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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Optical properties of the metals Al, Co, Cu, Au, Fe, Pb, Ni, Pd, Pt, Ag, Ti, and W in the infrared and far infrared 显示文摘 | Ordal M A Long L L Bell R J | 1983 | Applied Optics1983，22，7： | 2 |
| 3 | Diuretics:1,2,4-Benzothiadiazine-1,1-Dioxides显示文摘 | NoveUo F C Bell S C Abram s E L A | 1960 | J Org Chem1960，25，6： | 1 |
| 4 | The interaction of two parallel non-coplanar identical surface cracks under tension and bending显示文摘 | Moussa W A Bell R Tan C L | 1999 | International Journal of Pressure Vessels and Piping1999，79，3： | 1 |
| 5 | Autooxidation of oil emulsions during the Artemia enrichment process显示文摘 | Mcevoy L A Navarro J C Bell J G | 1995 | Aquaculture1995，134，12： | 1 |
| 6 | Fractures and dislocations of the spine complicating ankylosing spondylitis:a report of six cases显示文摘 | Grisolia A Bell R L Peltier L F | 2004 | Clin Orthop Relat Res2004，，422： | 1 |
| 7 | 显示文摘 | Ordal M A Long L L Bell R J | 1983 | Appl Opt1983，22，7： | 1 |
| 8 | Optimising lipid ntrition in first - feeding flatfish larvae 显示文摘 | J G Bell L A Mcevoy Esterez A | 2003 | Aq- uaculture2003，，227： | 1 |
| 9 | Sulfide shapecontrol in high strength alloy steels显示文摘 | Luyckx L Bell J R Mclean A | 1970 | Met Trans1970，1，11： | 1 |
| 10 | CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status显示文摘 | Kinter A L Hennessey M Bell A | 2004 | Journal of Experimental Medicine2004，200，3： | 1 |
| 11 | Development and application of molecular marker linkage maps in woody fruit crops显示文摘 | N F Weeden M Hemmatt D M Lawson M Lodhi R L Bell A G Manganaris B I Reischs S K Brown G N Ye | 1994 | Euphytica1994，77，12： | 1 |
| 12 | Optical properties of the metals Al,Co,Cu,Au,Fe,Pb,Ni,Pd,Pt,Ag,Ti and W in the infrared and far infrared显示文摘 | M A Ordal L L Long R J Bell | | 0，，： | 1 |
| 13 | The phase II urokinase-streptokinase pulmonary embolism trial: a national cooperative study显示文摘 | Sasahra A A Bell W R Simon T L Stengle J M Sherry S | 1975 | Thromb Diath Haemorrh1975，33，： | 1 |
| 14 | Sampling errors for satel?lite-derived tropical rainfall:Monte Carlo study using a space-time stochastic model显示文摘 | BELL T L ABDULLAH A MARTIN R L | 1990 | Journal of Geophysical Research1990，95，： | 1 |
| 15 | Air temperature and winter mortality: implications for the persistence of the invasive mussel, Perna viridis in the intertidal zone of the south- eastern United States显示文摘 | Firth L B Knights A M Bell S S | 2011 | J Experim Mar Biol Ecol2011，400，25： | 1 |
| 16 | Optical properties of the metals AI,Co,Cu,Au,Fe,Pb,Ni,Pd,Pt,Ag,Ti,and W in the infrared and far infrared显示文摘 | ORDAL M A LONG L L BELL R J | 1983 | App Opt1983，22，2： | 1 |
| 17 | CD25(+)CD4(+) regulatory T cells from the perip-heral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and associated with favorable clinical markers of disease status显示文摘 | Kinter A L Hennessey M Bell A | 2004 | J Exp Med2004，200，： | 1 |
| 18 | Fast electron transport in laser-produced plasmas and the KALOS code for solution of the Vlasov Fokker Planck equation显示文摘 | Bell A R Robinson A P L Sherlock M | 2006 | Plasma Phys Control Fusion2006，48，： | 1 |
| 19 | Sulfide shape control in high strength alloy steels显示文摘 | Luyckx L Bell J R Mclean A | 1970 | Met Trans1970，1，11： | 1 |
| 20 | XPD codon 751 polymorphism,metabolism genes,smoking,and bladder cancer risk显示文摘 | STERN M C JOHNSON L R BELL D A | 2002 | Cancer Epidemiol Biomarkers Prev2002，11，101： | 1 |
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