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| 1 | Gut hormones, and short bowel syndrome: The enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptation显示文摘Short bowel syndrome (SBS) refers to the malabsorption of nutrients, water, and essential vitamins as a result of disease or surgical removal of parts of the small intestine. The most common reasons for removing part of the small intestine are due to surgical intervention for the treatment of either Crohn's disease or necrotizing enterocolitis. Intestinal adaptation following resection may take weeks to months to be achieved, thus nutritional support requires a variety of therapeutic measures, which include parenterai nutrition. Improper nutrition management can leave the SBS patient malnourished and/or dehydrated, which can be life threatening. The development of therapeutic strategies that reduce both the complications and medical costs associated with SBS/long-term parenterai nutrition while enhancing the intestinal adaptive response would be valuable. Currently, therapeutic options available for the treatment of SBS are limited. There are many potential stimulators of intestinal adaptation including peptide hormones, growth factors, and neuronally-derived components. Glucagon-like peptide-2 (GLP-2) is one potential treatment for gastrointestinal disorders associated with insufficient mucosal function. A significant body of evidence demonstrates that GLP-2 is a trophic hormone that plays an important role in controlling intestinal adaptation. Recent data from clinical trials demonstrate that GLP-2 is safe, well-tolerated, and promotes intestinal growth in SBS patients. However, the mechanism of action and the localization of the glucagon-like peptide-2 receptor (GLP-2R) remains an enigma. This review summarizes the role of a number of mucosal-derived factors that might be involved with intestinal adaptation processes; however, this discussion primarily examines the physiology, mechanism of action, and utility of GLP-2 in the regulation of intestinal mucosal growth. | GR Martin PL Beck DL Sigalet | 2006 | World Journal of Gastroenterology2006，12，26： | 3 |
| 2 | Diabetes and fractures:an overshadowed association显示文摘 | Khazai NB Beck GR Jr Umpierrez GE | 2009 | Curr Opin Endocrinol Diabetes Obes2009，16，43： | 1 |
| 3 | The effects of thiazolidinediones on human bone marrow stromal cell differentiation in vitro and in thiazolidinedione-treated pa- tients with type 2 diabetes 显示文摘 | Beck Jr GR Khazai NB Bouloux GF | 2013 | Transl Res2013，161，3： | 1 |
| 4 | The effects of thiazolidinediones on human bone marrow stromal cell differentiation in vitro and in thiazolidinedione-treated patients with type 2 diabetes显示文摘 | Beck GR Jr Khazai NB Bouloux GF | 2013 | Transl Res2013，161，3： | 1 |
| 5 | Phosphate is a specific signal for induction of osteopontin gene expression显示文摘 | Beck GR Jr Zerler B Moran E | 2000 | Proc Natl Acad Sci USA2000，97，15： | 1 |
| 6 | Phosphate is a specific signal for induction of osteopontin gene expression显示文摘 | Beck GR Jr Zerler B Moran E | 2000 | Proc Natl Acad Sci U S A2000，97，15： | 1 |
| 7 | Diabetes and fractures:an overshadowed association显示文摘 | Khazai NB Beck GR Jr Umpierrez GE | | 0，，06： | 1 |
| 8 | Comparison of intubation following propofol and alfentanil with intubation following thiopentone and suxamethonium显示文摘 | Beck GN Masterson GR Richards J | 1993 | Anaesth1993，48，： | 1 |
| 9 | Diabetes and fractures: an overshadowed association 显示文摘 | Khazai NB Beck GR Jr Umpierrez GE | 2009 | Curr Opin Endocrinol Diabetes Obes2009，16，6： | 1 |
| 10 | Infection of human pe-ripheralblood mononuclear cells by erythrocyte-bound HIV-1:effects of antibodiesand complement显示文摘 | Beck Z Brown BK Matyas GR ef al | 2011 | Virology2011，412，： | 1 |
| 11 | Bioactive silica-based nanoparticles stimulate bone-forming osteoblasts,suppress boneresorbing osteoclasts,and enhance bone mineral density in vivo显示文摘 | Beck GR Jr Ha SW Camalier CE | 2012 | Nanomedicine2012，8，6： | 1 |
| 12 | Bioactive silica-based nanoparticles stimulate bone-forming osteoblasts,suppress bone-resorbing osteoclasts, and enhance bonemineral density in vivo 显示文摘 | Beck GR Jr Ha SW Camalier CE | 2012 | Nanomedicine2012，8，6： | 1 |
| 13 | Relationship between alkaline phosphatase levels, osteopontin expression, and mineralization in difirentiating MC3T3-EI osteoblasts 显示文摘 | Beck GR Jr Sullivan EC Moran E | 1998 | J Cell Biochem1998，68，2： | 1 |
| 14 | Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation显示文摘 | Flowers S Nagl NG Jr Beck GR Jr | 2009 | J Biol Chem2009，284，10： | 1 |
| 15 | Bioactive silica-based nanoparticles stimulate bone-forming osteoblasts, suppress bone-re- sorbing osteoclasts, and enhance bone mineral density in vivo显示文摘 | Beck GR Jr Ha SW Camalier CE | 2012 | Nanomedicine2012，8，6： | 1 |
| 16 | The effects of thiazolidinediones on human bone marrow stomal cell differ- entiation in vitro an in thiazolidinedione-treated patients with type 2 diabetes 显示文摘 | Beck GR Jr Khazai NB Bouloux GF | 2013 | Transl Res2013，161，： | 1 |
| 17 | Diabetes and fractures:an overshadowed association显示文摘 | Khazai N B Beck GR Jr Umpierrez GE | 2009 | Curr Opin Endocrinol Diabetes Obes2009，16，6： | 1 |
| 18 | Diabetes and fractures: an overshadowed association显示文摘 | Khazai NB Beck GR Jr Umpierrez GE | 2009 | Curr Opin En-docrinol Diabetes Obes2009，16，6： | 1 |
| 19 | Infection of human periph- eralblood mononuclear cells by erythrocyte-bound HIV-1 :effects of anti-bodiesand complement显示文摘 | Beck Z Brown BK Matyas GR | 2011 | Virology2011，412，： | 1 |
| 20 | Infection of human peripheral blood mononuelear cells by erythrocyte-bound HIV-1: effects of antibodies and complement显示文摘 | Beck Z Brown BK Matyas GR | 2011 | Virology2011，412，2： | 1 |
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