biotechnology and breeding to increase seed ferritin control显示文摘 | Theil E C Burton J W Beard J L | 1997 | European Journal of Clinical Nutrition1997，51，4： | 1 |
| 6 | Information consensus in mul- tivehicle cooperative control: Collective group behavior through lo- cal interaction 显示文摘 | WRen R W Beard E M Atkins | 2007 | IEEE Control Systems Magazine2007，27，2： | 1 |
| 7 | Screen for novel cry genes by hybridization显示文摘 | Beard C E Ranasinghe C A Khurst R J | 2001 | Lett Appl Microbiol2001，33，： | 1 |
| 8 | PbTe colloidal nanocrystals: Synthesis, characterization, and multiple exciton generation显示文摘 | Murphy J E Beard M C Norman A G | 2006 | Journal of the American Chemical Society2006，128，10： | 1 |
| 9 | Information consensus in multivehicle cooperative control 显示文摘 | REN W BEARD R W ATKINS E M | 2007 | IEEE Control Systems Maga- zine2007，27，2： | 1 |
| 10 | Simultaneous inversion of airborne electro- magnetic date for resistivity and magnetic permeability 显示文摘 | Beard L P Nyquist J E | 1998 | Geo- physics1998，63，5： | 1 |
| 11 | Airborne vertical magnetic gradient for near-surface applications显示文摘 | Doll W E Gamey T J Beard L P | 2006 | The Leading Edge2006，1，： | 1 |
| 12 | Incidence and clinical features of trigeminal neuralgia, Rochester, Minnesota, 1945 - 1984 显示文摘 | Katusic S Beard CM Bergstralh E | 1990 | Ann Neurol1990，27，1： | 1 |
| 13 | Airborne vertical magnetic gradient for near-surface applications显示文摘 | Doll W E Gamey T J Beard L P | 2006 | The Leading Edge2006，25，1： | 1 |
| 14 | Geographical distribution of a chromosome7C and 17 intergenomic translocation in cultivated oat 显示文摘 | Jellen E N Beard J L | 2000 | CropSci2000，40，25： | 1 |
| 15 | Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice显示文摘 | Tropea D Giacometti E Wilson NR Beard C McCurry C Fu D D Flannery R Jaenisch R Sur M | | 0，，： | 1 |
| 16 | Geographical distribution of a chromosome 7C and 17 intergenomic translocation显示文摘 | Jellen E N Beard J | 2000 | Crop Science2000，40，： | 1 |
| 17 | Effect of resistant starch type Ⅲ polymorphs on human colon microbiota and short chain fatty acids in human gut model显示文摘 | Lesmes U Beards E J Gibson G R | | 0，，： | 1 |
| 18 | Prevalence and characteristics of e- cigarette users in Great Britain: Findings from a general population survey of smokers 显示文摘 | Brown J West R Beard E | 2014 | Addictive Behaviors2014，39，6： | 1 |
| 19 | Childhood motor skill proficiency as a predictor of adolescent physical activity显示文摘 | Barnett LM van Beurden E Morgan PJ Brooks LO Beard JR | 2009 | J Adolesc Health2009，，3： | 1 |
| 20 | Geographical distribution of a chromosome 7Cand 17intergenomic translocation显示文摘 | Jellen E N Beard J | 2000 | Crop Science2000，40，： | 1 |
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